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Room temperature X-ray absorption spectroscopy of metalloenzymes with drop-on-demand sample delivery at XFELs

X-ray crystallography and X-ray spectroscopy using X-ray free electron lasers plays an important role in understanding the interplay of structural changes in the protein and the chemical changes at the metal active site of metalloenzymes through their catalytic cycles. As a part of such an effort, we report here our recent development of methods for X-ray absorption spectroscopy (XAS) at XFELs to

Resisting the epistemic argument for compatibilism

In this paper, we clarify, unpack, and ultimately resist what is perhaps the most prominent argument for the compatibility of free will and determinism: the epistemic argument for compatibilism. We focus on one such argument as articulated by David Lewis: (i) we know we are free, (ii) for all we know everything is predetermined, (iii) if we know we are free but for all we know everything is predet

No impact of parental singing during the neonatal period on cognition in preterm-born children at 2–3 years

Aim: Studies examining the long-term effects of neonatal music interventions on the cognition of children born preterm are scarce. We investigated whether a parental singing intervention before term age improves cognitive and language skills in preterm-born children. Methods: In this longitudinal, two-country Singing Kangaroo, randomised controlled trial, 74 preterm infants were allocated to a sin

The performance of protest : Las tesis and the new feminist radicality at the conjunction of digital spaces and the streets

In this article, I conduct a multimodal analysis of videos of Las Tesis’ performance “Un Violador En Tu Camino,” posted on YouTube and Twitter, with the aim of obtaining deeper insights into how digital platforms encourage the creation of large-scale, transnational feminist mobilizations and how the encounter with narratives of multiple violences can enable new types of feminist radicality. Rather

Serum proteome profiles in patients treated with targeted temperature management after out-of-hospital cardiac arrest

BACKGROUND: Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia-ischaemia and reperfusion. It may further explore intervention effects for new mechanistic insights, identify candidate prognostic protein biomarkers and potential therapeutic targets. This pilot study aimed to investigate serum proteome p