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Zoom-in array comparative genomic hybridization (aCGH) to detect germline rearrangements in cancer susceptibility genes.

Disease predisposing germline mutations in cancer susceptibility genes may consist of large genomic rearrangements, including deletions or duplications that are challenging, to detect and characterize using standard PCR-based mutation screening methods. Such rearrangements range from single exons up to hundreds of kilobases of sequence in size. Array-based comparative genomic hybridization (aCGH)

Retainers and retirement : Pieter Bruegel (†1566), pensioner in Sint-Janshuis retirement home, Bergen op Zoom

In 1553-1554 one Pieter Bruegel purchased a corrody in Sint-Janshuis, a retirement home for former employees of the Marquises of Bergen, where he would receive necessities of life and a place to stay until he would pass away. The paper reconstructs the early financial history of the retirement home, demonstrating how it was unable to cope with inflation, and struggled to provide for the inmates. I