Biopharmaceuticals are a fast-growing niche in the pharmaceutical industry compared to small molecules. Even though a lot of progress has been made in recent years, the process to take a drug candidate to clinical trials can be lengthy and the selection process of high producing stable clones can be an arduous process. In this master thesis the design of new expression vectors for the production

The project was aimed at numerically assessing exoplanetary systems to distinguish their capabilities of hosting additional planets. The shortcomings of the radial velocity method sometimes causes hindrance in the detection of terrestrial planets. Although modern spectrometers have evolved and improved drastically, the process of distinguishing signals from smaller planets is still difficult and c

In 2017 Sweden's government changed the compensation levels for the municipalities' reception of unaccompanied refugees’ children to a level hoped to stimulate the municipalities to find cheaper solutions. The aim of this study was therefore to explore how social workers responded, managed and navigated under rapidly changing institutional conditions in order to analyze whether it was poss

Bakgrund: Varje år bedöms 70000 - 75000 personer i Sverige behöva palliativ vård. En stor av del dessa är patienter med cancersjukdomar. Palliativ vård innebär att ge patienten god livskvalitet in i det sista. Syfte: Att undersöka om en tidig start av palliativ vård kan påverka livskvaliteten hos cancerpatienter. Metod: Metoden var en icke systematisk litteraturstudie där åtta artiklar granskades

Over 30 % of all deaths worldwide are related to cardiovascular diseases and they are the leading cause of death. Therefore, research into treatment, diagnosis and prognostication of these diseases are of critical importance. One way to examine the cardiovascular system is through the use of Magnetic Resonance Imaging (MRI). The aim of this thesis is to create a model using the Deep Learning arc

As the COVID-19 pandemic spread across the globe, unprecedented policy measures were implemented by central banks and governments to dampen the effect on the real economy. Alongside the spread of the pandemic, research regarding how to simulate similar effects of the virus on the real economy and how to formulate optimal policy began spreading at an equal pace. The aim of this thesis is twofold. I

Utgångspunkten för examensarbetet är den ökande turismen i fjällvärlden. Med tomt 5:544 i Sälenfjällen som huvudfokus undersöker projektet platsens förutsättningar i klimat, historia och arkitektur samt fjällturismens utveckling under 1900-talet. Analysen ligger sedan grund till en utforskande process i skiss och modell för att nå fram till arkitektoniska principer för att bygga i svensk fjällmiljThis thesis is based in the expanding tourism industry of northern Sweden. Through site 5:544 in Sälenfjällen, the project investigates the conditions in terms of climate, history, and architecture of the area as well as the development of nature tourism in north Sweden in the 20th century. The analysis results in an investigation process through physical models and sketches to reach a set of tect

Enligt prognoser från FN kommer världens befolkning att vara mellan 9,6 och 13,2 miljarder till år 2100. Samtidigt ökar den globala ekonomiska tillväxten och urbaniseringen där U-länder övergår till I-länder. Befolkningstillväxt och konsumtion ökar parallellt, vilket innebär en betydande påfrestning på jordens naturresurser. Även om Sverige har en god avfallshantering jämfört med andra europeiska Even though Sweden has a good waste management system compared to other European countries there is still much to be done in the prevention sector. The science shows that there are huge environmental benefits with waste prevention compared to recycling for example. There have been studies that analysed the Swedish national and municipal waste prevention plans that suggest there is a problem where

The purpose of this study is to explore how the board of directors perform risk oversight, providing a greater insight into what the board of directors actually do in the risk oversight process. The authors seek to map and investigate the practical part of the board's work in overseeing an entity’s risks and how it relates to theory. The research applies a mixed method approach, using both qua

En differentialekvation beskriver en funktion där förändringshastigheten beror på funktionsvärdet. Som ett exempel kan nämnas befolkningstillväxt, där tillväxthastigheten (i form av födslar) kommer att vara högre för en större befolkning. Numerisk lösning av en differentialekvation innebär att givet ett visst startvärde förutsäga funktionsvärdet vid en senare tidpunkt med tillräckligt god noggrannThis thesis offers an overview of the relatively new family of Rosenbrock-Krylov numerical methods for ODEs. These methods are a further development of Rosenbrock methods, using a lower-dimension approximation of the Jacobian. The thesis gives the mathematical background to Rosenbrock-Krylov methods by first presenting Runge-Kutta methods and Rosenbrock methods, followed by the concept of Krylov s

dis thesis attempts to use qualitative research and sociological analysis to explore how demilitarization, which TEMPhas lasted for decades, may TEMPhas an impact on development in recent years. Mainly based on literature review and data analysis, dis thesis chose Costa Rica as teh background, for revealing national education status - as teh research object - to speculate on how demilitarization T

In this work spectroscopic methods have been used to determine the effect of fluorophores on protein affinity. Fluorophores are used in many different contexts to mark proteins, genes or antibodies. By marking a construct with a fluorophore, it is possible to follow the localization and function in a biological system, but it is not often investigated how the bound fluorophore could affect the mar

Background: Scoliosis is a condition where a person's spine is curved and rotated in three dimensions. In severe cases, surgery is needed to straighten the spine. Before such complex procedures, meticulous planning is needed. By performing a CT-scan, images of the spine can be acquired. From these images, it is possible to segment the spine in three dimensions to facilitate the preparation. Ho

The prospect of this degree project was to gain an understanding of how digital products can support spatial planning processes which are characterized by citizen engagement. The project explores how digital products can be developed – and used – with the aim of promoting communication between the municipality and citizens in Malmö. The end goal was to design a product which recognized citizens ex

This project has developed from the site and building conditions in an area of central Boden, a town in the inland north of Sweden. In post-war times, the city grew thanks to the military and regional hospital resulting in the development of the site Prästholmen that was realized true to the modernistic ideal of the time. Since then, Boden together with its inland neighbours, have struggled agai

The Bogong Moth, Agrotis Infusa, is a migratory moth native to South-Eastern Australia. These nocturnal insects migrate over more than 1000 km from their breeding grounds to caves in the Australian alps. To find their way during this migration, individuals of the species use several compass cues, both magnetic and celestial. This study aimed to investigate the ability of the moth to navigate after

ar. Enorma framsteg har gjorts de senaste decennierna i neonatalvården (vård för nyfödda barn) och omkring 80% av EPT-barn i Sverige överlever. Dessa framsteg innefattar bl.a. administrering av kortison för att påskynda lungmognaden, modern teknisk utrustning, bättre kunskaper om neonatala sjukdomar m.m. Globalt är överlevnaden av EPT-barn lägre i länder med sämre ekonomiska förutsättningar och däAim: To evaluate a pipeline for automatic MRI brain segmentation and volumetric tissue structure quantification in a cohort of extremely preterm infants. Methods: 13 extremely preterm neonates underwent MRI-scanning at a term equivalent age. Seven of these subjects had suitable MRI sequences and were analyzed in the pipeline. Segmentation of MRI brain images into brain tissue types and parcellati

Parkinson’s disease (PD) is the most common neurodegenerative disorder, characterized by slow progressive loss of dopamine (DA) neurons in the substantia nigra, located in the ventral midbrain. Although the relatively focal degeneration in PD makes it a good candidate for cell-based therapies, obtaining cell source on large scale clinical application remains a challenge. It has now been shown that

Enhancing Therapeutic Genes to cure Neurodegenerative diseases Alzheimer’s and Parkinson’s are the leading cause of neurodegenerative disease around the world. Research so far has only progressed towards reducing the symptoms linked with these diseases with no cure having been developed. Alzheimer’s and Parkinson’s share similar pathology in the way that they develop and form protein clumps which