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A Permissioned Blockchain-based System for Collaborative Drug Discovery

Research and development of novel molecular compounds in the pharmaceutical industry can be highly costly. Lack of confidentiality can prevent a product from being patented or commercialized. As an effect, cross-organizational collaboration is virtually non-existent. In this paper, we introduce a blockchain-based solution to the collaborative drug discovery problem so that participants can maintai

A Decentralized Dynamic PKI based on Blockchain

The central role of the certificate authority (CA) in traditional public key infrastructure (PKI) makes it fragile and prone to compromises and operational failures. Maintaining CAs and revocation lists is demanding especially in loosely-connected and large systems. Log-based PKIs have been proposed as a remedy but they do not solve the problem effectively. We provide a general model and a solutio

Contextualizing agency in new path development : how system selectivity shapes regional reconfiguration capacity

This paper examines factors shaping the reconfiguration capacity of regional innovation systems (RISs). ‘System selectivity’ is introduced as a concept to understand how factors such as regional imaginaries, power relations and directionality shape how RIS reconfiguration plays out. A comparative case study illustrates the conceptual arguments, investigating industrial change in two Swedish region

Using ecological context to interpret spatiotemporal variation in natural selection

Spatiotemporal variation in natural selection is expected, but difficult to estimate. Pollinator-mediated selection on floral traits provides a good system for understanding and linking variation in selection to differences in ecological context. We studied pollinator-mediated selection in five populations of Dalechampia scandens (Euphorbiaceae) in Costa Rica and Mexico. Using a nonlinear path-ana

Increased Frequencies of Switched Memory B Cells and Plasmablasts in Peripheral Blood from Patients with ANCA-Associated Vasculitis

B cells are thought to play a central role in the pathogenesis of antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV). ANCAs have been proposed to cause vasculitis by activating primed neutrophils to damage small blood vessels. We studied a cohort of AAV patients of which a majority were in remission and diagnosed with granulomatosis with polyangiitis (GPA). Using flow cytomet

Associations between perfluoroalkyl substances and thyroid hormones after high exposure through drinking water

BACKGROUND: The reported associations for several per- and polyfluoroalkyl substance (PFAS) with thyroid hormones are inconsistent in epidemiological studies. The purpose of the current study was to investigate the possible association of thyroid hormones in relation to serum levels of perfluorohexane sulfonate, perfluorooctane sulfonate and perfluorooctanoic acid, in a Swedish general population,

Painted copies and views on authenticity in seventeenth-century Sweden

The research on forgeries, fakes, copies, replicas, facsimiles, substitutions, appropriations and imitations in pre-modern times is now a growing field of research in art history, and as shown the difference between these concepts is anything but clear (Heisterberg, Müller-Bechtel & Putzger eds. 2018; Cupperi ed. 2014; Wood 2008). The aim of this paper is to look at the artistic production of

In the Presence of Great Men : The German National Portrait Gallery 1913-1933

In his “Dialogue about the Art of Portraiture” (1906), Viennese Art Historian Julius von Schlosser made the following critical observation of the behaviour of visitors in art museums:They [the public] are not interested in the portrait as an expression or disclosure of an artistic personality, but rather the actual human being, one can say, looming behind it, who is known to them in a very particu

Early 20th-Century Curatorial Strategies to Enhance the Power of Portraiture : Ludwig Justi and the National Portrait Gallery in Berlin 1913-1933

The emergence of the national portrait gallery as a museum phenomenon during the nineteenth century reflects a broader interest in portraiture at the time. The first of its kind was the National Portrait Gallery in London. Pivotal to the foundation of the gallery in 1856 was historian Thomas Carlyle’s declaration that a portrait had put him in contact with the past. In 1913, a German National Port

SARS-CoV-2 Spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity

There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo. Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS. Microscale thermopho

Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence

Deregulated expression of the MYC oncogene is a frequent event during tumorigenesis and generally correlates with aggressive disease and poor prognosis. While MYC is a potent inducer of apoptosis, it often suppresses cellular senescence, which together with apoptosis is an important barrier against tumor development. For this latter function, MYC is dependent on cyclin-dependent kinase 2 (CDK2). H

Collaboration and guidelines for the coordination of health care for frail older persons with intellectual disability : A national survey of nurses working in municipal care

Aims: To describe and compare perceptions of collaboration between care providers on the part of three groups of Registered Nurses working in municipal care and having particular responsibility concerning the care of frail older people with intellectual disability (ID); and, furthermore, to investigate the presence of and compliance with guidelines for the coordination of care.Design: National surAims: To describe and compare perceptions of collaboration between care providers on the part of three groups of Registered Nurses working in municipal care and having particular responsibility concerning the care of frail older people with intellectual disability (ID); and, furthermore, to investigate the presence of and compliance with guidelines for the coordination of care. Design: National su

Analysis of clinical knowledge, absenteeism and availability of resources for maternal and child health : a cross-sectional quality of care study in 10 African countries

OBJECTIVE: Assess the quality of healthcare across African countries based on health providers' clinical knowledge, their clinic attendance and drug availability, with a focus on seven conditions accounting for a large share of child and maternal mortality in sub-Saharan Africa: malaria, tuberculosis, diarrhoea, pneumonia, diabetes, neonatal asphyxia and postpartum haemorrhage.METHODS: With nation