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Cost effectiveness of adding budesonide/formoterol to tiotropium in COPD in four Nordic countries

Objective: Assess the cost effectiveness of budesonide/formoterol (BUD/FORM) Turbuhaler (R) +tiotropium (TIO) HandiHaler (R) vs. placebo (PBO)+TIO in patients with chronic obstructive pulmonary disease (COPD) eligible for inhaled corticosteroids/long-acting beta(2)-agonists (ICS/LABA). Methods: The cost-effectiveness analysis was based on the 12-week, randomised, double-blind CLIMB trial. The stud

Photophysics of indole-2-carboxylic acid in an aqueous environment studied by fluorescence spectroscopy in combination with ab initio calculations.

The photo-physics and -chemistry of indoles are known to be highly complex and strongly dependent on their precise molecular structure and environment. Combination of spectroscopic analysis with quantum chemical calculations should be a powerful tool to unravel precise excited state deactivation mechanisms. At the same time, combined studies are seldom and likely far from trivial. In this work we

Use and misuse of PLFA measurements in soils

The determination of the phospholipid fatty acid (PLFA) pattern of soil organisms has become one of the most commonly used methods to study microbial community structure. Here we recapitulate the background of our work applying the PLFA method to soil in the early 1990s. We also stress that although the PLFA method was, and still is, a rapid and sensitive method to detect changes in the microbial

Studying cyborgs: re-examining internet studies as human subjects research

Virtual communities and social networks assume and consume more aspects of people's lives. In these evolving social spaces, the boundaries between actual and virtual reality, between living individuals and their virtual bodies, and between private and public domains are becoming ever more blurred. As a result, users and their presentations of self, as expressed through virtual bodies, are increasi

Analysis of the Agrotis segetum pheromone gland transcriptome in the light of sex pheromone biosynthesis

Background: Moths rely heavily on pheromone communication for mate finding. The pheromone components of most moths are modified from the products of normal fatty acid metabolism by a set of tissue-specific enzymes. The turnip moth, Agrotis segetum uses a series of homologous fatty-alcohol acetate esters ((Z)-5-decenyl, (Z)-7-dodecenyl, and (Z)-9 tetradecenyl acetate) as its sex pheromone component

Freeze-out radii extracted from three-pion cumulants in pp, p-Pb and Pb-Pb collisions at the LHC

In high-energy collisions, the spatio-temporal size of the particle production region can be measured using the Bose-Einstein correlations of identical bosons at low relative momentum. The source radii are typically extracted using two-pion correlations, and characterize the system at the last stage of interaction, called kinetic freeze-out. In low-multiplicity collisions, unlike in high-multiplic

Leadership On Demand: Followers as initiators and inhibitors of managerial leadership

A key aspect of leadership is the followers’ constructions of its value and relevance. Based on two empirical, qualitative case studies, this paper highlights the importance of the ‘demand’ for leadership when leader–follower relationships are established. We further discuss how followers influence, inhibit and initiate managerial leadership (i.e. leadership acts from their formal superior targeti

Flow sensing in the cardiovascular system

Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte hepara

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Steven Spielberg's film Saving Private Ryan is at the centre of this text, with a particular focus on how it displays the past in ways that place the audience in the middle of the historical action. By looking at various technical breakthroughs predating this film, it is argued that what we here see is the beginning of a new kind of 360-degree historiography that nowadays dominates historical epic

Dynamically evolving Gaussian spatial fields

We discuss general non-stationary spatio-temporal surfaces that involve dynamics governed by velocity fields. The approach formalizes and expands previously used models in analysis of satellite data of significant wave heights. We start with homogeneous spatial fields. By applying an extension of the standard moving average construction we obtain models which are stationary in time. The resulting

Levels of Beta-Microseminoprotein in Blood and Risk of Prostate Cancer in Multiple Populations.

BackgroundA common genetic variant (rs10993994) in the 5' region of the gene encoding β-microseminoprotein (MSP) is associated with circulating levels of MSP and prostate cancer risk. Whether MSP levels are predictive of prostate cancer risk has not been evaluated.MethodsWe investigated the prospective relationship between circulating plasma levels of MSP and prostate cancer risk in a nested case-

Generation of sigma,pi-furyl and thienyl ligands at di-iron centers via facile phosphorus-carbon bond cleavage: Synthesis and molecular structures of [Fe-2(CO)(6)(mu-eta(1),eta(2)-C4H3E){mu-P(C4H3E)(2)}] (E = O, S)

Treatment of [Fe-3(CO)(12)] with tri(2-furyl)phosphine (PFu(3)) or tri(2-thienyl)phosphine (PTh3) in dichloromethane at 40 degrees C leads to facile phosphorus carbon bond scission affording di-iron furyl- and thienyl-bridged complexes [Fe-2(CO)(6)(mu-eta(1),eta(2)-C4H3E)(mu-P(C4H3E)(2))] (1 E = O, Fu; 3 E = S, Th) in good yields, together with smaller amounts of the phosphine-substituted [Fe-2(CO

The growth of exocrine pancreatic insufficient young pigs fed an elemental diet is dependent on enteral pancreatin supplementation

Young exocrine pancreas insufficient (EPI) pigs given a commercial feed (polymeric diet) show growth retardation that can be reversed by dietary supplementation with pancreatic enzymes. Our aim was to investigate if providing an elemental diet, mimicking a pre-digested diet, can support body growth in EPI-pigs. Thus, EPI-pigs, pancreatic duct-ligated at 12.2 +/- 2.6 weeks of age (15.3 +/- 4.8 kg),

Low-temperature ferroelectric phase and magnetoelectric coupling in underdoped La2CuO4+x

We report the discovery of ferroelectricity below 4.5 K in highly underdoped La2CuO4+x accompanied by slow charge dynamics which develop below T similar to 40 K. An anisotropic magnetoelectric response has also been observed, indicating considerable spin-charge coupling in this lightly doped parent high-temperature copper-oxide superconductor. The ferroelectric state is proposed to develop from po

Minimal Contribution of Fasting Hyperglycemia to the Incidence of Type 2 Diabetes in Subjects With Normal 2-h Plasma Glucose

OBJECTIVE - To assess the relative contribution of increased fasting and postload plasma glucose concentrations to the incidence of type 2 diabetes in subjects with a normal 2-h plasma glucose concentration. RESEARCH DESIGN AND METHODS - A total of 3,450 subjects with 2-h plasma glucose concentration < 140 mg/dl at baseline were followed up in the San Antonio Heart Study (SAHS) and the Botnia Stud

Genetic regulation of parasite infection: empirical evidence of the functional significance of an IL4‐gene SNP on nematode infections in wild primates

Background Susceptibility to parasite infection affects fitness-related processes, such as mate choice and survival, yet its genetic regulation remains poorly understood. Interleukin-4 (IL4) plays a central role in the humoral immune defence against nematode parasite infections, inducing IgE switch and regulation of worm expulsion from the intestines. The evolutionary and functional significance