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Dysfunctional mucociliary clearance in asthma and airway remodeling – New insights into an old topic

Bronchial asthma is a heterogeneous respiratory condition characterized by chronic airway inflammation, airway hyperresponsiveness and airway structural changes (known as remodeling). The clinical symptoms can be evoked by (non)specific triggers, and their intensity varies over time. In the past, treatment was mainly focusing on symptoms’ alleviation; in contrast modern treatment strategies target

Simulating surface soil moisture on sandy beaches

A model that simulates surface moisture content on sandy beaches for aeolian transport applications is developed and integrated into the aeolian transport model AeoLiS. The moisture content of a thin surface layer (≈2 mm thickness) is computed as a function of wave runup, precipitation, evaporation, percolation, and capillary rise from the groundwater table. The groundwater table is simulated usin

Electrophysiological evidence for a Whorfian double dissociation of categorical perception across two languages

Languages vary considerably in how they group objects into categories. For example, the word taza in Spanish can refer to either cup or mug in English, whereas glass can refer to either copa or vaso – two different types of glasses –, in Spanish. It is still debated whether such language distinctions cause differences in early perceptual processing between speakers of different languages. Here, fo

Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure– a national cohort study

Background: We aimed to evaluate cumulative occurrence and impact of COVID-19 in patients with chronic respiratory failure (CRF) treated with long-term oxygen therapy (LTOT). Material and methods: Data were obtained from the SCIFI-PEARL study on the entire Swedish population and on patients with oxygen-dependent CRF and no COVID-19 diagnosis before start of LTOT. Analyses were performed for three

Binocular vision and foraging in ducks, geese and swans (Anatidae)

Wide variation in visual field configuration across avian species is hypothesized to be driven primarily by foraging ecology and predator detection. While some studies of selected taxa have identified relationships between foraging ecology and binocular field characteristics in particular species, few have accounted for the relevance of shared ancestry. We conducted a large-scale, comparative anal

Age of acquisition in second language thinking

Debates around age effects in L2 learning have mostly centred around the domains of phonology, morphosyntax, and lexis. In this chapter, we expand the scope to conceptual and cognitive restructuring, much in line with Long’s (1990, 2013) discussion of the limits of age effects. Drawing on an extensive review of the extant literature, the current chapter examines the role that age of L2 acquisition

The man in the purple coat : Art and empire in Ilia Repin’s Reception of Volost Elders

This chapter discusses Ilia Repin’s court commission, Reception of Volost Elders by Alexander III in the Courtyard of the Petrovsky Palace in Moscow (1886). It argues that the painting reflected marginalizing discourses on the non-Russian minorities dominant at the outset of Alexander III’s rule. Repin employed a differentiating approach to rendering ethnically and religiously diverse representati

Embodying transnational shared space : Pirjo Honkasalo’s The 3 Rooms of Melancholia

The article investigates the ways in which Pirjo Honkasalo’s documentary The 3 Rooms of Melancholia (2004), examining the impact of the Russian-Chechen war on children, engenders a transnational audience through cinematic qualities, and most importantly through embodiment, producing a strongly affective resonance in the spectator. I argue that through a strategically affective approach to transnat

Egypt Ignited : How Steam Power Arrived on the Nile and Integrated Egypt into Industrial Capitalism (1820s-76)

Hur nådde fossildriven teknik Egypten på sin väg mot global dominans? Denna avhandling presenterar en socioekologisk historia av energiteknologier i förkoloniala Egyptens jordbruksproduktion (1820-talet-76). Den placerar dem i 1800-talet, början på Kapitalocenens epok; och i Egyptens fall är detta samtidigt en del av Storbritanniens fossila imperiums uppkomst. Denna avhandling behandlar hur ångmasHow did fossil-fuelled technology find its way to Egypt on its way to global dominance? This thesis presents a socioecological history of energy technologies in agrarian production in pre-colonial Egypt (1820s – 76). It situates them in the nineteenth century, understood as the beginning of the epoch of the Capitalocene; and in Egypt’s case, this is simultaneously part of the rise of Britain’s fos

Development and first results of a magnetic sample environment for polarized neutron imaging of thin metal sheets

Polarized neutron imaging brings the great advantage of analyzing bulk magnetic properties with good spatial resolution. The technique is based on the interaction of the neutron spin with magnetic samples or free magnetic fields and observing the changes to a spin-polarized neutron beam. The high sensitivity to even small magnetic fields is a benefit in obtaining magnetization information but simu

Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity

Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L

Instituting: Space-making, refusal and organising in the arts and beyond

This edited collection proposes instituting as a potentially critical methodology in curating, art making and social organizing today, and seeks to discuss forms and structures that take place inside and outside institutions. Rethinking of collective artistic and social practices through and beyond the “waves of institutional critique” this books discusses instituting as a process in continuous cr

Excitonic Dynamics at the Type-II Polytype Interface of InP Platelets

Indirect excitons are the focus of intense research due to the opportunity of studying degenerate quantum gases and liquids in an excitonic system. To realize such systems, it is highly advantageous to have as little scattering as possible. A polytype type-II interface is formed between wurtzite and zincblende InP due to the band alignment. Electrons gather on the zincblende and holes on the wurtz

Bottom-up approaches to microLEDs emitting red, green and blue light based on GaN nanowires and relaxed InGaN platelets

Miniaturization of light-emitting diodes (LEDs) with sizes down to a few micrometers has become a hot topic in both academia and industry due to their attractive applications on self-emissive displays for high-definition televisions, augmented/mixed realities and head-up displays, and also on optogenetics, high-speed light communication, etc. The conventional top-down technology uses dry etching t

7 Life Science Companies’Engagement with their University-basedEntrepreneurship Ecosystem: A Multi-Layered Approach

This chapter focuses on life science companies’ engagement with their university- based entrepreneurship ecosystem. It analyzes multiple case studies with life science companies based around Lund University in Sweden. Our results demonstrate that life science companies engage with their ecosystem through three interconnected engagement logics: network, relations, and governance. We propose a model