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Role of novel tumor suppressors in colon cancer : Mechanisms and therapeutic opportunities
Colon cancer is the third most common cancer in the world and the fourth most common cause of cancer related deaths. Inflammation is one of the risk factors for development of colon cancer. Interestingly immune cells as mast cells and inflammatory mediators as LTC4 play an important role in colon cancer. Genetic predisposition, which might lead to either activation of oncogenes or inhibition of tu
Wake analysis of aerodynamic components for the glide envelope of a jackdaw (Corvus monedula)
Gliding flight is a relatively inexpensive mode of flight used by many larger bird species, where potential energy is used to cover the cost of aerodynamic drag. Birds have great flexibility in their flight configuration, allowing them to control their flight speed and glide angle. However, relatively little is known about how this flexibility affects aerodynamic drag. We measured the wake of a ja
Mid-Holocene humid periods reconstructed from calcite varves of the Lake Woserin sediment record (north-eastern Germany)
Time-series of varve properties and geochemistry were established from varved sediments of Lake Woserin (north-eastern Germany) covering the recent period AD 2010–1923 and the mid-Holocene time-window 6400–4950 varve years before present (vyr BP) using microfacies analyses, x-ray fluorescence (µ-XRF) scanning, microscopic varve chronology, and 14C dating. The microscopic varve chronology was compa
Kinetic and thermodynamic study of the interactions between human carbonic anhydrase variants and polystyrene nanoparticles of different size
The activity and adsorption of three variants of human carbonic anhydrase (HCA) with similar topology but variation in charge and stability were studied in the presence of carboxyl-modified polystyrene nanoparticles of different sizes ranging from 25 nm to 114 nm. The balance of forces driving the adsorption of carbonic anhydrase variants is affected by the physicochemical properties of the protei
Integrated Transceivers for Millimeter Wave and Cellular Communication
Abstract:This doctoral thesis is addresses two topics in integrated circuit design: multiband direct conversion cellular receivers for cellular frequencies and beam steering transmitters for millimeter wave communication for the cellular backhaul. The trend towards cellular terminals supporting ever more different frequency bands has resulted in complex radio frontends with a large number of RF in
Early onset of industrial-era warming across the oceans and continents
The evolution of industrial-era warming across the continents and oceans provides a context for future climate change and is important for determining climate sensitivity and the processes that control regional warming. Here we use post-ad 1500 palaeoclimate records to show that sustained industrial-era warming of the tropical oceans first developed during the mid-nineteenth century and was nearly
Microsphere-based modeling of electro-active polymers
Elektroaktiva polymerers (EAPs) främsta egenskap är deras förmåga att kunna omvandla elektrisk energi till mekanisk energi (och vice versa). Den typ av EAPs som behandlas inom ramen för detta arbete kallas för dielektriska elastomerer och är en undergrupp av elektroniska elektroaktiva polymerer. De karakteriseras av en väldigt låg elastisk styvhet, kapabel till stora elastiska deformationer, och a
Colour in the eye of the beholder : receptor sensitivities and neural circuits underlying colour opponency and colour perception
Colour vision — the ability to discriminate spectral differences irrespective of variations in intensity — has two basic requirements: (1) photoreceptors with different spectral sensitivities, and (2) neural comparison of signals from these photoreceptors. Major progress has been made understanding the evolution of the basic stages of colour vision–opsin pigments, screening pigments, and the first
Web Based Supportive Intervention for Families Living with Schizophrenia – An Open Trial
European Tax Integration: Law, Policy and Politics : Smaller Countries vs Bigger Countries: How can their voices and goals being harmoniously reconciled
Increased Permeability of the Aquaporin SoPIP2;1 by Mercury and Mutations in Loop A
Aquaporins (AQPs) also referred to as Major intrinsic proteins, regulate permeability of biological membranes for water and other uncharged small polar molecules. Plants encode more AQPs than other organisms and just one of the four AQP subfamilies in Arabidopsis thaliana, the water specific plasma membrane intrinsic proteins (PIPs), has 13 isoforms, the same number as the total AQPs encoded by th
Another way to think about psychological change : experiential vs. incremental
The traditional pre-post treatment difference reflects an incremental notion of change, where a quantity of some psychological function is added to (or subtracted from) a pretreatment quantity. This study presents a complementary, experiential notion of change. Rather than a difference, change is a feeling or experience of having changed, a feeling that one is different than before. Based on a pos
Screening of infants at eight months for atypical development in primary health care in southern Sweden
Screening studies of a population in primary health care are sparsely reported. The aim was to describe observed atypical behaviours that may be associated with autism spectrum conditions, in a population (n = 4329) of infants at eight months. Observations were performed by paediatric nurses. An observational instrument, named SEEK developed for child health care, was used focusing on social inter
Review of current study methods for VRU safety. Appendix 6 – Scoping review: surrogate measures of safety in site-based road traffic observations : Deliverable 2.1 – part 4.
Aesthetic Regulations of Objectionable Representations: A Semiotic Approach to Memorials and Materialised Religious Thought.
In acts of memorialisation, the objects that ”help” people get into contact with (their memory of) the deceased – like gravestones, personal collections of the deceased’s paraphernalia, objects placed at sites of sudden death, etc. – are often strictly regulated, differently in different cultures. At ”wrong” spots in the urban environment for instance, memorial places can thus be regarded as highl
Crystal growth, structure, magnetic properties and theoretical exchange interaction calculations of Cu2MnBO5
Single crystals of ludwigite Cu2MnBO5 were synthesized by flux growth technique. The detailed structural and magnetic characterizations of the synthesized samples have been carried out. The cations composition of the studied crystal was determined using X-ray diffraction and EXAFS technique, the resulting composition differ from the content of the initial Mn2O3–CuO components of the flux. Magnetic
Predictions of temperature and pressure fields due to collapse of a bubble in sulfuric acid solution under ultrasound
A gas bubble under the influence of an ultrasonic field so strong to destroy any material due to high pressures and temperatures reached during the collapse is the topic of the present paper. In the current work, simulations have been performed to describe the radial dynamics of a gas (argon) bubble being strongly forced to periodic oscillation in a highly viscous liquid like aqueous sulfuric acid