Glucagon-like peptide 1 (GLP-1) augments glucose-stimulated insulin secretion (GSIS) through cAMP-induced activation of protein kinase A (PKA), and stimulates beta-cell proliferation and reduces beta-cell apoptosis in rodent islets. This study explored islet GSIS, PKA expression, and markers of apoptosis (caspase 3/7 activity) and proliferation (PKBalpha and pancreatic and duodenal homeobox gene 1

This thesis explores the external debt situation of developing countries and donor responses in terms of aid composition and debt relief. Primarily, these issues are important for future debt sustainability and therefore for creating beneficial conditions for accelerating growth and reducing poverty. With a focus on domestic factors (e.g. regime type) and exogenous shocks (e.g. terms of trade vol

A convolutional code can be used to detect or correct infinite sequences of errors or to correct infinite sequences of erasures. First, erasure correction is shown to be related to error detection, as well as error detection to error correction. Next, the active burst distance is exploited, and various bounds on erasure correction, error detection, and error correction are obtained for convolution

Regular column on performing arts in the weekly newspaper Arbetaren (The Worker).

In atrial fibrillation (AF), the body surface signal pattern varies considerably from one patient to another as well as over time. We have developed a new method for ECG-based characterization of AF which explores the morphology of the f-waves. Following QRST cancellation, the method divides the atrial signal into short blocks and performs a model-based analysis of each block. The blocks are then

The climate conditions inside nuclear reactor containments depend on several parameters e.g. different moisture and heat sources; the containment design; material properties etc. Knowledge about the climatic condition is an important area to e.g. maintain a proper condition for mechanical and electrical equipment; minimize the corrosion risks of reinforcement and metallic components; prevent vapor

Popular Abstract in Swedish Nästan 35% av den totala avrinningen i Gula floden härstammar från dess källområde och vattenförsörjningen nedströms är därför beroende av de rådande förhållandena i detta område. Minskad vattenföring i floden på grund av klimatförändringar förväntas leda till negativa konsekvenser för de 110 miljoner invånarna i avrinningsområdet och problem uppstår för såväl jordbrukeThe source region of the Yellow River contributes about 35% of the total water yield in the Yellow River basin playing an important role for meeting the downstream water resources requirements. The declining water availability caused by climate change in the source region of the Yellow River is expected to have severe repercussions for the 110 million basin inhabitants in terms of water resources

Popular Abstract in Swedish Våglängden för röntgenstrålning är mycket kortare än den för synligt ljus. I själva verket är den jämförbar med avståndet mellan atomer i fasta material, vilket är i storleksordningen en tiondels nanometer. Genom att använda ljus med så kort våglängd är det möjligt att studera materials struktur på atomär nivå. Spridning av röntgenstrålar har utvecklats till ett ovärderThe wavelength of x-ray radiation is much shorter than that of visible light. In fact, it is comparable to the distances between atoms in solids, which is on the order of one tenth of a nanometer. Using light of such a short wavelength, it is possible to study the structure of materials on the atom level. Scattering of x-rays has been developed into an invaluable tool to analyze various characteri

Efficacy of reperfusion therapy can be assessed as myocardial salvage index (MSI) by determining the size of myocardium at risk (MaR) and myocardial infarction (MI), (MSI = 1-MI/MaR). Cardiovascular magnetic resonance (CMR) can be used to assess MI by late gadolinium enhancement (LGE) and MaR by either T2-weighted imaging or contrast enhanced SSFP (CE-SSFP). Automatic segmentation algorithms have

Translocation-associated gene fusions are well recognized in acute myeloid leukemia. Other molecular genetic changes are less well known. The novel cDNA technology has opened the avenue to large-scale gene expression analysis. Our aim was to perform cDNA microarray analysis of acute myeloid leukemia (AML).

IgA1 mesangial deposition is the hallmark of IgA nephropathy and Henoch-Schönlein purpura, the onset of which often follows infections. Deposited IgA has been reported as polymeric, J chain associated, and often, hypogalactosylated but with no information concerning the influence of the IgA repertoire or the link between immune stimuli and IgA structure. We explored these issues in the α1KI mouse