This thesis summarises two studies in which the main purpose was to find out how and why the amount of the protein histatin 5 that adsorbs to negatively charged surfaces changes with pH and ionic strength. Histatin 5 is an intrinsically disordered saliva protein, and in the oral environment it adsorbs to tooth enamel. The approach here is to simplify the biological system by using an aqueous buffe

För att skapa matematiska beskrivningar av fysiska fenomen inom bland annat naturvetenskap, teknik och medicin används ofta partiella differentialekvationer. Listan med tillämpningar kan göras hur lång som helst: sådana ekvationer kan beskriva hur en snöflinga bildas, hur strukturer deformeras när de utsätts för mekaniska krafter, hur partiklar interagerar på kvantnivå, hur blodet flödar i hjärnanSplitting methods are widely used temporal approximation schemes for parabolic partial differential equations (PDEs). These schemes may be very efficient when a problem can be naturally decomposed into multiple parts. In this thesis, splitting methods are analysed when applied to spatial splittings (partitions of the computational domain) and physical splittings (separations of physical processes)

AIM: To date, the understanding and development of novel treatments for mental illness is hampered by inadequate animal models. For instance, it is unclear to what extent commonly used behavioural tests in animals can inform us on the mental and affective aspects of schizophrenia.METHODS: To link pathophysiological processes in an animal model to clinical findings, we have here utilized the recent

Coexistence among unequal conspecific interferers should be unlikely to persist if stronger interferers always experience a relative fitness increment from their higher foraging rates. In this study, we suggest that decreased relative costs to weaker interferers with increasing temporal fluctuations in prey availability may be a mechanism enhancing coexistence of unequal conspecific interferers. P

BACKGROUND. High resolution spatial details of the distribution of activity in three dimensions is required to evaluate the localization and dosimetric properties of radiolabelled monoclonal antibodies in tumors and normal tissues. Planar imaging of small animals with a resolution of 5-10 mm is usually the imaging modality of choice. The authors investigated high resolution single-photon emission

Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder, caused by an expansion of a CTG triplet repeat in the DMPK gene. The aims of the present study were to classify a cohort of children with DM1, to describe their neuropsychiatric problems and cognitive level, to estimate the size of the CTG expansion, and to correlate the molecular findings with the neuropsychiatric problems. Fifty-

Our previous studies have indicated that the IgG-binding M-family proteins (IgGBP) of group A streptococci may be involved in eliciting experimental acute poststreptococcal glomerulonephritis (APSGN) in the rabbit. These surface proteins were also found to trigger production of anti-IgG, which might conceivably act to enhance renal deposition of immune complexes (IC). In the present study, a clini

Using three different laser systems, we demonstrate a convenient and simple plasma based diagnostic of the contrast of high-power short-pulse lasers. The technique is based on measuring the specular reflectivity from a solid target. The reflectivity remains high even at relativistic intensities above 10(19) W/cm(2) in the case of a high-contrast prepulse-free laser. On the contrary, the specular r

Popular Abstract in Swedish Detta arbete behandlar regleringen av arbetsgivarens arbetsledningsrätt och arbetstagarens arbetsskyldighet i svensk, engelsk och tysk rätt i ljuset av arbetslivets ökade flexibilisering. Arbetslivets flexibilisering handlar om att öka anpassningsförmågan och rörligheten, och beskrivs ofta som övergången från den traditionella anställningen till atypiska anställningar. The general aim of this doctoral thesis is to study the legal regulation of the managerial prerogative and how it relates to the employee’s obligation to work in Swedish, English and German law in the light of the increasing flexibilisation of working life. The ongoing flexibilisation of working life is often described as an increase in adaptability and allocative flexibility, and as a shift from

Background: Population-based prevalence studies suggest that psychosis is a continuum distributed in the general population. Aim: To assess the prevalence of delusional ideation in young healthy individuals in a low-income country setting (Uganda) and to investigate possible relevant background factors. Method: Interviews were conducted in a district capital and in three rural villages, using the

The former winter sports camp Frostavallen was connected by a track to the nearest railway halt, now part of the Skaneleden subtrail Ridge to Ridge. Rubus echinatus, R. senticosus and R. sciocharis occur at three sites in the area, probably a result of timber import half a century ago.

A population of 101 laboratory technicians handling laboratory animals was studied with regard to predisposing factors for allergy. Twenty-seven had symptoms indicating laboratory animal allergy (LAA); of these, nine had asthma and were skin prick test positive for animal allergens. The LAA asthmatics had an increased frequency of a family history of allergy (relative risk, RR = 3.8); the predicti

OBJECTIVES This study was designed to investigate the loss of well-being, in terms of lift-years, overall and in patients randomized to metoprolol versus carvedilol in the Carvcdilol Or Metoprolol European Trial (COMET). BACKGROUND The ultimate objectives of treating patients with heart failure are to relieve suffering and prolong life. Although the effect of treatment on mortality is usually desc

BACKGROUND: Calcitonin-related peptides have been found in the human prostate, and calcitonin (CT) and calcitonin gene-related peptide (CGRP) have been demonstrated in subpopulations of neuroendocrine (NE) cells. The purpose of this study was to determine the concentrations of CT and CGRP as well as the densities of NE cells in normal prostates, benign prostatic hyperplasia (BPH), and carcinoma of

Neural progenitors in the adult dentate gyrus continuously produce new functional granule cells. Here we used whole-cell patch-clamp recordings to explore whether a pathological environment influences synaptic properties of new granule cells labeled with a GFP-retroviral vector. Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave ri

Clonality studies of mature cells suggest that the primary transformation event in myelodysplastic syndrome (MDS) most frequently occurs in a myeloid-restricted progenitor, a hypothesis supported by recent studies of purified CD34(+)Thy1(+) hematopoietic stem cells (HSCs) in cases with trisomy 8 (+8). In contrast, we recently demonstrated that a lymphomyeloid HSC is the target for transformation i

in vitro models are often used to investigate pathophysiological mechanisms of brain cell injury as they occur for instance during cerebral ischemia. To analyze the efficacy of potential neuroprotective compounds, cell physiological experiments were performed in a recently improved culture system of human model neurons. The postmitotic neurons were generated from the human NT-2 teratocarcinoma cel