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Endogenous polyamines modulate Ca2+ channel activity in guinea-pig intestinal smooth muscle

The polyamines spermine and spermidine inhibit L-type Ca2+ channels in whole-cell recordings from guinea-pig ileum cells (Gomez and Hellstrand, Pflugers Arch, 430:501-507, 1995 [4]). To study whether they modulate channel activity under physiological conditions, we further investigated their actions on Ca2+ channels and the effects of altered cellular polyamine contents. In inside-out patches, spe

Kuf, forskare och nazist

A short text on Herman Wirth, an esoteric nazi, with the focus on his period in Sweden 1948-53 (which builds on my own research)

Recombinant FVIIa in the treatment of warfarin bleeding

Patients receiving oral anticoagulant treatment have abnormally low levels of functional vitamin K-dependent coagulation proteins and consequently a clear risk of hemorrhagic complications. The incidence of hemorrhages has been reported to be around 0.6-0.7% per month at a therapeutic International Normalized Ratio (INR) and the incidence of major hemorrhagic events is substantial. Therefore, the

Supersensitivity to methacholine in rat urethra following hypertrophy or disuse

It has been possible to sensitize the rat urethra without cutting its nerves. This was achieved by hypertrophy or disuse. Hypertrophy of the urethra (2-4-fold weight increase) was caused by the presence of an intraluminal paraffin bolus. Disuse was caused by diverting the flow of urine from the lower urinary tract. When examined in vitro after an experimental period of 1 to 4 weeks the EC50 value

Review of Religion and Friendly Fire

This is a review (5 pages) of D.Z. Phillips' book "Religion and Friendly Fire. Examining Assumptions in Contemporary Philosohpy of Religion", Aldershot: Ashgate, 2004, written by request from Ars Disputandi.

Guds långa näsa och blödande hjärta. Gränser för Guds makt i Gamla testamentet

This article deals with the limits of divine power in the Old Testament. The aim is to show how one of the traditional attributes from ancient philosophical metaphysics, namely, omnipotence, does not fit the depiction of YHWH in the Hebrew Bible. The biblical traditions know of several limitations of divine power that must be reconciled to regional and functional limits, and the one must difficult

Introduction

Abstract in Undetermined This volume contains essays by five British philosophers and one Swedish philosopher working in metaphysics and in particular metaphysics as it relates to the philosophy of science. These philosophers are the core of a tight network of European philosophers of science and metaphysicians and their essays have evolved as a result of workshops in Lund, Edinburgh, and Athens.

Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy.

To compare ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) concentrations in umbilical cord blood of neonates who develop Sarnat stage II-III hypoxic-ischemic encephalopathy (HIE) to healthy controls, and to relate the concentrations to the severity of neurology and long-time outcomes.

Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactions.

We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sciatic nerve. Six or 12 weeks later, new nerve structures surrounded by a perineur

Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for Idiopathic Scoliosis.

Idiopathic Scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies (GWAS) have identified a number of common genetic variants that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to

Trends in blood pressure control in patients with type 2 diabetes - Data from the Swedish National Diabetes Register (NDR).

We assessed blood pressure (BP) trends in patients with type 2 diabetes from a national diabetes register using three cross-sectional samples (aged 30-85 years) in 2005, 2007 and 2009, and in patients from 2005 followed individually until 2009. The prevalence of hypertension was 87% among all 180 369 patients in 2009, although lower in subgroups with ages 30-39, 40-49 and 50-59 years: 40%, 60% and