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Challenges for QCD theory: some personal reflections

At the LHC all processes are QCD ones, whether 'signal' or 'background'. In this review the frontiers of current QCD research are addressed, towards increased understanding, improved calculational precision, and role in potential future discoveries. Issues raised include: the limits of perturbative QCD calculations and parton distribution usage, the nature of multiparton interactions, the impact o

Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice

Probiotic bacteria provide unique opportunities to study the global responses and molecular mechanisms underlying the effects of gut-associated microorganisms in the human digestive tract. In this study, we show by comparative transcriptome analysis using DNA microarrays that the established probiotic Lactobacillus plantarum 299v specifically adapts its metabolic capacity in the human intestine fo

Time trends between 1987 and 2007 for perfluoroalkyl acids in plasma from Swedish women.

Perfluoroalkyl acids (PFAAs) are a large group of chemicals which are highly persistent in both nature and humans. The use of the most prominent ones, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), was reduced in the early 21st century, and since then levels in human matrices have decreased. However, these two compounds have been exchanged by other PFAAs, for which time trends

Biochar increases arbuscular mycorrhizal plant growth enhancement and ameliorates salinity stress

We examined combined effects of biochar, arbuscular mycorrhizal (AM) fungi and salinity on plant growth and physiology to test whether and how biochar influences AM fungi mediated growth and nutrition enhancements, and whether and how biochar provides amelioration in salt stressed soils. We carried out a full three-factorial greenhouse experiment with Lactuca sativa; and a second study with a wide

Postprandial Glycemia, Insulinemia, and Satiety Responses in Healthy Subjects after Whole Grain Rye Bread Made from Different Rye Varieties. 1

Rye products typically induce low insulin responses and appear to facilitate glucose regulation. The objective of this study was to investigate differences in postprandial glucose, insulin, and satiety responses between breads made from five rye varieties. Breads made from whole grain rye (Amilo, Rekrut, Dankowski Zlote, Nikita, and Haute Loire Pop) or a white wheat bread (WWB) were tested in a ra

Challenges of tourism in a low-carbon economy.

This article reviews the interrelationships of tourism and climate change from a mitigation perspective. Tourism is an increasingly important part of the global economy that is dependent on the annual movement of billions of travelers, often over large distances. The current contribution of the tourism sector to global climate change is reliably established at approximately 5% of CO2 emissions, th

Economic optimization design of shell-and-tube heat exchangers by a cuckoo-search-algorithm

This paper presents an optimization of shell and tube heat exchangers with respect to the total annual costs by a cuckoo search algorithm. The total annual cost is considered as the optimization objective so as to obtain economic heat exchanger structures. The performance of the CSA algorithm is further compared with various algorithm representative of the state of the art in heat exchanger optimi

A Homoleptic Trisbidentate Ru(II) Complex of a Novel Bidentate Biheteroaromatic Ligand Based on Quinoline and Pyrazole Groups: Structural, Electrochemical, Photophysical, and Computational Characterization.

We synthesized a new homoleptic, tris-bidentate complex [Ru(QPzH)3](2+) based on the novel biheteroaromatic, 8-(3-pyrazolyl)-quinoline ligand QPzH. The QPzH ligand was designed to reduce the distortions typically observed in complexes incorporating the 8-quinolinyl group into the ligand framework. This was indeed observed, and was also, as anticipated, found to facilitate the formation of tris-hom

Adsorption mechanisms of glucose in aqueous goethite suspensions

The adsorption of glucose and polysaccharides onto solid surfaces is important in several areas of science and engineering including soil chemistry and mineral processing. In this work we have studied the adsorption of D-glucose at the water-goethite (alpha-FeOOH) interface as a function of pH using batch adsorption measurements and a simultaneous infrared and potentiometric technique. Molecular o

Mammography and Osteoporosis Screening-Clinical Risk Factors and Their Association With Digital X-Ray Radiogrammetry Bone Mineral Density.

The aim of this study was to study the association between digital X-ray radiogrammetry (DXR) T-score and clinical risk factors for osteoporosis. Women were recruited 2 d per wk at a single mammography screening center between year 2010 and 2012. Included women answered a questionnaire about risk factors for osteoporosis, and a radiograph of the nondominant hand was obtained for DXR analysis. Univ

Strain fields and mechanical response of a high to medium fissured bentonite clay

This article presents the developments of an ongoing research aimed at modelling the influence of fissuring on the behaviour of clays. In particular, it recalls the main results of an extensive laboratory investigation on a fissured bentonite clay from the south of Italy and presents the data of a new investigation on the evolution with shearing of the strain fields developing within the clay, res

Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: Studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus

Objective To assess the efficacy of paquinimod, a new immunomodulatory small molecule, in a murine lupus model, and to evaluate its pharmacokinetics and tolerability in systemic lupus erythematosus (SLE) patients at doses predicted to be efficacious and safe and determine the maximum tolerated dose. Methods The efficacy of paquinimod was studied in lupus-prone MRL-lpr/lpr mice and compared with th

Comparing five different iterative reconstruction algorithms for computed tomography in an ROC study

The purpose of this study was to evaluate lesion conspicuity achieved with five different iterative reconstruction techniques from four CT vendors at three different dose levels. Comparisons were made of iterative algorithm and filtered back projection (FBP) among and within systems. An anthropomorphic liver phantom was examined with four CT systems, each from a different vendor. CTDIvol levels of

Development of an efficient statistical volumes of fluid-Lagrangian particle tracking coupling method

The breakup of a liquid jet into irregular liquid structures and droplets leading to the formation of a dilute spray has been simulated numerically. To overcome the shortcomings of certain numerical methods in specific flow regimes, a combined approach has been chosen. The intact liquid core, its primary breakup and the dense spray regime are simulated using the volumes of fluid (VOF) method in co

A niobium water target for routine production of [(18)F]Fluoride with a MC 17 cyclotron.

A [(18)F]Fluoride water target was constructed for a Scanditronix MC 17 cyclotron, without a beam line, with a typical wide beam of ∼30×5mm(2). Niobium was used as target chamber material. One hour irradiation with 45μA protons yields about 110GBq [(18)F]Fluoride. The saturation yield is 8.0±0.6GBq/μA (EOB). The FDG yield is 60±5% (EOS) with a TracerLab MX (G.E. Healthcare). More than 100GBq FDG i

Aspects of ‘physiognomic depiction’ in pictures : from macchia to microgenesis

“Figurativity”, roughly paraphrased as that which is not accounted for by the system, is a residue concept of both Piaget’s theory of cognitive development and of Greimasean semiotics. In the latter case, however, figurativity has been related to the second, so-called plastic layer of the picture, which is opposed to the pictorial layer, by means of which the picture is doing its job of depicting

Watching the dynamics of electrons and atoms at work in solar energy conversion

The photochemical reactions performed by transition metal complexes have been proposed as viable routes towards solar energy conversion and storage into other forms that can be conveniently used in our everyday applications. In order to develop efficient materials, it is necessary to identify, characterize and optimize the elementary steps of the entire process on the atomic scale. To this end, we

Pharmacokinetic digital phantoms for accuracy assessment of image-based dosimetry in (177)Lu-DOTATATE peptide receptor radionuclide therapy.

Patient-specific image-based dosimetry is considered to be a useful tool to limit toxicity associated with peptide receptor radionuclide therapy (PRRT). To facilitate the establishment and reliability of absorbed-dose response relationships, it is essential to assess the accuracy of dosimetry in clinically realistic scenarios. To this end, we developed pharmacokinetic digital phantoms correspondin