Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a "functional ortholog" of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, whic

The purpose of this article is to explore the intersections between genes, the body and the lived experience of a genetic disease. This article is based on empirical material from a study on how individuals affected by Huntington’s disease experience their everyday life. This study identified two themes that represent and capture the experience of the affected individuals. The themes are (1) notic

Recension av Svante Nordin, Hitlers München.

Artikeln handlar om vad den nu lagfästa proportionalitetsprincipen i den nya förvaltningslagen innebär. I artikeln beskrivs mot bakgrund av tidigare forskning hur principen, med ursprung i tysk förvaltningsrätt, har fått insteg i svensk lagstiftning och utvecklats genom praxis, delvis med hjälp av europarätten. Vidare undersöks i vilken mån den nya regleringen uppfyller lagstiftningens syfte att f

The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon activation of immune receptors, including TNFR1 1 . Deficiency in the LUBAC components SHARPIN or HOIP in mice results in severe inflammation in adulthood or embryonic lethality, respectively, owing to deregulation of TNFR1-mediated cell death 2-8 . In humans, deficiency in

For a probability measure with compact and non-polar support in the complex plane we relate dynamical properties of the associated sequence of orthogonal polynomials {P n } to properties of the support. More precisely we relate the Julia set of P n to the outer boundary of the support, the filled Julia set to the polynomial convex hull K of the support, and the Green’s function associated with P n

The purpose of this paper is to discuss decorated stone tablets with coats of arms and memorial texts found on castle walls. The example considered here is Glimmingehus in Scania, in southern Sweden, erected in the late 15th century. Tablets with texts, coat of arms and ornaments are to be found both outside and inside the castle. The messages on the tablets can be said to promote a world of an el

OBJECTIVE: To study the relationship between two commonly used verbal memory tests in presurgical evaluation for temporal lobe epilepsy (TLE) in Sweden, the Claeson-Dahl Test for verbal learning and retention (CDT) and the Swedish version of the Rey Auditory Verbal Learning Test (RAVLT).METHODS: Fifty-nine patients with TLE (male: 41%, mean: age 41.7 ± 12.3 years; epilepsy onset at mean age: 18.3

OBJECTIVES: To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS).METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of t

Aim: To investigate self-reported needs for care, support and treatment among persons who frequently visit psychiatric emergency rooms (PERs).Design: A cross-sectional design. Qualitative and quantitative data were collected using an interview-based manual. Qualitative data were analysed using content analysis, whereas quantitative data were analysed using descriptive, non-parametric statistical t

A large literature emphasizes that elite capture of political institutions hampered the spread of mass schooling in the nineteenth and twentieth century. We collect new data on investments in elementary education and the distribution of voting rights for more than 2,000 local governments in nineteenth‐century Sweden and document that educational expenditure was higher where the distribution of pol

The development of functionally competent, self-tolerant T cells in the thymus is an essential prerequisite for the formation of adaptive immune responses against foreign pathogens. Thymic epithelial cells (TECs) form specialized stromal microenvironments in the cortex (cTEC) and medulla (mTEC) of the thymus that support all stages of T cell development, from the entry of thymocyte progenitors to

I studier av resenärernas, och potentiella resenärers, preferenser är den geografiska skalan en intressant parameter: lokalt, regionalt, interregionalt. Det finns emellertid ingen tydlig bild av gränsdragningarna däremellan. Ett antal möjliga definitioner har identifierats i litteraturen, men dessa definitioner är tämligen vaga och använder dessutom olika typer av indikatorer. I syfte att reda ut When exploring preferences of existing and potential public transport passengers, it isrelevant to acknowledge differences between different geographic scales: local, regionaland interregional. However, the boundaries between these categories remain unclear.Some previous attempts have been made to define regional travel – and hence local andinterregional travel – but the resulting definitions are

Interdisciplinary research within the field of sustainability studies often faces incompatible ontological assumptions deriving from natural and social sciences. The importance of this fact is often underrated and sometimes leads to the wrong strategies. We distinguish between two broad approaches in interdisciplinarity: unificationism and pluralism. Unificationism seeks unification and perceives Interdisciplinary research within the field of sustainability studies often faces incompatible ontological assumptions deriving from natural and social sciences. The importance of this fact is often underrated and sometimes leads to the wrong strategies. We distinguish between two broad approaches in interdisciplinarity: unificationism and pluralism. Unificationism seeks unification and perceives

The main issue in the epistemology of peer disagreement is whether known disagreement among those who are in symmetrical epistemic positions undermines the rationality of their maintaining their respective views. Douven and Kelp have argued convincingly that this problem is best understood as being about how to respond to peer disagreement repeatedly over time, and that this diachronic issue can b