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A dose based approach for evaluation of inter-observer variations in target delineation

Background and purpose: Substantial inter-observer variations in target delineation have been presented previously. Target delineation for paediatric cases is difficult due to the small number of children, the variation in paediatric targets, the number of study protocols, and the individual patient's specific needs and demands. Uncertainties in target delineation might lead to under-dosage or ove

Self-reported impairments among people with late effects of polio : a mixed-methods study

OBJECTIVE: To determine how much people with late effects of polio are bothered by various impairments and their influence on everyday life. DESIGN: A mixed-methods design. SUBJECTS/PATIENTS: Seven women and 7 men (mean age 70 years) with late effects of polio. METHODS: Self-reported Impairments in Persons with late effects of Polio (SIPP) scale and face-to-face interviews. In SIPP, the participan

Corona hotar förvärra svenska bostadskrisen : 108 forskare: Sveriges regering och kommuner måste förhindra en katastrof

DEBATE. Far from everyone who lives in Sweden has a secure housing situation. According to the National Board of Health and Welfare's latest national survey of 2017, there are about 33,000 homeless people in the country. A significant proportion of them are children. Due to the ongoing corona pandemic, many households are now threatened by unemployment and a deteriorating economy. If the state and

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Antimicrobial resistance (AMR) has come to prominence as a priority for policy makers and healthcare professionals. There are many well-described guidelines on how healthcare professionals should handle AMR. However, professional practices are sometimes different from what the guidelines prescribe. Based on a non-scientific case, the article explores and discusses healthcare professionals’ practicAntimicrobial resistance (AMR) has come to prominence as a priority for policy makers and healthcare professionals. There are many well-described guidelines on how healthcare professionals should handle AMR. However, professional practices are sometimes different from what the guidelines prescribe. Based on a non-scientific case, the article explores and discusses healthcare professionals’ practic

Animated lands : Studies in Territoriology

In Animated Lands Andrea Mubi Brighenti and Mattias Kärrholm focus on territory as a living phenomenon—and territoriality as an active and constantly reshaping force. They explore the complexity of territorial production through a series of parallel investigations into fundamental territorial themes, such as rhythm, synchronization, melody, morphogenesis, and animism.The notion of territory is exc

Patient Characteristics Influence Activated Signal Transducer and Activator of Transcription 3 (STAT3) Levels in Primary Breast Cancer—Impact on Prognosis

Background: Activated signal transducer and activator of transcription 3 (pSTAT3) is often present in breast cancer, but its prognostic impact is still unclear. We investigated how breast tumor-specific pSTAT3Y705 levels are associated with patient and tumor characteristics and risk of recurrence. Materials and Methods: Primary breast cancer patients without preoperative treatment were included pr

Tumour suppressor 15-hydroxyprostaglandin dehydrogenase induces differentiation in colon cancer via GLI1 inhibition

Inflammation is an established risk factor for colorectal cancer. We and others have shown that colorectal cancer patients with elevated cysteinyl leukotriene receptor 2 (CysLT2R) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) levels exhibit good prognoses. However, both CysLT2R and 15-PGDH, which act as tumour suppressors, are often suppressed in colorectal cancer. We previously reported tha

Alternative biomarkers for classification of latent tuberculosis infection status in pregnant women with borderline Quantiferon plus results

Borderline interferon-gamma (IFN-γ) results (near the cut-off level 0.35 IU/ml) occur in QuantiFERON (QFT) assays. We investigated the performance of alternative biomarkers for classification of latent tuberculosis infection (LTBI) status in pregnant women with borderline QFT IFN-γ responses. Pregnant women (n = 96) were identified from a cohort study in Ethiopia, based on QFT-Plus IFN-γ results (

Patients’ perspective in the context of proton beam therapy : summary of a Nordic workshop

Introduction: On 15–16 November 2019, the Skandion Clinic in Sweden hosted the first Nordic workshop on ‘Patients’ perspective in proton beam therapy’. The workshop was conducted to describe and compare the patient care in PBT clinics in the Nordic countries and to initiate a collaboration, with the target to ensure patient participation and reduce the risk of inequity of access by lowering the ba

Voicing on the borders of language

My research engages with the varieties of relationship between verbal and non-verbal forms of language and communication. I approach the issue through three people who live or work with non-verbal people on the autistic spectrum: Phoebe Caldwell, Fernand Deligny and Iris Johansson. Their practices bring singular perspectives to my core question: How can we (re)conceive and engage with non-verbal f

On damage detection system information for structural systems

Damage detection systems (DDSs) provide information on the integrity of structural systems in contrast to local information from inspections or non-destructive testing (NDT) techniques. In this paper, an approach is developed that utilizes DDS information to update structural system reliability and integrate this information into risk and decision analyses. The approach includes a novel performanc