INTRODUCTION: Drugs directed toward the epidermal growth factor receptor (EGFR), such as erlotinib (Tarceva®) and gefitinib (Iressa®), are used for the treatment of patients with advanced non-small cell lung cancer (NSCLC), including patients with brain metastases. However, whether erlotinib actually enters into brain metastases has not been adequately elucidated. In this study, we investigated th

Situations of multilingualism and language contact in which language varieties are small in scale and relatively equal in social status are important phenomena affecting processes of language change throughout human history. Despite this, our knowledge about the outcomes of multilingualism and language contact in this kind of setting remains limited. The current thesis provides insight into the li

Most pathogens can infect a number of different host species, but host species often differ considerably in susceptibility to a given pathogen. In the case of zoonotic pathogens, natural hosts typically present little or no disease symptoms, while humans and other “spill-over” hosts often present severe symptoms. Differences in susceptibility do not only occur between natural and non-natural hosts

Ovid closed his 15-book epic of transformation with the metamorphosis of the poet into his work and his work into its own reception, summed up in the final word: uiuam (‘I shall live’). The prophecy has been self-fulfilling, in that the Metamorphoses has entertained readers and inspired artists in different media for two millennia since the poet’s death in AD 17. Loved for its vast repository of m

BackgroundLittle is known about health and wellbeing among patients with nephrotic syndrome (NS), despite it being a serious condition in patients with renal failure. In order to promote health, it is important that both healthcare professionals and patients are aware of the signs and symptoms of the disease.ObjectivesThe aim was to explore patients’ experience of suffering from nephrotic syndrome

AIMS: The present study sought to determine predictors for success and outcomes of patients who underwent cardiac implantable electronic devices (CIED) extraction indicated for systemic or local CIED related infection in particular where complete lead removal could not be achieved.METHODS AND RESULTS: ESC-EORP ELECTRa (European Lead Extraction ConTRolled Registry) is a European prospective lead ex

Med Bolognareformen 2007 blev i princip all högre utbildning i Sverige, som omfattas av Högskoleförordningens examensordning, målstyrd på basis av ett särskilt sätt att relatera olika kunskapsformer till varandra, vilka kommer till uttryck i både Blooms taxonomi och den s.k. SOLO-taxonomin (= structure of the observed learning outcome). Sedan 2007 delas därför lärandemålen i examensordning, studie

The chapter provides an overview of membrane applications in conventional and lignocellulosic biorefineries. Driven by the trend towards “white biotechnology” the market and applications for membrane processes in biorefineries are growing rapidly since membrane processes have been identified as energy-efficient and highly selective separation processes in the different stages of biorefining. The a

Aims/hypothesis: Rapid and adequate islet revascularisation and restoration of the islet–extracellular matrix (ECM) interaction are significant factors influencing islet survival and function of the transplanted islets in individuals with type 1 diabetes. Because the ECM encapsulating the islets is degraded during islet isolation, understanding the process of revascularisation and engraftment afte

Tissue transglutaminase (tTG) and microbial transglutaminase (mTG) cross-link gliadins to form complexes that expose immunogenic neo-epitopes to produce tTG and mTG-neo-epitope antibodies. The aim of this study was to test the diagnostic performance of antibodies against non-complexed and complexed forms of transglutaminases, to correlate their activities to the intestinal damage and to explore ag

Rationale, Aims, and Objectives: Primary health care often has overall responsibility for elderly patients and their medication treatment. This is a challenging task due to the issue of multiple caregivers, different systems for documentation and multimorbidity among the elderly. The multiprofessional project SÄKLÄK2 was developed to raise drug safety in Swedish primary health care, and this study