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Pure science or policy involvement? Ambiguous boundary-work for Swedish carbon cycle science
In theory, the interaction between the worlds of environmental science and policy may seem straightforward. From a realm outside politics and power, scientists provide relevant knowledge about nature upon which informed policy decisions could be based. However, in reality this linear model tends to be replaced by a much more complex relationship where the distinction between facts and values, know
Radical prostatectomy - why?
Identification of a GH110 subfamily of alpha 1,3-galactosidases - Novel enzymes for removal of the alpha 3Gal xenotransplantation antigen
In search of alpha-galactosidases with improved kinetic properties for removal of the immunodominant alpha 1,3-linked galactose residues of blood group B antigens, we recently identified a novel prokaryotic family of alpha-galactosidases (CAZy GH110) with highly restricted substrate specificity and neutral pH optimum (Liu, Q. P., Sulzenbacher, G., Yuan, H., Bennett, E. P., Pietz, G., Saunders, K.,
Neighbourhood social interactions and risk of acute myocardial infarction.
STUDY OBJECTIVE: Previous studies of neighbourhood effects on ischaemic heart disease (IHD) have used census or administrative data to characterise the residential context, most commonly its socioeconomic level. Using the ecometric approach to define neighbourhood social interaction variables that may be relevant to IHD, neighbourhood social cohesion and safety were examined to see how they relate
Gene-specific expression and calcium activation of Arabidopsis thaliana phospholipase C isoforms
PI-PLCs synthesise the calcium releasing second messenger IP3. We investigated the expression patterns of the Arabidopsis PI-PLC gene family and measured in vitro activity of encoded enzymes. Gene specific RT-PCR and promoter-GUS fusions were used to analyse AtPLC gene expression patterns. The five available AtPLC cDNAs were expressed as fusion proteins in Escherichia coli. All members of the AtPL
3D reconstruction for a multi-ring PET scanner by single-slice rebinning and axial deconvolution.
Randomized clinical trial of the effect of interferon alpha on survival in patients with disseminated midgut carcinoid tumours
Background: Midgut carcinoid tumours often present with widespread disease making curative surgery impossible. Medical treatment therefore plays a major role in the treatment of these patients. Methods: In this prospective randomized study, the effect of interferon (IFN) alpha on survival and risk of tumour progression was evaluated in 68 patients with midgut carcinoid tumours metastatic to the li
Functional balance performance in patients with Parkinson's disease after long-term treatment with subthalamic nucleus high-frequency stimulation
The aim was to investigate if functional balance performance in patients with Parkinson's disease (PD) was affected by long-term (3 years) treatment with bilateral subthalamic nucleus (STN) high-frequency stimulation. Thirty-five patients were consecutively included, and 28 patients completed the study (mean age 62 years, SD 6.5). The Berg Balance Scale (BBS) was assessed preoperatively and 1 and
Ultra-relativistic heavy-ion experiments at RHIC and LHC
The RHIC collider, the experiments and some selected results from the first round of running are presented and discussed. The LHC collider and the ALICE experiment, which are under construction, are also reviewed and discussed in this paper.
virF-positive Yersinia pseudotuberculosis and Yersinia enterocolitica found in migratory birds in Sweden
During spring and autumn migrations, 468 fecal samples from 57 different species of migratory birds were collected in Sweden. In total, Yersinia spp. were isolated from 12.8% of collected samples. The most commonly found species was Yersinia enterocolitica, which was isolated from 5.6% of all collected samples, followed by Y. intermedia (3.8%), Y. frederiksenii (3.0%), Y kristensenii (0.9%), Y. ps
VEGF inhibition for retinal diseases. The Swedish experience (Abstracts of the XXXVIII Nordic Congress of Ophthalmology 14-17 June 2008)
Direct electron transfer at cellobiose dehydrogenase modified anodes for biofuel cells
Cellobiose dehydrogenases (CDHs, EC 1.1.99.18) contain a larger flavin-associated (dehydrogenase) domain and a smaller heme-binding (cytochrome) domain. CDHs from basidiomycete fungi oxidize at an appreciable level cellobiose, cellodextrins, and lactose, and those from ascomycetes may additionally oxidize some monosaccharides to their corresponding lactones at the flavin domain. CDHs are able to c
Rain flow cycle distributions for fatigue life prediction under Gaussian load processes
We present a new and simple definition of the Rain Flow Cycle count method for the analysis of a random load process. It is combined with the Palmgren-Miner damage rule, and a stochastic model for the fatigue life and fatigue limit variability. Algorithms are presented which make it possible to calculate the RFC-amplitude distribution, based on a Markov Chain approximation of local maxima and mini
Magnesium chelatase: association with ribosomes and mutant complementation studies identify barley subunit Xantha-G as a functional counterpart of Rhodobacter subunit BchD
Magnesium chelatase catalyses the insertion of Mg2+ into protoporphyrin and is found exclusively in organisms which synthesise chlorophyll or bacteriochlorophyll. Soluble protein preparations containing >10 mg protein/ml, obtained by gentle lysis of barley plastids and Rhodobacter sphaeroplasts, inserted Mg2+ into deuteroporphyrin IX in the presence of ATP at rates of 40 and 8 pmoles/mg protein pe
Letter from the president.
Boronate-containing copolymers: Polyelectrolyte properties and sugar-specific interaction with agarose gel
Copolymers of N-acryloyl-m-aminophenylboronic acid (NAAPBA) with acryamide (AA), N,N-dimethylacrylamide (DMAA), and N-isopropylacrylamide (NIPAM) were found to adsorb on cross-linked agarose gel (Sepharose CL-6B) in the pH range from 7.5-9.2, due to specific boronate-sugar interactions. The molar percentages of phenylboronic acid (PBA) groups in the boronate-containing copolymers (BCCs), as estima
Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation
To determine which chemokine receptors might be involved in T lymphocyte localization to the intestinal mucosa, we examined receptor expression on human intestinal lamina propria lymphocytes (LPL), intraepithelial lymphocytes (IEL) and CD45RO+beta7hi gut homing peripheral blood lymphocytes (PBL). Virtually all LPL and IEL expressed CXCR3 and CCR5, receptors that have been associated with Th1(Tc1)/
Graft survival benefit to be expected of new immunosuppressive regimens
Autoionization studies of the 1s2s2p 4P5/2 levels in He-, Li i, and Be ii
Autoionization rates of the 1s2s2p4P5/2 level are computed for He-, Li I, and Be II, using the golden-rule formalism in the multiconfiguration Hartree-Fock approximation. The main objective is to clarify ambiguities concerning the metastable 4P5/2 component in He-, whose lifetimes differ significantly in various works. The present calculations reveal a much shorter lifetime, 345 mus, than predicte