In this study we report on reactive Large Eddy Simulations (LES) of flow and combustion in the US Air Force Research Laboratory Research Cell 19 cavity-based scramjet combustor. This case involves combustion of ethylene that is injected into a cavity. It has previously been studied experimentally with multiple techniques as well as numerically using hybrid RANS/LES. Here, we build on the existing

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, with ~40–50% of patients diagnosed with non-metastatic disease (stages IA–IIIC). The treatment landscape is evolving rapidly as immunotherapies and targeted therapy are introduced in the non-metastatic setting, creating a need to assess patient outcomes prior to their introduction. This real-world study usin

In past human populations, atherosclerosis has been identified in mummies from different regions of the world, and from a range of chronological periods (for extensive reviews see Chapters 3 and 4). This current study from Sweden aims to contribute to the limited evidence for atherosclerosis associated with human skeletal remains by presenting examples of atherosclerosis in another part of the bod

In this paper, a factor-augmented version of the New Keynesian Phillips curve (NKPC) is assessed using a data set comprised of a large panel of European Union (EU) member countries. The factor-augmentation is natural given that country-level inflation rates are highly co-moving. The presence of unattended common factors is important because it raises the issue of omitted variables bias, as the rea

Addressing the need for modulated spin configurations is crucial, as they serve as the foundational building blocks for next-generation spintronics, particularly in atomically thin structures and at room temperature. In this work, we realize intrinsic ferromagnetism in monolayer flakes and tunable ferro-/antiferromagnetism in (Fe0.56Co0.44)5GeTe2 antiferromagnets. Remarkably, the ferromagnetic ord

Objective. Non-neuronal acetylcholine (ACh) has been suggested to be a mediator for the development of various types of cancer. We analyzed a possible role for this molecule in carcinogenesis and/or progression of human colon cancer, in patient biopsies harvested from the colon during surgery. We addressed whether ACh synthesis (by choline acetyltransferase) and/or degradation (by ACh esterase), a

We used immunochemistry to demonstrate expression of acetylcholine's nicotinic α7-receptor subtype in human colon cancer cell line HT-29. Moreover, RT-PCR and immunochemistry showed that choline acetyltransferase and acetylcholine esterase, the enzymes responsible for acetylcholine synthesis and degradation, respectively, localise in HT-29 cells. Bromoacetylcholine bromide, an inhibitor of choline

Glycogen is a hyperbranched glucose polymer, serving as a major energy reservoir in animals. Characterization of the size distributions of complex branched polysaccharides helps in the understanding of their structural and functional properties. This study compared the effectiveness of various techniques in analyzing glycogen size distributions, namely size-separation-based techniques (size exclus

Most definitions of cancer broadly conform to the current NCI definition: "Cancer is a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body." These definitions tend to describe what cancer "looks like" or "does" but do not describe what cancer "is" or "has become." While reflecting past insights, current definitions have not kept pace with the underst

How firms cope with tail risk is an under-researched problem in the literature on corporate risk management. This paper presents stylized facts on the nature of revenue shocks based on 65 years worth of Compustat data. We define a Black Swan as an unexpected year-on-year drop in revenue between 30%–90%. The rate of Black Swans has increased markedly since the 1970's and there are more pronounced c

The size and ‘quality’ of the population are issues of major concern in contemporary East Asia, as fertility rates are falling and competitiveness increasingly centers on ‘a fitting’ human capital. While Singapore is located in Southeast Asia geographically speaking, it is culturally linked to East Asia in terms of its heritage of Confucianism and the Chinese language. Singapore and other East AsiThe size and ‘quality’ of the population are issues of major concern in contemporary East Asia, as fertility rates are falling and competitiveness increasingly centers on ‘a fitting’ human capital. While Singapore is located in Southeast Asia geographically speaking, it is culturally linked to East Asia in terms of its heritage of Confucianism and the Chinese language. Singapore and other East Asi

This paper aims to initiate a discussion on the meanings and manifestations of child-centered relatedness, with a particular focus on parents’ educational care work and how parents navigate sentiments of uncertainty and risk in relation to their children’s future. By drawing on examples from ethnographic fieldwork in East Asia, I hope to contribute to expanding the lens on the moral and emotional

Femtoscopic correlations of nonidentical charged kaons (K+K-) are studied in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision sNN=2.76 TeV by ALICE at the CERN Large Hadron Collider. One-dimensional K+K- correlation functions are analyzed in three centrality classes and eight intervals of particle-pair transverse momentum. The Lednický and Luboshitz interaction model used

Hur går det till när besluts fattas om huruvida, när och vart ett barn eller en ungdom ska placeras i samhällsvård och vad händer med detta beslutsfattande när ärendetrycket ökar på organisationen? Den brittiske barnavårdsforskaren Nigel Parton (1998), bland andra, har hävdat att när trycket ökar och resurser blir färre inom människobehandlande organisationer som Socialtjänsten, är en vanlig reakt

BackgroundVentral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of Parkinson’s Disease (PD). However, one main challenge in the quality control of the cells is that rostral and caudal VM progenitors are extremely similar tr

Generating functional and perfusable micro-vascular networks is an important goal for the fabrication of large and three-dimensional tissues. Up to now, the fabrication of micro-vascular networks is a complicated multitask involving several different factors such as time consuming, cells survival, micro-diameter vasculature and strict alignment. Here, we propose a technique combining multi-materia

At the onset of the pandemic, Brazil’s Federal government approved an emergency basic income to be transferred to a variety of groups that had not earlier received any of the established welfare programs. Its implementation was however riddled with challenges. With a large informal economy, many Brazilian citizens were missing from the Federal Government’s registry and, even if registered, many di

Objectives: A starch- and sucrose-reduced diet has been found to improve gastrointestinal and extraintestinal symptoms in irritable bowel syndrome, as well as reduce weight and improve psychological well-being. Our hypothesis was that a starch- and sucrose-reduced diet would also be beneficial in other conditions with similar symptoms. The aim of the present research letter was to describe the rol