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Ethanol reduces rCBF activation of left dorsolateral prefrontal cortex during a verbal fluency task

Measurements of regional cerebral blood flow were made in 20 healthy young male subjects during sobriety and inebriation (0.06 % blood alcohol) during rest and during performance of a word fluency test. Word production was decreased during inebriation. The activation within the frontotemporal part of the left dorsolateral prefrontal cortex was preserved during intoxication. During inebriation no a

Adopting a child with cleft lip and palate: A study of parents' experiences.

Abstract Adoption of Chinese children with cleft lip and palate (CLP) has become increasingly more common in Sweden. The aim of this study was to examine parents' experience when adopting a child with CLP. Since 2008, 34 adopted children with CLP have been treated in our department. A questionnaire was sent to 33 of the families and 30 of them answered (91%). The parents had queued from 1 month to

Clinical trial design in haemophilia.

Summary: Progress in the evidence-based care of haemophilia A and B worldwide has been historically challenged by the dearth of evaluable outcome data, including but not limited to the safety and effectiveness of therapeutic interventions. These challenges are partially rooted in the inherent difficulty of conducting prospective clinical trials and observational studies with statistically meaningf

Sustainable consumption and resource management in the light of life cycle thinking

Approaches to address unsustainable ways of societal development constantly proliferate, but total consumption of resources and aggregate environmental impacts continue rising. This could partially be explained by weak attempts to develop comprehensive sustainability strategies that address the entire life cycle of products and especially resource extraction and use phases. This paper seeks to exp

Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region.

Previous Icelandic studies reported that single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) region and the 5-lipoxygenase activating protein ALOX5AP were associated with ischaemic stroke, whereas other studies reported ambiguous findings. We examined 932 ischaemic stroke patients from a Swedish population-based stroke register, and 396 control subjects. We assessed possible

Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain.

Neural stem cells (NSCs) have attracted major research interest due to their potential use in cell replacement therapy. In patients, human cells are the preferred choice, one source of human NSCs being the brain of fetuses. The aims of the present study were to explore the long-term differentiation, mobility and viability of NSCs derived from the human fetal striatum in response to intracerebral i

Collaborative Resolution of Requirements Mismatches When Adopting Open Source Components

Abstract in Undetermined[Context and motivation] There is considerable flexibility in requirements specifications (both functional and non-functional), as well as in the features of available OSS components. This allows a collaborative matching and negotiation process between stakeholders such as: customers, software contractors and OSS communities, regarding desired requirements versus available

Direct and inverse scattering in the time domain for a dissipative wave equation. Part 4: Use of phase velocity mismatches to simplify inversions

For pt.III see J. Math. Phys., vol.28, p.260 (1987). The one-dimensional inverse scattering problem is considered for lossy inhomogeneous media for the case in which the phase velocities at the two boundaries of the scatterer do not match that of the host medium. The model problem involves electromagnetic wave propagation in a medium of unknown thickness with spatially varying permittivity and con

IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE - a possible new treatment?

OBJECTIVE.: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in several organ systems, related to the presence of circulating and tissue-deposited immune complexes (ICs) which stimulate leukocytes through FcγRs with subsequent inflammation. Treatment with EndoS, an IgG glycan hydrolyzing bacterial enzyme from Streptococcus pyogenes, has shown benefi

Specific mediator inhibition by the NO donors SNP and NCX 2057 in the peripheral lung: implications for allergen-induced bronchoconstriction.

BACKGROUND: The aim of this study was to examine potential therapeutic effect of the two NO donors NCX 2057 (3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid) 4-(nitrooxy)butyl ester) and SNP (sodium nitroprusside) on the early allergic airway response in the peripheral lung. METHODS: The experiments were performed in guinea pig lung parenchyma (GPLP) derived from ovalbumin (OVA) sensitized guinea p

Hemodynamics and jugular venous oxygen saturation during carotid endarterectomy: a comparison between general and locoregional anesthesia.

AIM: To study hemodynamic and blood oxygenation changes in patients undergoing carotid endarterectomy (CEA) under general (GA) or locoregional (LRA) anesthesia. METHODS: Prospective non-randomized study including 50 patients undergoing CEA (31 men, mean age 72 (range 50-84) years-old under GA (N.=23) or LRA (N.=27). Systemic blood pressure, ECG, venous oxygen saturation in the ipsilateral jugular

Enterolactone and breast cancer: methodological issues may contribute to conflicting results in observational studies.

Lignans found in plant foods are converted by the intestinal microflora to enterolignans. The structure of enterolignans is similar to that of estrogens, which has inspired researchers to examine a potential protective association in relation to health outcomes. Numerous epidemiological studies have measured concentration of enterolignans, mainly enterolactone, in blood or urine as a biomarker of

Acceleration and rotation in a pendulum ride, measured using an iPhone 4

Many modern cell phones have built-in sensors that may be used as a resource for physics education. Amusement rides offer examples of many different types of motion, where the acceleration leads to forces experienced throughout the body. A comoving 3D-accelerometer gives an electronic measurement of the varying forces acting on the rider, but a complete description of a motion also requires measur

Malignant disease in the haemophilic population: moving towards a management consensus?

The Malignancy in Haemophilia Workshop Group convened a consensus working group of haematologists and oncologists to review topics related to malignancy in haemophilia. The treatment of malignant disease in this population is increasingly relevant as both outcome and lifespan continue to improve. Although adequate guidance exists for control of spontaneous bleeding episodes and of haemostasis in g

Is administration of gadolinium-based contrast media to pregnant women and small children justified?

The use of gadolinium-based contrast media in pregnant or lactating women has been discouraged at many radiology departments due to the lack of knowledge of the risks for the fetus and the unwillingness to expose neonates to unnecessary drugs. In the present review the current literature and present guidelines regarding the use of gadolinium-based contrast media have been reviewed to validate the

Organic amendments as strategy to increase organic matter in particle-size fractions of a semi-arid soil

The distribution of organic matter (OM) in soil particle-size fractions is a key process in the dynamic and persistence of soil organic carbon. In order to study the distribution of organic amendments among the different soil particle-size fractions in a semi-arid, degraded soil (a sandy loam Haplic Regosol), a 9-month-incubation experiment was carried out after the application of composted organi

Haemodynamic effetcts of prenaterol and cardiac glycosides in patients with recent myocardial infarctions

Prenalterol was given to twenty five patients with acute myocardial infarction. Thirteen patients (group B) had signs of cardiac decompensation while twelve (group A) had not. Ejection fraction was determined with 99mTc-labelled red blood cells before and after prenalterol (50 μg kg-1 body weight), intravenously. In group B this procedure was repeated after digitalization 2 days later. The ejectio