INTRODUCTION: More than 70 common alleles are known to be involved in breast cancer (BC) susceptibility, and several exhibit significant heterogeneity in their associations with different BC subtypes. Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associatio

BACKGROUND: Widespread pain is a common comorbidity in several chronic diseases and is suspected to be caused by the underlying disease that has provoked a state of central sensitization. However, this argument is currently limited by evidence that has not sufficiently captured the temporal nature of the relationship between diagnosis of the underlying disease and onset of widespread pain. The aim

A recent review by Lindskog & Young (2019) of a paper published in Lethaia by Bergström et al. (2018a) contains many errors, misleading statements and unsupported opinions. Their review claims that we did not consider biostratigraphy in our efforts to chemostratigraphically date the Winneshiek Shale. That this is incorrect is shown by the fact that Liu et al. (2017), which contains a two-page

Community currencies have emerged as a tool for building more inclusive local economic development and governance. Grassroots organisations in Nairobi and Mombasa (Kenya) have been experimenting with this form of local monies. Communities in informal settlements in Kisumu have shown interest in introducing their own community currency. Challenges remain concerning the best diffusion strategy of su

Although researchers across the social sciences speak of a linguistic turn, most research exploring culture still assumes a traditional perspective on language, which conceives meaning as representation. Yet, Wittgenstein convincingly criticized the epistemological basis of such a perspective, offering an alternative view on language. The paper begins by explaining the central points of a performa

This report summarizes the activities of the NLM working group of the Workshop 'Physics at TeV Colliders', Les Houches, France, 11-29 June, 2007.

In the 19th and early 20th centuries there were numerous non-proprietors paupers in the Swedish countryside such as crofters, boarders and inhabitants of rural slums. With a change in the heritage legislation, increased possibilities to archaeologically investigate the non-proprietors of the recent past have emerged, but the archaeological material is still both scarce and of a repetitive characteIn the 19th and early 20th centuries there were numerous non proprietor, poor and pauper people in the Swedish countryside such as crofters, boarders and inhabitants of rural slums. With a change in the heritage legislation, increased possibilities to archaeologically investigate the non proprietors of the recent past has emerged, however the archaeological material is still both scarce and of a r

There are several different approaches used to treat prostate cancer, depending on age and general health conditions of the patient but also how severe the cancer is. To determine the latter, Gleason grading is used. The grade is determined by a pathologist, based on structures in histology samples from prostate biopsies. To determine the diagnosis, both the most common Gleason grade but also the

WISC-III (Wechsler, 1991) index score profiles and their characteristics were examined with traditional statistics in a large Swedish sample consisting of children with autistic disorder (n = 85), Asperger's disorder (n = 341), or pervasive developmental disorders not otherwise specified (PDD-NOS; n = 94). There was a clear and significant difference in level between children with Asperger's disor

The orbit and physical parameters of the previously unsolved double-lined eclipsing binary Tyc 5227-1023-1, discovered during the search for RR Lyr variable candidate members of the Aquarius stream, are derived using high-resolution chelle spectroscopy and V, i' photometry. A synthetic spectral analysis of both components has been performed, yielding metallicity [M/H] =-0.63± 0.11 for both stars a

Accurate and precise radius estimates of transiting exoplanets are critical for understanding their compositions and formation mechanisms. To know the planet, we must know the host star in as much detail as possible. We present first results from the K2-HERMES project, which uses the HERMES multi-object spectrograph on the Anglo-Australian Telescope to obtain R ∼ 28000 spectra of up to 360 stars i

The ability to determine the myelin water fraction (MWF) in vivo is essential to assessments of neurodevelopmental myelination and myelin damage in neurodegenerative diseases. The analysis of multi-exponential T2 decay data relies on the non-negative-least-squares (NNLS) fitting, which may be sensitive to the chosen fitting parameters. We performed simulations to explore the outcomes of NNLS under

We used satellite remote sensing data; fractionof photosynthetically active radiation absorbed by vegetation(fPAR) from the Moderate Resolution Imaging Spectrora-diometer (MODIS) in combination with tower eddy covari-ance and meteorological measurements to characterise theLight Use Efficiency parameter (ε)variability and the maxi-mumε(εmax)for two contrasting Canadian peatlands. Eight-day MODISfPA

Lymphocytes are the key cells of the adaptive immune system that provide antigen-specific responses tailored to the context of antigen exposure. Through cytokine release and antibody production, lymphocytes orchestrate and amplify the recruitment and function of other immune cells and contribute to host defense against invading pathogens and the pathogenesis of many inflammatory diseases. Lymphocy

Microbial attachment to mucosal surfaces is a first step in mucosal infection. Specific interactions between microbial surface ligands and host receptors influence the distribution of microbes in their sites of infection. Adhesion has often been regarded as a sufficient end point, explaining tissue tropism and bacterial persistence at mucosal sites. Adherence, however, is also a virulence factor t

Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemo

This study analysed the effects of immunoregulatory cytokines on uroepithelial cell cytokine responses. The A-498 human kidney cell line was treated with the interleukins IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, interferon gamma (IFN-α) and transforming growth factor beta (TGF-β1). Secreted IL-6 and IL-8 were quantitated by enzyme-linked immunoabsorbent assay (ELISA) and bioassay; IL-6 and IL-8 mRNA

Localized at the border between the external environment and the internal tissue, epithelial cells are exposed to stimulants from two directions. Microorganisms in the lumen can activate the transcription of cytokine mRNA and cytokine secretion, and cytokines in the mucosal environment can modify endogenous and microbially induced epithelial cytokine responses. Epithelial cells thus actively parti