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Exposure-response relationships between movements and postures of the wrist and carpal tunnel syndrome among male and female house painters : a retrospective cohort study

OBJECTIVES: To investigate exposure-response relationships between measured movements and postures of the wrist and the incidence of carpal tunnel syndrome (CTS), and any modifications by sex.METHODS: In 2011, we established a historical cohort of 9364 members of the Painters' Union in Denmark. Self-reported task distributions were obtained by questionnaire (53% responded) and combined with sex-sp

Consistency in long-distance bird migration: Contrasting patterns in time and space for two raptors

As the evolutionary responses to environmental change depend on selection acting on individual differences,disentangling within- and between-individual variation becomes imperative. In animalmigration research, multiyear tracks are thus needed to estimate the individual consistency of phenotypictraits. Avian telemetry studies have recently provided the first evidence of individuality acrossspace a

CYP1A2 - a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients

BACKGROUND: Endocrine resistance is a major obstacle to optimal treatment effect in breast cancer. Some genetic markers have been proposed to predict response to aromatase inhibitors (AIs) but the data is insufficient. The aim of the study was to find new genetic treatment predictive markers of AIs.METHODS: The ongoing population-based BC-blood study in Lund, Sweden includes women with primary bre

The rate of joint replacement in osteoarthritis depends on the patient's socioeconomic status : a cohort study of 71,380 patients

Background and purpose - Assessment of potential disparities in access to care is a vital part of achieving equity in health and healthcare. We have therefore studied the effect of socioeconomic status (SES) on the rates of knee and hip replacement due to osteoarthritis. Methods - This was a cohort study in Skåne, Sweden. We included all residents aged ≥ 35 years with consultations between 2004 an

Vestibular asymmetry increases double support time variability in a counter-balanced study on elderly fallers

Vestibular asymmetry is a common cause of dizziness in the elderly, for whom it precipitates the risk of falling. Previous studies have shown that those with vestibular asymmetry displayed an altered variability in double support time (DST) compared to controls. However, swing time (SwT) variability findings are conflicting. In this study, we investigated if vestibular asymmetry might be causally

Judicial Interpretation and Indigenous Peoples’ Rights to Lands, Participation and Consultation. The Inter-American Court of Human Rights’ Approach

This article proposes a critical legal analysis of the jurisprudence of the Inter-American Court of Human Rights regarding indigenous peoples’ rights to lands, participation, and consultation. It focuses on the role that cultural diversity as a legal standard has played in the recognition of the indigenous peoples’ right to consultation and participation in all matters that directly affect them, a

Outline of a Non-Deliberative, Mood-Based, Theory of Action

In a series of famous experiments, Benjamin Libet claimed to have shown that there is no scientific basis for our commonsensical understanding of freedom of the will. The actions we are about to undertake register in our brains before they register in our conscious minds. And yet, all that Libet may have shown is that long-invoked notions such as “the will” and “freedom” are poor explanations of h

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors, aged 26-74 years. Aging associates with increa

Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells

The canonical Wnt signaling can be silenced either through β-catenin-mediated ubiquitination and degradation or through phosphorylation of Tcf and Lef by nemo-like kinase (NLK). In the present study, we generated NLK deficient animals and found that these mice become cyanotic shortly before death because of lung maturation defects. NLK-/- lungs exhibited smaller and compressed alveoli and the mese

Street art and visual ecocriticism

This paper explores the meaning and potential impact of a number of street artworks that in different ways address and problematise how human beings relate to the biotic community – that is to say a community founded on biocentrism that includes as its members “soils, waters, plants, and animals, or collectively: the land” (Leopold, 1949/1968, p. 203.).The paper argues that while, for example, inf

QRS broadening due to terminal distortion is associated with the size of myocardial injury in experimental myocardial infarction

INTRODUCTION: Not only repolarization, but also depolarization ECG indexes reflect the progression of ischemic injury. The aim was to assess the QRS duration and morphology dynamics during the prolonged coronary occlusion and their association with the myocardial area at risk (MaR) and final infarct size (IS).METHODS: In pigs, myocardial infarction was induced by inflation of an angioplasty balloo

Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin

Huntington's Disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. The YAC128 mouse model of HD expresses the full-length human huntingtin protein with 128 CAG repeats and replicates the phenotype and neurodegeneration that occur in HD. Several studies have implicated a role for neuroinflammation in HD pathogenesis. Studies on presymp

Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?

PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of pre

Understanding the WiFi usage of university students

In this work, we analyze the use of a WiFi network deployed in a large-scale technical university. To this extent, we leverage three weeks of WiFi traffic data logs and characterize the spatio-temporal correlation of the traffic at different granularities (each individual access point, groups of access points, entire network). The spatial correlation of traffic across nearby access points is also

A toolbox to evaluate non-residential lighting and daylighting retrofit in practice

In the field of lighting and daylighting, standard monitoring procedures to assess the overall performance of retrofit projects are scarce. Nevertheless, access to monitored data is crucial in assessing whether daylighting or electric lighting systems deliver the expected performance in terms of cost-effectiveness, energy efficiency and lighting quality. In order to bridge this gap, a lighting ret

A systematic review of studies in the contributions of the work environment to ischaemic heart disease development

BACKGROUND: There is need for an updated systematic review of associations between occupational exposures and ischaemic heart disease (IHD), using the GRADE system.METHODS: Inclusion criteria: (i) publication in English in peer-reviewed journal between 1985 and 2014, (ii) quantified relationship between occupational exposure (psychosocial, organizational, physical and other ergonomic job factors)