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Aggregation of the hyperphosphorylated tau protein is a central driver of Alzheimer’s disease, and its accumulation exhibits a rich spatiotemporal pattern that unfolds during the course of the disease, sequentially progressing through the brain across axonal connections. It is unclear how this spatiotemporal process is orchestrated, namely, to what extent the spread of pathologic tau is governed b
REM sleep behavior disorder (RBD), is a prodromal synucleinopathy affecting a subset of Parkinson’s disease (PD) patients and associated with neuropsychiatric symptoms. This study compared the genetic profiles of 13,020 PD patients with probable RBD (PD + RBD) and 5403 without (PD-RBD) using genome-wide association study (GWAS). RBD was assessed by questionnaires or self-reporting. Potential genet
Background: Socioeconomic status (SES) can influence health outcomes. Both SES and older age are associated with polypharmacy, health literacy, and quality of care. Understanding how SES influences healthcare experiences of older adults with polypharmacy can serve to inform future interventions aiming at optimising patient care. Therefore, we investigated the association between older patients’ SE
Aims: There is current apprehension among some clinicians and conflicting evidence regarding ocular complications in relation to Glucagon-like peptide-1 receptor agonists (GLP-1RAs). We aimed to generate multi-disciplinary, expert-led consensus recommendations relating to ocular complications to facilitate optimum prescribing of GLP-1RAs. Materials and Methods: A modified Delphi was conducted foll
Variation in the structure and size of the eye in relation to light environments is well-documented across animal taxa. However, the long-term effects of ultraviolet radiation (UVR) on eye size across generations remain understudied, despite natural fluctuations in UVR being common in aquatic habitats. Here, we used Daphnia magna to test whether an evolutionary history of UVR threat modifies plast
Key message: A candidate gene exhibiting pleiotropic effect on twelve different seed size and weight traits was identified through a combination of evidence from population genetic selection, GWAS, earlier QTL studies, transcriptome analysis, and transgenic analyses. Abstract: Peanut is an important oilseed crop. Seed weight and size significantly impact yield, leading to the identification of num
Scale loss is a quintessential hydrodynamic adaptation in marine reptiles, and paralleled the pelagic specializations of Mesozoic ichthyosaurs, plesiosaurs, and metriorhynchid crocodylians, as well as the modern Leatherback Sea turtle (Dermochelyidae). By contrast, modern hard-shelled sea turtles (Cheloniidae) retain both scutes and scaly flippers, despite evolving from among partially scale-less
To prepare students for addressing wicked problems such as climate change and inequality, higher education must foster systemic and interdisciplinary thinking. We developed a flexible, interactive workshop grounded in sustainability goals and transitions theory to promote abductive reasoning across disciplines. Using cases on food waste, fashion, and e-waste, the workshop was tested in four divers
In recent years, under the influence of climate change and human activities, droughts and floods have occurred frequently in the Yangtze River Basin (YRB), seriously threatening socioeconomic development and ecological security. The topography and climate of the YRB are complex, so it is crucial to develop appropriate drought and flood policies based on the drought and flood characteristics of dif
Aim Postural orthostatic tachycardia syndrome (POTS) is a disorder with cardiovascular autonomic dysfunction where multiple and variable symptoms are common, including those from the peripheral and enteric nervous systems. We aimed to investigate subjective and objective signs of small and large fiber neuropathy in a Swedish POTS cohort compared with healthy controls. Secondly, we wanted to examin
Historical lessons are useful or even necessary for our guidance and orientation in time. These lessons, however, have often been overlooked in historical reflections on watershed moments, such as genocides, treaties, and global movements. Focusing on how cataclysmic events, primarily within Central and Eastern Europe, have been transmitted across borders and generations, this volume interrogates
This paper studies the economic impacts of land ownership concentration among the aristocratic elite in the Russian Empire. I document that areas with a higher concentration of noble land ownership were associated with lower levels of primary education during 1880–1911. Exploring the mechanisms, I show that by controlling local governments the landed elites decreased public spending on education,
Purpose: Glioblastoma (GBM) in elderly patients has a poor prognosis. About one-third of patients have impaired perioperative performance status (PS) and often excluded from clinical trials. Brain biopsy is the standard diagnostic approach when resection is not feasible. Previous studies on preoperative prognostic factors have mostly focused on resected patients. This study aimed to identify preop
The chemical industry must undergo a dual transformation: electrifying energy use and defossilizing carbon feedstocks. This paper, developed by ENGIEs Scientific Council, examines how energy and chemistry can converge to enable this shift. We assess the roles of biomass, recycled plastics, and CO2 as sustainable carbon sources and explore the enabling potential of electrification, low-carbon hydro
Easy and low-threshold access is considered to be a major advantage of online services. In Sweden, social services in several municipalities strive to increase their accessibility by responding to anonymous users online. This paper raises the question about the nature of accessibility that the online social services entail. Two online platforms were studied: synchronous online chats and asynchrono
How is Turkish official memory negotiated locally in Izmir, a city celebrated as a symbol of national becoming, yet (im)famous for its scepticism of central power? How is the past of the city narrated, conceived as an epitome of progress, yet built on a systematic forgetting of trauma and violence? And how does the secularist legacy of Izmir, accentuated in contrast with the Islamisation of memory
On October 29 2023, Turkey celebrates the centenary of the Republic. We may anticipate this to be an equally spectacular and politicized event: a purported celebration of national unity, which in essence will reproduce and re-affirm distinct political wedges. Carefully choreographed national celebration has a long history in Turkey. And historiography has been its narrative bedrock, highlighting t
BACKGROUND AND OBJECTIVES: Addressing the association between early-changing Alzheimer disease (AD) biomarkers and cognition is essential for characterizing preclinical AD. However, few studies have explored this relationship longitudinally, especially across multiple biomarker modalities. The aim of this study was to evaluate longitudinal associations of multimodal core 1 AD biomarkers with cogni
The growing use of 5G networks for critical services makes them vulnerable to Distributed Denial of Service (DDoS) attacks. While numerous Machine Learning (ML)-based approaches have been proposed, the real-world deployability of these models remains understudied. This work presents what is, based on existing literature, the first simulation-driven methodology to evaluate both the transferability
