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Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mit
Journal of Thrombosis and Haemostasis Supplement 1(3):abstract 0802. DOI: 10.1111/j.1538-7836.2005.03001.x
J Thromb Haemostas 2009;7(Suppl2): abstract 721. DOI: 10.1111/j.1538-7836.2009.03473_2.x
The effects of the first lactational incidence of clinical mastitis (CM) on milk, fat, and protein production were studied in the Swedish Red and Swedish Holstein breeds. The data consisted of 38,535 weekly production records from 1,192 lactations (506 cows), sampled from 1987 to 2004 in one of the university's research herds. Daily yields were analyzed using a repeated-measures mixed model with a
Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR
Electron correlation and multielectron effects are fundamental interactions that govern many physical and chemical processes in atomic, molecular and solid state systems. The process of autoionization, induced by resonant excitation of electrons into discrete states present in the spectral continuum of atomic and molecular targets, is mediated by electron correlation. Here we investigate the attos
Resected hippocampal tissue from patients with drug-resistant epilepsy presents a unique possibility to test novel treatment strategies directly in target tissue. The post-resection time for testing and analysis however is normally limited. Acute tissue slices allow for electrophysiological recordings typically up to 12 hours. To enable longer time to test novel treatment strategies such as, e.g.,
In this study, electrospinning has been employed to produce micro to nano scale fibres of whey protein in order to investigate their potential for use in the food industry. Initially, spinning of pure whey protein proved challenging; so in order to facilitate the spinning of freshly prepared aqueous solutions, small amounts of polyethylene oxide (as low as 1% w/w in solution) were incorporated in
Advances in sequencing technologies led to rapid increase in the number and diversity of biological sequences, which facilitated development in the sequence research. In this paper, we present a new method for analyzing protein sequence similarity. We calculated the spectral radii of 20 amino acids (AAs) and put forward a novel 2-D graphical representation of protein sequences. To characterize pro
This article takes stock of the world's largest low-carbon technology demonstration programme – the EU's NER 300. The programme has been marked by delays and many withdrawn projects since becoming operational in 2010: CCS projects have failed and not reached final investment decisions; wind and solar projects have succeeded, whereas bioenergy projects have seen successes as well as failures. These
Denna avhandling syftar till att utöka kunskapsbasen om hur grundskolelärare i Sverige kommunicerar och interagerar i sitt yrke och vilka arbetsrelaterade hälsoproblem de upplever. Avhandlingen bygger på två studier, vilka genererat tre artiklar. Papper I är baserat på resultat från en explorativ studie med fokusgruppsmetodik. I denna studie undersöktes arbetsplatskommunikationspraxis bland skolläDuring recent years, schoolteachers in Sweden have experienced many reforms and societal changes, resulting in altered conditions for work. Subsequently, many teachers have reported an increased workload and reduced well-being. In addition, previous research has identified a need for more contextually anchored measures of demands and resources pertaining to teachers’ work situation.This dissertati
While health might deteriorate through the ageing and disablement process, the impacts of disability can be reduced by adapting the environment. This study aimed to investigate the effects of applying a standardized research-based strategy to housing adaptation as compared to ordinary practice with respect to falls and fear of falling. Another aim was to investigate the overall effects of housing
Purpose: An unprecedented scale of human migration has lead humanitarians to view camps as long-term settlements rather than temporary holding facilities. The purpose of this paper is to increase the understanding of and identify challenges with this proposed new approach to camp design. Design/methodology/approach: Based on the camp design literature, the authors developed an interview guide and
Two new genera in the subfamily Teloschistoideae (Teloschistaceae, Teloschistales) are described: Hosseusiella S. Y. Kondr., L. Lőkös et A. Thell for the Caloplaca chilensis group including three South American species and Rehmanniella S. Y. Kondr. et J.-S. Hur for the new species, R. wirthii S. Y. Kondr. from South Africa. The new genera are supported by a three-gene phylogeny based on ITS1/ITS2
Nineteen new to science species of lichen forming fungi, i.e.: Agonimia ascendens S. Y. Kondr., L. Lőkös et J.-S. Hur, A. sunchonensis S. Y. Kondr. et J.-S. Hur, A. yongsangensis S. Y. Kondr. et J.-S. Hur, Biatora loekoesiana S. Y. Kondr. et J.-S. Hur, Caloplaca ivanpisutii S. Y. Kond., L. Lőkös et J.-S. Hur, Candelariella makarevichiae S. Y. Kondr., L. Lőkös et J.-S. Hur, Huriella pohangensis S.
I detta kapitel diskuteras kritiskt två relaterade tendenser i filosofiska teorier om mänskliga rättigheter. Den första handlar om synen på rättighetsinnehavaren. Mänskliga rättigheter har kommit att betraktas som något som människor ”har” och då uppstår frågan vad det är med människor som gör dem till rättighetsinnehavare. Ett vanligt svar är att människor besitter den moraliska värdighet som gör
In the article I investigate the differences between Ansel Adams' and Jerry Uelsmann's use of nature in their respective photography. Through their attitudes, approaches to, and involvement with nature their different relations to the photographic medium and the creative process unfold. Uelsmann's departure from the straight photographic tradition - that Ansel Adams came to symbolize - is in the a
