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Assessing health-related quality of life (HRQoL) in survivors of out-of-hospital cardiac arrest : A systematic review of patient-reported outcome measures

Aim High quality evidence of out-of-hospital cardiac arrest (OHCA) survivors’ health-related quality of life (HRQoL) can measure the long-term impact of CA. The aim of this study was to critically appraise the evidence of psychometric quality and acceptability of measures used in the assessment of HRQoL in cardiac arrest survivors. Methods Systematic literature searches (2004–2017) and named autho

Numerical study of heat transfer enhancement due to the use of fractal-shaped design for impingement cooling

This paper describes a numerical analysis of a heat transfer enhancement technique that introduces fractal-shaped design for impingement cooling. Based on the gas turbine combustion chamber cooling, a fractal-shaped nozzle is designed for the constant flow area in a single impingement cooling model. The incompressible Reynolds-averaged Navier-Stokes equations are applied to the system using CFD so

Resolving the trade-off between visual sensitivity and spatial acuity - lessons from hawkmoths

The visual systems of many animals, particularly those active during the day, are optimized for high spatial acuity. However, at night, when photons are sparse and the visual signal competes with increased noise levels, fine spatial resolution cannot be sustained and is traded-off for the greater sensitivity required to see in dim light. High spatial acuity demands detectors and successive visual

Simulated time-lapse dc-IP monitoring of dense non-aqueous phase liquids (DNAPLs)-An Initial Approach

Geoelectrical techniques have long standing potential for imaging sites contaminated by dense non-aqueous phase liquids (DNAPLs). Recent work explored the effectiveness of time-lapse DC resistivity to monitor DNAPL source zone remediation. A fundamental component of the work was the development of a unique and comprehensive linkage between well-established DNAPL and DC resistivity models, with the

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and searched for the determinants of immune response variation. We found that age and sex affected the transcriptional respo

The pion mass and decay constant at three loops in two-flavour chiral perturbation theory

A calculation of the pion mass and decay constant at NNNLO in two-flavour chiral perturbation theory is presented. The results are cross-checked by using both the exponential and square root parametrizations of the Goldstone matrix field, as well as by comparing to the known leading log coefficients of the two quantities. A small numerical study of the quark mass dependence is performed, and for a

Measurements of top-quark pair differential cross-sections in the lepton+jets channel in pp collisions at √s=13 TeV using the ATLAS detector

Measurements of differential cross-sections of top-quark pair production in fiducial phase-spaces are presented as a function of top-quark and tt¯ system kinematic observables in proton-proton collisions at a centre-of-mass energy of s=13 TeV. The data set corresponds to an integrated luminosity of 3.2 fb−1, recorded in 2015 with the ATLAS detector at the CERN Large Hadron Collider. Events with ex

Yeast-bacteria competition induced new metabolic traits through large-scale genomic rearrangements in Lachancea kluyveri

Large-scale chromosomal rearrangements are an important source of evolutionary novelty that may have reshaped the genomes of existing yeast species. They dramatically alter genome organization and gene expression fueling a phenotypic leap in response to environmental constraints. Although the emergence of such signatures of genetic diversity is thought to be associated with human exploitation of y

Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes : the GENOMOS study

BACKGROUND: Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-lar

Linkage disequilibrium between polymorphisms in the human TNFRSF1B gene and their association with bone mass in perimenopausal women

Osteoporosis is a multifactorial disease with a strong genetic component characterized by reduced bone density and increased fracture risk. A candidate locus for regulation of hip bone mineral density (BMD) has been identified on chromosome 1p36 by linkage analysis. One of the positional and functional candidate genes located within this region is the tumour necrosis factor receptor superfamily me

Genetic and environmental determinants of peak bone mass in young men and women

Peak bone mass is an important risk factor for the development of osteoporosis in later life. Previous work has suggested that genetic, intrauterine, and environmental factors all contribute to the regulation of bone mass, but the ways in which they interact with each other to do so remain poorly understood. In this study, we investigated the relationship between peak bone mass and polymorphisms o

Association between COLIA1 Sp1 alleles and femoral neck geometry

Genetic factors play an important role in the pathogenesis of osteoporosis by affecting bone mineral density and other predictors of osteoporotic fracture risk such as ultrasound properties of bone and skeletal geometry. We previously identified a polymorphism of a Sp1 binding site in the Collagen Type 1 Alpha 1 gene (COLIA1) that has been associated with reduced BMD and an increased risk of osteo

Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women : no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms

BACKGROUND: Polymorphisms in the apolipoprotein E (APOE) gene are associated with fracture risk, and a potential mechanism is through vitamin K transport.OBJECTIVE: We investigated the relation between dietary vitamin K(1) intake, APOE polymorphisms, and markers of bone health.DESIGN: We measured bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN) in a cohort of Scottish wome

Large-scale population-based study shows no evidence of association between common polymorphism of the VDR gene and BMD in British women

UNLABELLED: The VDR is a candidate gene for osteoporosis. Here we studied five common polymorphisms of VDR in relation to calcium intake and vitamin D status in a population-based cohort of 3100 British women, but found no significant association with bone mass, bone loss, or fracture.INTRODUCTION: Population studies of vitamin D receptor (VDR) polymorphisms have produced conflicting results. We p