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The Struggle for History: Lindsay Anderson Teaches Free Cinema

In spring 1986, Lindsay Anderson appeared in a television programme on British cinema. This was part of a series of three under the heading British Cinema: Personal View, produced by Thames Television. Anderson’s contribution, Free Cinema 1956–? An Essay on Film by Lindsay Anderson, was written and directed by him. He was also the star of the programme, providing a lecture on the history of Britis

Conformational dynamics and thermodynamics of protein-ligand binding studied by NMR relaxation.

Protein conformational dynamics can be critical for ligand binding in two ways that relate to kinetics and thermodynamics respectively. First, conformational transitions between different substates can control access to the binding site (kinetics). Secondly, differences between free and ligand-bound states in their conformational fluctuations contribute to the entropy of ligand binding (thermodyna

M1 Protein-Dependent Intracellular Trafficking Promotes Persistence and Replication of Streptococcus pyogenes in Macrophages

Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emphasized. In patients with deep tissue infections, an intracellular reservoir of S.

The Psychosocial Atmosphere in Community-Based Activity Centers for People with Psychiatric Disabilities: Visitor and Staff Perceptions.

This study investigated how visitors and staff in community-based activity centers in Sweden perceived the psychosocial atmosphere and whether this could be explained by the centers' orientation (work-oriented versus meeting place-oriented centers). Eighty-eight visitors and 37 staff members at three work-oriented and three meeting place-oriented centers participated. The Community-oriented Progra

Ovarian Cancer and Body Size: Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies

Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with o

Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9.

Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, we report CRISPR/Cas9 targeting of two clinically relevant genes, B2M and CCR5, in primary human CD4(+) T cells and CD34(+) hematopoietic stem and progenitor cells (HSPCs). Use

Quality in e-learning - a conceptual framework based on experiences from three international benchmarking projects

Between 2008 and 2010, Lund University took part in three international benchmarking projects, E-xcellence+, the eLearning Benchmarking Exercise 2009, and the First Dual-Mode Distance Learning Benchmarking Club. A comparison of these models revealed a rather high level of correspondence. From this finding and from desktop studies of the current discourse regarding e-learning, a conceptual framewor

Angiomatoid fibrous histiocytoma a series of five cytologic cases with literature review and emphasis on diagnostic pitfalls

Angiomatoid fibrous histiocytoma (AFH) is an uncommon and mostly indolent soft tissue neoplasm, which usually occurs in the subcutaneous tissue of the extremities in children and young adults. Although the histologic features of AFH are well established, reports of its cytomorphology are very limited. This report characterizes the cytomorphologic features of five cases of AFH, with correlation to

Constructal Theory Based Geometric Optimization of Wavy Channels in the Low Reynolds Number Regime

To obtain better fluid mixing and higher heat transfer in the low Reynolds number regime, various wavy fins are employed in heat sinks (heat exchangers) for electronic cooling applications. However, it was reported in previous works that in the low Reynolds number regime there are no remarkable differences in the thermal performance of a straight-plate and a wavy-wall channel. In this study, the c

An Adaptive Penalty Multi-Pitch Estimator with Self-Regularization

This work treats multi-pitch estimation, and in particular the common misclassification issue wherein the pitch at half the true fundamental frequency, the sub-octave, is chosen instead of the true pitch. Extending on current group LASSO-based methods for pitch estimation, this work introduces an adaptive total variation penalty, which enforces both group- and block sparsity, as well as deals with

Estimated glomerular filtration rate is associated with major bleeding complications but not thromboembolic events, in anticoagulated patients taking warfarin.

BACKGROUND: Decreased glomerular filtration rate is an established risk factor for bleeding but there are limited data on its association with bleeding risk in well-controlled anticoagulated patients taking warfarin. OBJECTIVES: The aim was to investigate the relationship between glomerular filtration rate, major bleeding and thromboembolic complications in patients with tight anticoagulation cont

Plant roles: Site competence bundles and their relationships with site location factors and performance

Purpose - The purpose of this paper is to investigate the strategic role of plants, in terms of the type and level of site competence, the relationship with the strategic reason for location, and the impact on operational performance. Design/methodology/approach - The authors use a survey of 103 Swedish manufacturing plants that belong to global production networks and analyze patterns within this

Biomarkers and proteomic analysis of osteoarthritis.

Our friend and colleague, Dr. Dick Heinegård, contributed greatly to the understanding of joint tissue biochemistry, the discovery and validation of arthritis-related biomarkers and the establishment of methodology for proteomic studies in osteoarthritis (OA). To date, discovery of OA-related biomarkers has focused on cartilage, synovial fluid and serum. Methods, such as affinity depletion and hya

High catechins/low caffeine powder from green tea leaves by pressurized liquid extraction and supercritical antisolvent precipitation

This paper reports a method to produce a solvent-free extract from green tea leaves with high content of catechins and low content of caffeine, in two steps and using only "green" solvents. The method is based on the pressurized liquid extraction (PLE) of the green tea leaves using ethyl lactate as solvent, followed by a selective precipitation procedure using the supercritical carbon dioxide (SCC

Relationship between knee pain and the presence, location, size and phenotype of femorotibial denuded areas of subchondral bone as visualized by MRI

Objective: Conflicting associations between imaging biomarkers and pain in knee osteoarthritis (OA) have been reported. A relation between pain and denuded areas of subchondral bone (dABs) has been suggested and this study explores this relationship further by relating the presence, phenotype, location and size of dABs to different measures of knee pain. Methods: 633 right knees from the Osteoarth

Overlapping multiple object assignments

This paper studies an allocation problem with multiple object assignments, indivisible objects, no endowments and no monetary transfers. Agents have complete, transitive and strict preferences over bundles of objects. A rule assigns objects to agents. A single object may be assigned to several agents as long as the agents satisfy a compatibility constraint. If no restrictions are imposed on the co

Tungsten spectroscopy at the Livermore electron beam ion trap facility

The utilization of tungsten spectroscopy for diagnostics of magnetically confined fusion plasmas requires the radiative properties of tungsten ions to be accurately known. At the Lawrence Livermore National Laboratory, a program to gather spectroscopic data on tungsten ions has been initiated with the purpose to study spectral signatures and identify candidate fusion plasma diagnostics. In this pa

Why Anticorruption Reform Fails: Systemic Corruption as a Collective Action Problem

With an increased awareness of the detrimental effects of corruption on development, strategies to fight it are now a top priority in policy circles. Yet, in countries ridden with systemic corruption, few successes have resulted from the investment. On the basis of an interview study conducted in Kenya and Uganda—two arguably typically thoroughly corrupt countries—we argue that part of an explanat

Fully aromatic ionomers with precisely sequenced sulfonated moieties for enhanced proton conductivity

Abstract in UndeterminedA series of six fully aromatic ionomers with precisely sequenced sulfonated sites along the polymer chains have been designed, prepared and characterized as proton-exchange membranes. Two straight-forward and efficient synthetic strategies based on Ullmann ether reactions and a Baeyer-Villiger rearrangement were devised to obtain bisphenol monomers with four or six phenylen