Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but insights into its underlying biological mechanisms and treatments to preserve it are limited. Here we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in about 200,000 women of European ancestry. These common alleles were associated

Background: As the volume of surgical cases in low-and middle-income countries (LMICs) increases, surgical-site infections (SSIs) are becoming more prevalent with anecdotal evidence of antimicrobial resistance (AMR), despite a paucity of data on resistance patterns. Objectives: As a primary objective, this prospective study aimed to describe the epidemiology of SSIs and the associated AMR among wo

To find a systematic method for measuring and describing perception of human environment groups of subjects rated various environments with descriptive words, which were given the form of rating scales. Data was processed by means of factor analysis, through which eight main dimensions were obtained. Some of these dimensions were used in an attempt to compare different methods for presentation of

This paper focuses on language practices in multilingual English as a foreign language (EFL) classrooms in lower-secondary education. Based in the Ethnography of Language Policy, it presents a case study of a lead teacher of EFL and a year-8 class in a large urban multilingual school in Sweden. The study aims to map and understand language practices used in this classroom as being part of a larger

Classroom language ecologies are increasingly diverse as a result of mobility, migration, and information technology. In these spaces, interlocutors may draw upon shared linguistic and cultural resources but also bring in others. Prime examples are additional-language (AL) classrooms, where there is a shared target language, but where students may have different first languages from their classmat

Strategic communication as a research field and a professional practice is becoming increasingly relevant for organizations. Bringing together contributions from almost 60 leading international scholars, this dynamic Research Handbook on Strategic Communication is a timely contribution to a vivid and developing academic field.Divided into three key parts – fundamentals, perspectives, and processes

AimImpaired vibrotactile sense, mirroring diabetic peripheral neuropathy, is present among children and adolescents with type 1 diabetes. This study aims to re-examine the vibrotactile sense of paediatric type 1 diabetes subjects in order to evaluate any alterations in the vibrotactile sense over time.MethodsA VibroSense Meter I device was used to determine the vibrotactile perception thresholds (

The function of astrocytes intertwines with the extracellular matrix, whose neuron and glial cell-derived components shape neuronal plasticity. Astrocyte abnormalities have been reported in the brain of the mouse model for fragile X syndrome (FXS), the most common cause of inherited intellectual disability, and a monogenic cause of autism spectrum disorder. We compared human FXS and control astroc

We consider dynamical systems (X, T, μ) which have exponential decay of correlations for either Hölder continuous functions or functions of bounded variation. Given a sequence of balls (Bn)n=1∞, we give sufficient conditions for the set of eventually always hitting points to be of full measure. This is the set of points x such that for all large enough m, there is a k< m with Tk(x) ∈ Bm. We also g

Brain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetr

During and after the war in Croatia in the 1990’s, almost half of the 6000 partisan monuments erected between 1945 and 1990 were demolished. National sentiments ran high and these monuments were perceived as tokens of the regime that attacked Croatia in order to deny it independence. Most of these monuments were in places were fighting in the Second World War had taken place. In other regions, the

Accurate and efficient quantum control in the presence of constraints and decoherence is a requirement and a challenge in quantum information processing. Shortcuts to adiabaticity, originally proposed to speed up the slow adiabatic process, have nowadays become versatile toolboxes for preparing states or controlling the quantum dynamics. Unique shortcut designs are required for each quantum system

Aqueous sodium hydroxide solutions are extensively used as solvents for lignin in kraft pulping. These are also appealing systems for cellulose dissolution due to their inexpensiveness, ease to recycle and low toxicity. Cellulose dissolution occurs in a narrow concentration region and at low temperatures. Dissolution is often incomplete but additives, such as zinc oxide or urea, have been found to

Intrinsically disordered proteins (IDPs) are involved in many biological processes such as signalling, regulation and recognition. One of the main questions regarding IDPs is how sequence, structure and function are related. Phosphorylation, a type of post-translational modification prevalent in intrinsically disordered proteins and regions, is an example of how modifications at the sequence level

In this paper I argue against the traditional view that truth-making distributes over entailment and present a novel account that takes truth-making to distribute over grounding between the existence of facts, thus avoiding the shortcomings of the traditional view.In this paper I argue against the traditional view that truth-making distributes over entailment and present a novel account that takes truth-making to distribute over grounding between the existence of facts, thereby avoiding the shortcomings of the traditional view.