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PURPOSE Most patients with early-stage breast cancer are treated with adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) to prevent locoregional recurrence (LRR). However, no genomic tools are used currently to select the optimal RT strategy. METHODS We profiled the transcriptome of primary tumors on a clinical grade assay from the SweBCG91-RT trial, in which patients with node-negat

Competence in performing Building Performance Simulations (BPS) is a fundamental asset for an energy specialist. However, teaching BPS to new students can be challenging, often due to the overwhelming capabilities of the software. The consequences for students are frustration and lack of confidence using the software, dividing group work based on previous expertise and, mostimportantly, the inabil

We investigate how the life satisfaction of migrants is affected by life satisfaction in their background country and in their new country of residence. In particular, we contribute to the literature by differentiating between first- and second-generation immigrants and by differentiating between types of background country. Using data from the European Social Survey on 30,000 immigrants from 200

In this study, the authors describe the meanings of experiences of being dependent on a ventilator (HMV) and living at home as narrated by 13 people who had been using a ventilator via a mask or tracheostomy for half a year. The analyses revealed various movements across time toward the goal of using the ventilator successfully, and some narratives depicted suffering caused by care. The analyses a

Aim. The aim of this paper is to illuminate meanings of becoming dependent on home mechanical ventilator treatment. Background. People suffering from chronic alveolar hypoventilation and requiring home mechanical ventilation represent a small but increasing group in society, and are some of the most vulnerable individuals with chronic disabilities. Method. Thirteen people about to begin ventilator

The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Least squares estimation (IDEAL) reconstruction was implemented on a clinical 3 T pos

Nine adults were interviewed in order to illuminate the meanings of being dependent on a ventilator and living at home. The data were analysed using a phenomenological-hermeneutic method inspired by the philosophy of Ricoeur. Five main themes emerged through the analysis: experiencing home as a safe and comfortable space from which to reach out, experiencing the body as being frail, brave and resi

Background: Familial breast cancer risk studies usually overlook the dynamic nature of family history. Methods: The authors assessed the effect of incorporating the timing of cancer diagnosis events into the assessment of familial risks of breast cancer in first-degree and second-degree relatives in a nationwide cohort study of 5,099,172 women (follow-up was between 1958-2015). Family history was

Introduction: Radiotherapy is an established treatment option for prostate cancer (PCa), both as primary treatment and secondary treatment after radical prostatectomy (RP). Since 1998, detailed data on radiotherapy delivered to Swedish men with PCa (e.g. treatment modalities, absorbed doses, fractionation) have been collated within PCa data Base Sweden (PCBaSe). This study reports patterns of radi

Much has been written about models, aims and the concept of clinical group supervisional, although few studies are empirical or focus on intensive care. • The aim of the study was to illuminate the process and describe, using qualitative content analysis, the content of conversations carried out during the course of clinical group supervision sessions among Registered Nurses (RN) and enrolled nurs

Objective: Novel, highly effective disease-modifying therapies have revolutionized multiple sclerosis (MS) care. However, evidence from large comparative studies on important safety outcomes, such as cancer, is still lacking. Methods: In this nationwide register-based cohort study, we linked data from the Swedish MS register to the Swedish Cancer Register and other national health care and census

With the aim of clarifying critical care nursing, six critical care nurses, working in a Swedish intensive care unit (ICU) were each asked to narrate a care situation with which they had been satisfied or dissatisfied. The stories were tape-recorded and analysed using a phenomenological-hermeneutic approach inspired by the philosophy of Ricoeur. The themes uncovered in the analysis describe the nu

Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully understood. Here, we investigated the pathogenesis of these changes and significance of maternal hypoglycaemia extending beyond organogenesis in non-diabe

Since the prescription of antibiotics in the hospital setting is often empiric, particularly in the critically ill, and therefore fraught with potential error, we analysed the use of antibiotic agents in Swedish intensive care units (ICUs). We examined indications for antibiotic treatment, agents and dosage prescribed among 393 patients admitted to 23 ICUs at 7 tertiary care centres, 11 secondary

The rise of populist parties and movements in general and right-wing populist parties in particular has been noted also in the public health literature. While economic and other factors behind the populist surge have been systematically analyzed in the political and social science literature, the understanding of this political phenomenon seems weak in important parts of the public health literatu

Based on the experiences of insufficient burnout in industrial fluidized bed furnaces despite adequate mixing and availability of oxidizer, the influence of potassium on CO and H2 oxidation in combustion environments was investigated. The combustion environments were provided by a laminar flame burner in a range relevant to industrial furnaces, i.e. 845 °C to 1275 °C and excess air ratios ranging

Industrial symbiosis (IS) is a key paradigm for achieving circular economy among industrial firms. Achieving new IS projects often requires outside facilitation, and intermediaries can help solidify and expand existing IS networks. While various intermediary roles have been identified in the literature, less attention has been paid to the potential challenges that intermediaries might encounter in

Peptidoglycan has been retained in chloroplasts that have evolved from cyanobacteria along some evolutionary tracks, but has seemingly been quickly eliminated during evolution of others. It has been eliminated in Rhodophyta, Chlorophyta, Pteridophyta and Spermatophyta, but has been retained in streptophyte algae, Glaukophyta, and Lycophyta. In this article questions emerging from this are raised,

H-infinity optimal control and estimation are addressed for a class of systems governed by partial differential equations with bounded input and output operators. Diffusion equations are an important example in this class. Explicit formulas for the optimal state feedback controller as well as the optimal state estimator are given. Unlike traditional methods for H-infinity synthesis, no iteration i

A material parameter identification is presented for a fully thermo-mechanically coupled material model based on full field displacement and temperature measurements. The basic theory of the inverse problem is recapitulated, focusing on the choice of the objective function, proposing a new formulation, and explaining in detail the necessary numerical treatment of experimental data during the pre-p