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Early Postreperfusion Proteomics Reveal Divergent Inflammatory Responses in Kidney Transplantation with Implications on Outcomes

BACKGROUND: Ischemia/reperfusion injury is an unavoidable consequence of kidney transplantation, yet the characteristics of the immediate immune response after reperfusion and its impact on transplant outcomes remain poorly characterized in the clinical setting.METHODS: We conducted a cohort study including 63 kidney transplant recipients (26 living-donor, 37 deceased-donor) with an extended 4-y f

The Potential of Dosimetry and the Visualization of Microbeam Arrays in NIPAM Gel at the PETRA III Synchrotron

Spatially fractionated radiotherapy (SFRT) is emerging as a powerful tool in cancer therapy for patients who are ineligible for treatment with clinically established irradiation techniques. Microbeam radiotherapy (MRT) is characterized by spatial dose fractionation in the micrometre range. This presents challenges in both treatment planning and dosimetry. While a dosimetry system with a spatial re

Desensitization with antigen-specific immunoadsorption interferes with complement in ABO-incompatible kidney transplantation

BACKGROUND: Complement activation was characterized during and after desensitization treatment in 19 consecutive patients receiving ABO-incompatible (ABOi) living donor kidney transplants to assess the effect of desensitization protocol including antigen-specific immunoadsorption (IA) on complement activation.METHODS: All patients received rituximab- and tacrolimus-based triple treatment. Anti-A/B

Efficacy and safety of continuous local infusion of ropivacaine after retroperitoneoscopic live donor nephrectomy

Morphine-based analgesia is effective but can compromise donor safety. We investigated whether continuous infusion of local anesthetics (CILA) can provide sufficient pain control and reduce morbidity related to opiate analgesics after hand-assisted retroperitoneoscopic (HARS) live donor nephrectomy. Forty consecutive live kidney donors underwent HARS and were treated with the ON-Q system providing

The AGORA High-Resolution Galaxy Simulations Comparison Project VII. Satellite quenching in zoom-in simulation of a Milky Way-mass halo

Context. Satellite galaxies experience multiple physical processes when interacting with their host halos, often leading to the quenching of star formation. In the Local Group, satellite quenching has been shown to be highly efficient, affecting nearly all satellites except the most massive ones. While recent surveys study Milky Way-analogs to assess how representative our Local Group is, the domi

How stellar mass and disc size shape the formation and migration of super-Earths

The occurrence rate of close-in super-Earths is higher around M-dwarfs compared to stars of higher masses. In this work, we aim to understand how the super-Earth population is affected by the stellar mass, the size of the protoplanetary disc, and viscous heating. We utilised a standard protoplanetary disc model with both irradiated and viscous heating, together with a pebble accretion model, to si

Decentralized glomerular filtration rate (GFR) estimates in healthy kidney donors show poor correlation and demonstrate the need for improvement in quality and standardization of GFR measurements in Sweden

OBJECTIVE: Glomerular filtration rate (GFR) is generally accepted as the best overall index of renal function. Thus, all potential live kidney donors are tested to ensure that they have a normal GFR before they are eligible for kidney transplantation. The choice of GFR test is very much dependent on local traditions and may include iohexol, 51Cr-EDTA, inulin, or creatinine clearance based on urine

Binary stars in the Milky Way nuclear stellar cluster

Context. Intermediate mass galaxies, including the Milky Way, typically host both a supermassive black hole (SMBH) and a nuclear stellar cluster (NSC). Binary systems residing in an NSC evolve dynamically via frequent close encounters with surrounding stars and secular processes related to the SMBH. Aims. Although the evolution of very soft and very hard binaries can be predicted semi-analytically

Initial experience with hypothermic machine perfusion of kidneys from deceased donors in the Uppsala region in Sweden

BACKGROUND: Simple cold storage (CS) is the gold standard for organ preservation. Recently, evidence has been presented suggesting compared with CS hypothermic machine perfusion (HMP) improves the quality and outcome of kidneys for transplantation. Uppsala has used the LifePort Kidney Transporter to preserve deceased donor kidneys. We evaluated our first single-center 52 cases retrospectively.METH

Introducing hand-assisted retroperitoneoscopic live donor nephrectomy : learning curves and development based on 413 consecutive cases in four centers

BACKGROUND: Hand-assisted and retroperitoneoscopic techniques reduce the risk of bleeding and intraabdominal complications in living donor nephrectomy (LDN). This study reports on our four-center experience, development, and learning curves from the first 413 LDNs using a hand-assisted retroperitoneoscopic (HARS) technique.METHODS: The first 413 consecutive donors operated on using HARS were inclu

Factors influencing outcome of simultaneous kidney and pancreas transplantation : a 23-year single-center clinical experience

INTRODUCTION: Simultaneous kidney and pancreas transplantation (SKPT) has become an effective treatment for patients who have diabetes mellitus type I with advanced nephropathy. This study assesses the progress of the SKPT program at Uppsala University Hospital, Sweden, and evaluates prognostic factors for graft survival.MATERIALS AND METHODS: Between February 1986 and September 2009, we performed

Liver regeneration is impaired by FK778 in partially hepatectomized rats, while supplemental uridine restores both liver growth and hepatocyte proliferation

AIM: The impact of mandatory immunosuppression on liver regeneration after segmental liver transplantation is of clinical importance. FK778, a novel immunosuppressant, inhibits pyrimidine biosynthesis and prevents rejection after organ transplantation in a dose-dependent manner. We investigated the effect of FK778 at a highly effective dose on liver regeneration in a small animal model.METHODS: In

Hepatic venous outflow reconstruction in right live donor liver transplantation

The increasing experience with live donor liver transplantation has allowed for the identification of potential morbidities associated with technical considerations. Technical graft failure can be associated with both inflow and outflow vascular compromise. Although the latter has not always been given the relevance of the former, evidence pointing to its pivotal role continues to mount. We believ

Tropical Cyclones Across Global Basins : Dynamics, Tracking Algorithms, Forecasting, and Emerging Scientometric Research Trends

Tropical cyclones (TCs) pose significant threats to life and property across global ocean basins, and forecasting their structural evolution, track, and intensity remains a major scientific challenge. This review synthesizes the current understanding of TCs across major basins, that is, the Pacific, Atlantic, and North Indian Oceans, with a focus on the key environmental factors influencing TC beh

Persistence of the ecological niche in pond damselflies underlies a stable adaptive zone despite varying selection

Following the development of regression-based methods to estimate natural and sexual selection, evolutionary biologists have quantified the strength, mode, and direction of selection in natural populations. Although this approach has been successful, its limitations include the lack of replication across species, which compromises the generality of the inferences beyond microevolutionary time scal

Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial

Background: Direct oral anticoagulants (DOACs) reduce the rate of thromboembolism in patients with atrial fibrillation but the benefits and risks in survivors of intracerebral haemorrhage are uncertain. We aimed to determine whether DOACs reduce the risk of ischaemic stroke without substantially increasing the risk of recurrent intracerebral haemorrhage. Methods: PRESTIGE-AF is a multicentre, open

Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain

Tensor-valued encoding in diffusion MRI allows probing of microscopic anisotropy in tissue, however, time-dependent diffusion (TDD) can bias results unless b-tensors are carefully tuned to account for TDD. We propose two novel strategies for tuning b-tensors to enable accurate measurements without interference from TDD due to restricted diffusion. The first strategy involves identifying encoding t