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The sentinel node concept in early cervical cancer performs well in tumors smaller than 2 cm.
OBJECTIVE: The aim of the study was to evaluate the sentinel node (SLN) concept for lymphatic mapping in early stage cervical cancer. METHODS: 105 women with early stage (1a1-2a) cervical cancer were scheduled for the sentinel node procedure in conjunction with a complete pelvic lymphadenectomy. The day before surgery, 1-1.5 mL 120MBq Tc(99) albumin nanocolloid was injected submucosally at four po
Synthesis and biology of oligoethylene glycol linked naphthoxylosides.
Proteoglycans (PGs) are important macromolecules in mammalian cells, consisting of a core protein substituted with carbohydrate chains, known as glycosaminoglycans (GAGs). Simple xylosides carrying hydrophobic aglycons can enter cells and act as primers for GAG chain synthesis, independent of the core protein. Previously it has been shown that aromatic aglycons can be separated from the sugar resi
Family environment and the malleability of cognitive ability: A Swedish national home-reared and adopted-away cosibling control study.
Cognitive ability strongly aggregates in families, and prior twin and adoption studies have suggested that this is the result of both genetic and environmental factors. In this study, we used a powerful design-home-reared and adopted-away cosibling controls-to investigate the role of the rearing environment in cognitive ability. We identified, from a complete national Swedish sample of male-male s
Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets
Environmental factors interact with the genome throughout life to determine gene expression and, consequently, tissue function and disease risk. One such factor that is known to play an important role in determining long-term metabolic health is diet during critical periods of development. Epigenetic regulation of gene expression has been implicated in mediating these programming effects of early
Development of core competencies for a new master of pharmacy degree
A Biophysical Model of Electrical Activity in Human β-Cells.
Electrical activity in pancreatic β-cells plays a pivotal role in glucose-stimulated insulin secretion by coupling metabolism to calcium-triggered exocytosis. Mathematical models based on rodent data have helped in understanding the mechanisms underlying the electrophysiological patterns observed in laboratory animals. However, human β-cells differ in several aspects, and in particular in their el
Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences.
Predicting any future metastatic site of early-stage breast cancer is important as it significantly influences the prognosis of advanced disease. This study aimed at investigating the potential of claudin-2, over-expressed in breast cancer liver metastases, as a biomarker for predicting liver metastatic propensity in primary breast cancer.
Chapter 12: Evidence-based skills and practices for the future of pharmacy
Characterizing the Astrometric Errors in the Gaia Catalogue
Accurate characterization of the errors in the global astrometric solution for Gaia is essential for making optimal use of the catalogue data. We investigate the structure of the covariance between the estimated astrometric parameters by studying the properties of the astrometric least squares solution. We find that astrometric errors can be separated in a star and an attitude part, due to the est
Perceptions of the worker role among people with psychiatric disabilities: Description and investigation of associated factors.
Objective: To investigate how subjective perceptions of everyday occupations, activity level, day centre attendance, social interaction, self-mastery and clinical factors were related to how unemployed people with psychiatric disabilities (PD) envision a future worker role, also controlling for socio-demographic variables. Participants: 175 people with PD; 93 attended a day centre and 82 did not.
Wahhabi ideology of social control versus a new publicness in Saudi Arabia
"Is There a Claim to Deserved Punishment?"
Geospatial tools address emerging issues in spatial ecology: a review and commentary on the Special Issue
Spatial ecology focuses on the role of space and time in ecological processes and events from a local to a global scale and is particularly relevant in developing environmental policy and (mandated) monitoring goals. In other words, spatial ecology is where geography and ecology intersect, and high-quality geospatial data and analysis tools are required to address emerging issues in spatial ecolog
The Pernicious Effects of Contaminated Data in Risk Management
Banks hold capital to guard against unexpected surges in losses and long freezes in financial markets. The minimum level of capital is set by banking regulators as a function of the banks’ own estimates of their risk exposures. As a result, a great challenge for both banks and regulators is to validate internal risk models. We show that a large fraction of US and international banks uses contamina
'How to Fight Savage Tribes': The Global War on Terror in Historical Perspective
Chemical composition, antioxidant capacity and content of phenolic compounds in meals collected in hospitals in Bolivia and Sweden
The objective of this study was to evaluate the proximal composition, as well as Total Antioxidant Capacity (TAC) and Total Phenols (TPH) in meals that represent a complex food matrix, from different hospitals in Bolivia and Sweden. Protein, fat, ash, dietary fiber and carbohydrate contents were measured in 29 samples: 20 from two Bolivian hospitals and 9 from the university hospital in Lund, Swed
Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer
Background: The role of estrogen and progesterone in the development of endometrial cancer is well documented. Few studies have examined the association of genetic variants in sex hormone-related genes with endometrial cancer risk. Methods: We conducted a case-control study nested within three cohorts to examine the association of endometrial cancer risk with polymorphisms in hormone-related genes
Association of muscarinic M(3) receptors and Kir6.1 with caveolae in human detrusor muscle.
Caveolae are 50-100nm large membrane invaginations that play a role in cellular signaling. The aim of the present study was to assess whether muscarinic M(3) receptors and the K(ATP) channel subunit Kir6.1 are associated with human detrusor caveolae, and to pharmacologically assess the relevance of this organization for contractility. Detrusor strips were dissected and used in ultrastructural, bio
Risk of pediatric celiac disease according to HLA haplotype and country.
The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against tissue transglutaminase (tTG).