Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) are mature CD5(+) B-cell malignancies with different biological/clinical characteristics. We recently reported an association between different prognostic subgroups of CLL (i.e., IGHV mutated and unmutated) and genomic methylation pattern. However, the relationship between DNA methylation and prognostic markers, such as the prolifer

To be able to disseminate knowledge about maritime safety culture and safety management to different actors in the Swedish maritime sector, a didactic design was developed and evaluated. The didactic design includes an interactive scenario-based module and a teacher’s guide and is based on a model for experience-based learning that connects theory and practice by a cyclic approach. Students at up

We study the curvature of manifolds which admit a complex-valued submersive harmonic morphism with either, totally geodesic fibers or that is holomorphic with respect to a complex structure which is compatible with the second fundamental form. We also give a necessary curvature condition for the existence of complex-valued harmonic morphisms with totally geodesic fibers on Einstein manifolds.

This article uses social network data to study the integration of local elites in four Swedish municipalities. Four research questions are asked. First: How integrated are the elites? While the results modify the picture that there are two rather distinct elites in Sweden – that is, a political elite dominated by the labour movement and an economic elite dominated by business and the large busines

The Chrysididae are a group of cleptoparasitic and parasitoid aculeate wasps with a large number of rare and endangered species. The taxonomy of this group has long been confusing due to the similarity of species and extensive intraspecific variation. We present for the first time a comprehensive dichotomous key for all 74 species found in the Nordic and Baltic countries. In addition to diagnostic

In hybrid zones populations that are otherwise allopatric meet and produce hybrids. One of the most well-known hybrid zones occurs throughout much of Europe between the hooded and carrion crows. Even though these species (or subspecies) of crows look very different, genetic differentiation is weak, and introgression seems to be common. In a spatial simulation that was based on empirically estimate

Organic bulk heterojunction (BHJ) solar cells offer a viable source of solar energy. Structural organization is crucial in BHJ cells but hard to achieve and assess due to limitations in experimental methodology. Quantum chemical methods have here been used to gain further insight into the geometric and optical properties of a promising light-harvesting polymer, poly[2,3-bis(3-octyloxyphenyl)quinox

Pyrimidines are important nucleic acid precursors which are constantly synthesized, degraded, and rebuilt in the cell. Four degradation pathways, two of which are found in eukaryotes, have been described. One of them, the URC pathway, has been initially discovered in our laboratory in the yeast Lachancea kluyveri. Here, we present the global changes in gene expression in L. kluyveri in response to

In semiconductor heterostructures with a type II band alignment, such as GaSb-InAs, conduction can be tuned from electron- to hole-dominated using an electrostatic gate. However, traditional conductance measurements give no direct information on the carrier type, and thus limit the ability to distinguish transport effects originating from the two materials. Here, we employ thermovoltage measuremen

Are serum levels of micro-RNAs miR-155 and miR-146a associated with male fertility, low-grade systemic inflammation (LGSI) and androgens?

The electronic structure of superheavy elements (Z ≥ 104) and their chemical properties are dominated by relativistic effects. Recently two superheavy elements were recognized by the IUPAC and named flerovium (Fl, Z = 114) and livermorium (Lv, Z = 116). Fl is the heaviest element with which chemical experiments were performed. Here, we report on experiments that help answering the long-standing qu

The properties of dipolar cubic lattices are studied and the paradox of how to obtain a long range polarization in such lattices is resolved by choosing a proper shape of the total system. It has been shown that large but finite number of aligned dipoles prefer to exist as needle shaped macroscopic particles [M. Yoon and D. Tománek, J. Phys.: Condens. Matter 22, 455105 (2010)]. The total energy fo

Objective. We studied the prevalence and effect on disease activity of ever having had second-hand exposure to tobacco smoke in Swedish rheumatoid arthritis (RA) patients who had never smoked. Methods. Between 1992 and 2005, 2,800 patients were included in the BARFOT early-RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ),

Recently, natural d-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using d-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown.

The major input signals entering the PID controller are: the setpoint, the process output, and measurable load disturbances. By feeding these signals through suitable filters, the properties of the feedback loop can be improved significantly. The goal of this paper is to provide a unified discussion about these filters. The paper treats set-point handling, feedforward from load disturbances, TITO

We present results from the anodization of an aluminum single crystal [Al(111)] and an aluminum alloy [Al 6060] studied by in situ x-ray reflectivity, in situ electrochemical impedance spectroscopy and ex situ scanning electron microscopy. For both samples, a linear increase of oxide film thickness with increasing anodization voltage was found. However, the slope is much higher in the single cryst

Blood flow velocity patterns in fetal veins are considered to reflect cardiac function, but have not been convincingly documented. The aim of this study was to generate reference values for fetal cardiac strain and compare it with results in fetuses with signs of increased venous pulsatility.

Dodecyl glucooligosides, a class of interesting non ionic surfactant molecules were synthesized by cyclodextrin glucanotransferase from Bacillus macerans using either alpha-cyclodextrin (alpha-CD) or soluble starch as glycosyl donor and dodecyl beta-D-glucoside (C(12)G(1)) or dodecyl beta-D-maltoside (C(12)G(2)) as acceptor substrates. The primary coupling products obtained in the respective react

Quinoline-3-carboxamides are currently in clinical development for treatment of both autoimmune disease and cancer. Carboxamides such as ABR-215757 (5757) have shown efficacy in several in vivo mouse models of human inflammatory autoimmune disease. Some microbial infections in mice cause GM-CSF dependent accumulation of dendritic cells expressing TNFα and inducible nitric oxide synthase (iNOS; Tip