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As the backbone of the extracellular matrix (ECM) and the perineuronal nets (PNNs), hyaluronic acid (HA) provides binding sites for proteoglycans and other ECM components. Although the pivotal of HA has been recognized in Alzheimer's disease (AD), few studies have addressed the relationship between AD pathology and HA synthases (HASs). Here, HASs in different regions of AD brains were screened in

There is increasing recognition of the potential pleiotropic effects of melanin pigmentation, particularly on immunity, with reports of variation in haemoparasite infection intensity and immune responses between the morphs of colour-polymorphic bird species. In a population of the black sparrowhawk (Accipiter melanoleucus) in western South Africa, light morphs have a higher haemoparasite infection

Bidirectional Low Temperature Networks (BLTNs) are an innovative technology of district heating and cooling systems. Because of their intrinsic feature of supplying simultaneous heating and cooling either directly from an energy source/sink or through distributed heat pumps and chillers, circulation pumps installed at each building extract water from the network and a distinct pressure cone is sub

Background and objective: The treatment landscape of metastatic prostate cancer (mPCa) has evolved significantly over the past two decades. Despite this, the optimal therapy for patients with mPCa has not been determined. This systematic review identifies available predictive models that assess mPCa patients’ response to treatment. Methods: We critically reviewed MEDLINE and CENTRAL in December 20

High-resolution object vision — the ability to separate, classify, and interact with specific objects in the environment against the visual background — has only been conclusively shown to have evolved in three of the thirty-five animal phyla: chordates, arthropods, and mollusks (cephalopods)1. However, alciopid polychaetes (Phyllodocidae, Alciopini), which possess a pair of bulbous camera-type ey

The current global food system is characterized by anonymity in the value chain, global food trade, loss of knowledge about food sources, and a distant producer-consumer relationship. In addition, the negative environmental impacts of the agricultural sector, such as pollution, degradation of soil and water quality, loss of biodiversity, and significant greenhouse gas emissions, make this sector a

The Impostor Profile scale (IPP30) is a recently developed tool designed to delve into the nuanced aspects of the Impostor Phenomenon (IP), a psychological phenomenon where individuals wrongly attribute their successes to external factors, discounting their own abilities and often feeling like frauds. This study aimed to assess the psychometric properties, including factor structure, internal cons

Earlier this year, authorities in the Xinjiang Uyghur Autonomous Region passed a revised version of the Xinjiang Regulations on Religious Affairs. The new rules emphasize the Sinicization of religion, ensuring that sites of religious worship, like mosques, reflect “Chinese characteristics and style.” Moreover, they are calling for the cultivation of “patriotic” religious leaders. Despite enshrinin

This study investigates the application of machine learning, specifically Fourier neural operator (FNO) and convolutional neural network (CNN), to learn time-advancement operators for parametric partial differential equations (PDEs). Our focus is on extending existing operator learning methods to handle additional inputs representing PDE parameters. The goal is to create a unified learning approac

Importance: Accurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions. Objective: To develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach. Design, Se

A commonly held assumption is that demonstration and pantomime differ from ordinary action in that the movements are slowed down and exaggerated to be better understood by intended receivers. This claim has, however, been based on meagre empirical support. This article provides direct evidence that the different functional demands of demonstration and pantomime result in motion characteristics tha

This article focuses on the rapidly growing Swedish market of app-based audio erotic fiction through an analysis of two significant apps and publishers: Blanche Stories and Ava Stories. We explore audio erotica apps as devices of both literature, pleasure and intimate sonic connectivity. First, we discuss the specific affordances of the born-audio format, its flexible and mobile forms of listening

Kataegis is a hypermutation phenomenon characterized by localized clusters of single base pair substitution (SBS) reported in multiple cancer types. Despite a high frequency in breast cancer, large-scale analyses of kataegis patterns and associations with clinicopathological and molecular variables in established breast cancer subgroups are lacking. Therefore, WGS profiled primary breast cancers (

The location of the Congo-São Francisco (CSF) craton, one of the largest cratons in Proterozoic paleogeography, has been poorly constrained for the supercontinent Nuna interval (ca. 1800–1300 Ma). Initial models of Nuna suggested that the CSF craton was part of the Atlantica continent, together with Amazonia, West Africa, and perhaps Río de la Plata, as a separate continental block from other Nuna

Backround: We wanted to characterize conditional survival in prostate cancer (PC) in Sweden around and after 2005 when the vast increase in incidence due to the opportunistic testing for prostate specific antigen (PSA) culminated. We hypothesize that analyzing survival data during that time period may help interpret survival trends. We focus on stage-specific analysis using conditional survival in

Biopharmaceuticals are complex biological molecules that require careful storage and handling to ensure medication integrity. In this study, a work system analysis of real-world protein drug (PD) handling was performed with the following goals: identify main barriers and facilitators for successful adherence to accepted recommendations in PD handling, analyse differences in two organizations, and

The joint expression of particular colors, morphologies, and behaviors is a common feature of adaptation, but the genetic basis for such “phenotypic syndromes” remains poorly understood. Here, we identified a complex genetic architecture associated with a sexually selected syndrome in common wall lizards, by capitalizing on the adaptive introgression of coloration and morphology into a distantly r

People with intellectual disabilities commonly experience violent, abusive, and restrictive contexts, particularly those who are at risk of behaviours that challenge, behaviours that often are a sign of trauma, fear, pain, and loss of power. For example, the use of physical restraint and psychotropic medication to manage behaviours labelled as challenging is prevalent in services for people with i

We present a study of the evolution of cosmic filaments across redshift with an emphasis on some important properties: filament lengths, growth rates, and radial profiles of galaxy densities. Following an observation-driven approach, we built cosmic filament catalogues at z = 0, 1, 2, 3, and 4 from the galaxy distributions of the large hydro-dynamical run of the MilleniumTNG project. We employed t