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Building, characterising and catalytic activity testing of Co-C-protected amino acid complexes covalently grafted onto chloropropylated silica gel

Co-C-protected amino acid (C-protected L-histidine, L-tyrosine, L-cysteine and L-cystine) complexes were covalently grafted onto chloropropylated silica gel, and the materials thus obtained were structurally characterised by mid/far IR and X-ray absorption spectroscopies. The superoxide dismutase-like activities of the substances were determined via the Beauchamp-Fridovich test reaction. It was fo

Relative rate study of the kinetic isotope effect in the (CH3D)-C-13 + Cl reaction

The (CH3D)-C-13/(CH4)-C-12 kinetic isotope effect, alpha((CH3D)-C-13), of CH4 + Cl is determined for the first time, using the relative rate technique and Fourier transform infrared (FTIR) spectroscopy. alpha((CH3D)-C-13) is found to be 1.60 +/- 0.04. In addition, a quantum chemistry/transition state theory model with tunneling correction is constructed and the primary cause for alpha((CH3D)-C-13)

Lipid-Based Passivation in Nanofluidics

Stretching DNA in nanochannels is a useful tool for direct, visual studies of genomic DNA at the single molecule level. To facilitate the study of the interaction of linear DNA with proteins in nanochannels, we have implemented a highly effective passivation scheme based on lipid bilayers. We demonstrate virtually complete long-term passivation of nanochannel surfaces to a range of relevant reagen

Comparative Analysis of Safety Performance Indicators Based on Inductive Loop Detector Data

Conflicts in traffic stream have been detected by different safety performance indicators. This study aims to empirically investigate the differences between different indicators in detecting rear-end conflicts and assessing the risk in an uninterrupted flow. Micro-level data of a 24-hr traffic stream (including 6,657 vehicles) were captured using inductive loop detectors installed on a rural free

Endosperm and whole grain rye breads are characterized by low post-prandial insulin response and a beneficial blood glucose profile

Background: Rye products have previously been shown to induce comparatively low post-prandial insulin responses; irrespectively of their glycaemic indices (GI). However, the mechanism behind this lowered insulin demand remains unknown. An improved insulin economy might contribute to the benefits seen in epidemiological studies with whole grain diets on metabolic risk factors and weight regulation.

How to Uncover the Covert Saccade During the Head Impulse Test.

OBJECTIVE: The appearance of "covert" saccades in the head impulse test in patients with vestibular loss may lead to diagnostic misinterpretations. Here, we demonstrate a procedure that can convert covert eye saccades to overt when performing the head impulse test. PATIENTS: Patients with known vestibular deficits that have covert saccades during head impulse test. INTERVENTION: Diagnostic: random

Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B

Streptococcus pyogenes is the causative agent in a wide range of diseases in humans. Thrombin-activatable fibrinolysis inhibitor (TAFI) binds to collagen-like proteins ScIA and ScIB at the surface of S. pyogenes. Activation of TAFI at this surface redirects inflammation from a transient to chronic state by modulation of the kallikrein/kinin system. We investigated TAFI binding characteristics to S

Later Medieval Aristocratic Landscapes in Scandinavia

During the last couple of decades it has become obvious that the aristocracy created elite landscapes around their castles. The purpose of this paper is to discuss the presence of late medieval elite aristocratic landscapes in Scandinavia. The castles of Bergkvara in medieval Sweden and Glimmingehus and Gurre in medieval Denmark are discussed. The result shows that the Scandinavian aristocracy use

Environmental proxies of antigen exposure explain variation in immune investment better than indices of pace of life

Investment in immune defences is predicted to covary with a variety of ecologically and evolutionarily relevant axes, with pace of life and environmental antigen exposure being two examples. These axes may themselves covary directly or inversely, and such relationships can lead to conflicting predictions regarding immune investment. If pace of life shapes immune investment then, following life his

A single bisphosphonate infusion does not accelerate fracture healing in high tibial osteotomies.

Background Bisphosphonates increase the callus size and strength in animal fracture studies. In a human non-randomized pilot study of high tibial osteotomies in knee osteoarthritis, using the hemicallotasis (HCO) technique, bisphosphonates shortened the healing time by 12 days. In the present randomized study, we wanted to determine whether a single infusion of zoledronic acid reduces the time to

Automatic Intrinsic Calibration of Double-sided Silicon Strip Detectors

Abstract A reliable and simple-to-use algorithm was developed for the energy-calibration of double-sided silicon strip detectors (DSSSDs). It works by enforcing mutual consistency of p-side and n-side information for every detected event. The procedure does not rely on a dedicated data set for calibration and is robust enough to work fully automated without human supervision. The method was develo

Development of a survey instrument to investigate the primary care factors related to differences in cancer diagnosis between international jurisdictions

Background: Survival rates following a diagnosis of cancer vary between countries. The International Cancer Benchmarking Partnership (ICBP), a collaboration between six countries with primary care led health services, was set up in 2009 to investigate the causes of these differences. Module 3 of this collaboration hypothesised that an association exists between the readiness of primary care physic

The origin of the Brunflo fossil meteorite and extraterrestrial chromite in mid-Ordovician limestone from the Garde quarry (Jamtland, central Sweden)

The Brunflo fossil meteorite was found in the 1950s in mid-Ordovician marine limestone in the Garde quarry in Jamtland. It originates from strata that are about 5 million years younger than similar limestone that more recently has yielded >50 fossil meteorites in the Thorsberg quarry at Kinnekulle, 600 km to the south. Based primarily on the low TiO2 content (about 1.8 wt%) of its relict chromite

Chimpanzee (Pan troglodytes) and orangutan (Pongo abelii) forethought: self-control and pre-experience in the face of future tool use.

Planning for future needs has traditionally been considered to be restricted to human cognition. Although recent studies on great ape and corvid cognition challenge this belief, the phylogenesis of human planning remains largely unknown. The complex skill for future planning has not yet been satisfactorily established in any other extant primate species than our own. In humans, planning for future

Transport and interaction blockade of cold bosonic atoms in a triple-well potential

We theoretically investigate the transport properties of cold bosonic atoms in a quasi-one-dimensional (1D) triple-well potential that consists of two large outer wells, which act as microscopic source and drain reservoirs, and a small inner well, which represents a quantum-dot-like scattering region. Bias and gate 'voltages' introduce a time-dependent tilt of the triple-well configuration, and ar

Cellular mechanisms of taxane therapy in castration resistant prostate cancer

Chemotherapy of castration resistant prostate cancer (CRPC) is based on taxane formulations worldwide. Only 30-50 % of patients respond to this therapy and the exact cellular mechanisms of taxane resistance in PC cells are not fully elucidated. There is convincing evidence that androgen receptor (AR) is affected by exposure to these compounds. The studies presented in this doctoral thesis identify