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We have recently discovered that the ZZ zinc finger domain represents a novel small ubiquitin-like modifier (SUMO) binding motif. In this study we identify the binding epitopes in the ZZ domain of CBP (CREB-binding protein) and SUMO1 using NMR spectroscopy. The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO interaction

The aim of this report is to present a technical detail of use in the management of an anorectal malformation (ARM). A boy with ARM and a fistula to the urethra was operated on with a posterior sagittal anorectoplasty (PSARP). Before the PSARP operation, a videoendoscopy was performed through the distal stoma down to the distal end of the rectum. The rectourethral fistula was identified and a guid

Acoustophoresis is a technique that applies ultrasonic standing wave forces in a microchannel to sort cells depending on their physical properties in relation to the surrounding media. Cell handling and separation for research and clinical applications aims to efficiently separate specific cell populations. Here, we investigated the sorting of CD8 lymphocytes from peripheral blood progenitor cell

Biomass burning impacts vegetation dynamics, biogeochemical cycling, atmospheric chemistry, and climate, with sometimes deleterious socio-economic impacts. Under future climate projections it is often expected that the risk of wildfires will increase. Our ability to predict the magnitude and geographic pattern of future fire impacts rests on our ability to model fire regimes, using either well-fou

The widespread growth of reefs formed by a framework of biogenic constructors and frame-lacking carbonate mounds began on Baltica during Ordovician time. Previously, Ordovician reef and mound development on Baltica was considered to be sporadic and local. A review of all known bioherm localities across the Baltic Basin reveals a more consistent pattern. Ordovician bioherms grew in a wide E–W-align

We demonstrate a new screening method for obtaining a prostate-specific antigen (PSA) binding aptamer based on an acoustofluidic separation (acoustophoreis) technique. Since acoustophoresis provides simultaneous washing and separation in a continuous flow mode, we efficiently obtained a PSA binding aptamer that shows high affinity without any additional washing step, which is necessary in other sc

Based upon the results of repeated psychologic tests, psychic impairment following myelography has been studied in 60 patients. Thirty of these had lumbar myelography with metrizamide and 30 with iohexol. Psychic impairment was noted in both groups, although with a higher frequency and much more marked in the group which had metrizamide myelography. For this type of examination iohexol is thus to

Melanocortin therapy by using adrenocorticotropic hormone (ACTH) or non-steroidogenic melanocortin peptides attenuates proteinuria and glomerular injury in experimental glomerular diseases and induces remission of nephrotic syndrome in patients with diverse glomerulopathies, even those resistant to steroids. The underlying mechanism remains elusive, but the role of melanocortin 1 receptor (MC1R) h

The benefits of kHz lidar in ecological entomology are explained. Results from kHz-measurements on insects, carried out with a CW-lidar system, employing the Scheimpflug principle to obtain range resolution, are presented. A method to extract insect events and analyze the large amount of lidar data is also described.

The possibility of using psychologic tests to demonstrate psychic changes following myelography with metrizamide was investigated in 15 patients. The tests were made before and after the examination. The results revealed psychic changes of cognitive nature to occur both at 6 and at 24 hours after myelography. Of the tests used determination of the reaction time gave most significant results. Subje