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Background & aims: Alcohol consumption has been inversely associated with type 2 diabetes (T2D), but its influence on autoimmune diabetes is unclear. We investigated the risk of latent autoimmune diabetes in adults (LADA) and T2D in relation to alcohol intake and assessed if potential associations were modified by genetic susceptibility to diabetes. Methods: We used data from a case–control st

Upper-limb complications (ULCs) in diabetes, affecting joints, tendons, muscles, con-nective tissue, nerves, and skin, are underrecognized but prevalent conditions in type 1 and type 2 diabetes. Advances in diabetes care have extended life expectancy, leading to an aging population with diabetes with increased susceptibility to long-term complications beyond traditional vascular issues. Despite so

För att samhällets gröna omställning ska fortgå behövs det fortfarande ett bra alternativ till råolja. Ett hållbart alternativ som undersöks är bioolja. Bioolja framställs till skillnad från råolja med biomassa som råmaterial. För att bränsle med bra kvalitet ska tillverkas av detta så måste biomassan uppgraderas i flera steg i bioraffinaderier. Ett av dessa steg innehåller en katalytisk hydrodeoxThe phasing out of fossil fuels continues to be of great importance if our society is to complete the green transition. One of the most interesting alternatives to fossil fuels is bio-fuels but these have not been shown to outperform fossil fuels in all areas, as of yet. This is especially true in applications that require high performance and have high safety standars, such as the aviation indust

new species, Begonia arunachalensis D.Borah & Wahlsteen (Begoniaceae) is described and illustrated. It is distributed in Papum Pare District of Arunachal Pradesh where it grows near streams in rock crevices. Begonia arunachalensis is similar to B. brevicaulis A.DC. but differs in its pendent fruits, number of locules and capsule wings, and longer lateral wings. It belongs to Begonia sect. Dipl

Rotational structures in 249Md have been observed for the first time. One set of states forms a pair of strongly coupled bands with relatively strong E2 transitions and no identifiable M1 transitions between the two signature partners. Another set of states suggests a decoupled sequence of E2 transitions. These bands are assigned as based on the 7/2−⁢[514] and on the favored signature of the 1/2−⁢

The medical profession plays a crucial role in tackling the health impacts of climate change and in promoting a green transition of society and the health sector. Despite this, opportunities for action are still quite unknown within the profession, and no mandatory education is required in interns' or residents' education. Medical schools, on the contrary, both in Sweden (due to legislation) and a

CSF concentrations of β-amyloid 42 (Aβ42) and phosphorylated tau (p-tau) are well-established biomarkers of Alzheimer's disease and have been studied in relation to several neuropathological features both in patients and in cognitively unimpaired individuals. The CSF p-tau/Aβ42 ratio, a biomarker combining information from both pathophysiological processes, has emerged as a promising tool for moni

Improved understanding of the mechanisms driving heterotrophic CO2 emissions after rewetting of a dry soil may improve projections of future soil carbon fate. While drying and rewetting (DRW) under laboratory conditions have demonstrated that heterotrophic CO2 emissions depend on DRW features and soil and environmental conditions, these laboratory insights have not been validated in field conditio

Direct reprogramming of somatic cells into induced neurons (iNs) has become an attractive strategy for the generation of patient-specific neurons for disease modeling and regenerative neuroscience. To this end, adult human dermal fibroblasts (hDFs) present one of the most relevant cell sources. However, iNs generated from adult hDFs using two-dimensional cultures are difficult to maintain in vitro

In an interconnected world, climate change impacts can cascade across sectors and regions, creating systemic risks. Here we analyse cascading climate change impacts on the EU, originating from outside the region, and identify critical intervention points for adaptation. Using network analysis, we integrate stakeholder-co-produced impact chains with quantitative data for 102 countries across foreig

The AU Microscopii planetary system is only 24 Myr old, and its geometry may provide clues about the early dynamical history of planetary systems. Here, we present the first measurement of the Rossiter–McLaughlin effect for the warm sub-Neptune AU Mic c, using two transits observed simultaneously with the European Southern Observatory’s (ESO’s) Very Large Telescope (VLT)/Echelle SPectrograph for R

Introduction Asthma may increase the risk of comorbidities and systemic inflammation, but population data are scarce. This study aimed to compare comorbidities and systemic inflammation between those with and without current asthma and to identify characteristics linked to comorbidities and biomarkers. Methods In a cross-sectional analysis of 28 828 people aged 50–64 in the Swedish CArdioPulmonary

Remission is emerging as a feasible treatment goal in moderate-to-severe asthma, driven by the success of biologic therapies in controlling inflammation and reducing exacerbations. Yet current definitions of remission—focused on symptom control, lung function, and corticosteroid reduction—lack precision, can only be ascertained retrospectively, and do not reflect the underlying mechanisms and path

Climate change is already impacting our environment and health, with rising sea levels, extreme weather, and higher temperatures. Greenhouse gas levels are at their highest in three million years, making climate-related health risks increasingly urgent. Heatwaves, wildfires, and floods lead to mortality, trauma, and non-communicable diseases both in the short and long term. Climate change also alt

Scholarship in the last decades has increasingly paid attention to the rhetoric of race and peoplehood in early Christian literature. It has been shown how the construction of Christian identity took place through ethnic reasoning, with writers using metaphors of parenthood, kinship, homeland and descent to express what it meant to be a Christian. These studies have typically focused on pre-Consta

Background: Dihydrotestosterone (DHT), the most potent ligand to the androgen receptor, is synthesised from testosterone (T) by 5α-reductase type 1 and 2. While type 1 is expressed in several non-reproductive tissues in both sexes, men also express high levels of the high-affinity type 2 isoform in reproductive tissues; yet women have a higher circulating DHT to T (DHT/T) ratio than men. We hypoth

whiE is a complex locus that specifies the polyketide spore pigment in Streptomyces coelicolor A3(2). Two divergently oriented promoters, whiEP1 and whiEP2, were identified in the whiE gene cluster, and their activities were analyzed during colony development in wild-type and sporulation-deficient strains. Both promoters were developmentally regulated; whiEP1 and whiEP2 transcripts were detected t

This dissertation focuses on Aceh Chinese’s lived experiences in Aceh, an Indonesian province marked by repeated violence and major social changes. These include the 1965–1966 anti-communist mass killings, the protracted conflict between the Free Aceh Movement (GAM) and the Indonesian state, the devastation of the 2004 tsunami, and the implementation of Shariʿa law. It addresses how the community

This paper reports the first measurement of the transverse momentum (pT) spectra of primary charged pions, kaons, (anti)protons, and unidentified particles as a function of the charged-particle flattenicity in pp collisions at s=13 TeV. Flattenicity is a novel event shape observable that is measured in the pseudorapidity intervals covered by the V0 detector, 2.8

Research on cephalopod early ontogeny has significantly advanced in recent decades, including embryo organogenesis and neurogenesis and early behavioural adaptations, particularly in commercially important and coastal species. Within this context, here we compiled current knowledge on the collection, handling and care under experimental conditions and monitoring in the field of cephalopod eggs and