A 'multiscale' assessment of the molecular mechanisms underlying the pro-survival Bcl-2 protein members in cancer
Apoptosis is a vital physiological defence mechanism against tumorigenesis and critical for embryogenesis, tissue homeostasis, and discharging damaged or infected cells. Protein members of the B-cell lymphoma-2 (Bcl-2) family regulates the cellular commitment to cell survival or programmed cell death by intrinsic (mitochondrial) apoptosis. In response to intracellular stresses, this apoptotic bala