Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals

Diachronic studies in Construction Grammar have received increasing attention in the past decade. Notable larger publications include an edited volume (Bergs & Diewald, eds. 2008), a special issue of Cognitive Linguistics (Hoffmann & Trousdale, eds. 2011) and two book-length treatments (Hilpert 2013, Traugott & Trousdale 2013). Now Diachronic Construction Grammar, edited by Barðdal, Sm

The enactment of the revised Payment Services Directive (PSD2) by the European Union, has pushed banks to develop digital open banking platforms to enhance market competition and promote innovation in the banking industry. PSD2 mandates banks to offer APIs to provide access to banking data to external third-party providers (TPPs). This mandate might disrupt the role of banks since external complem

In this paper I propose an emancipation effect that may follow from the ‘reducing effect’ of frequency (Bybee 2006): if a reduced realization of an item gains in frequency, it will become conceptually independent from the full form. In a context of grammaticalization, I show that this is the case for the form gonna, which is becoming emancipated from its source form going to. I use corpus data of In this paper I propose an emancipation effect that may follow from the ‘reducing effect’ of frequency (Bybee 2006): if a reduced realization of an item gains in frequency, it will become conceptually independent from the full form. In a context of grammaticalization, I show that this is the case for the form gonna, which is becoming emancipated from its source form going to. I use corpus data of

When looking at language historically, one Ànds that many words are derived from more complex constructions. For instance, in English, never used to be ›not ever‹ (Old English ne æfre), and maybe means ›it may be that‹; a rather bizarre case is ampersand (the name of the character ›&‹), which apparently is derived from ›and per se and‹. In today’s English, we accept these words as fully legitiOn-Going Change in English Modality: Emancipation Through Frequency The English modal expressions BE going to, HAVE got to, and want to are often contracted to gonna, gotta, and wanna in spoken language. These contracted forms have gained both in frequency and conventionality in recent times.In this article, I present an investigation into the status of the contractions between phonetic reduction

Advanced Parkinson's disease (PD) is characterized by motor fluctuations including unpredictable oscillations remarkably impairing quality of life. Effective management and development of novel therapies for these response fluctuations largely depend on clinical rating instruments such as the widely-used PD home diary, which are associated with biases and errors. Recent advancements in digital hea

Climate policies are often assumed to have significant impacts on the nature and speed of energy transitions. To investigate this hypothesis, we develop an approach to categorise, trace, and compare energy transitions across countries and time periods. We apply this approach to analyse electricity transitions in the G7 and the EU between 1960 and 2022, specifically examining whether and how climat

Place branding is defined as “the development of brands for geographic locationswith the aim of triggering positive associations about the area and distinguishinga place from other places” (Stevens et al., 2020, p. 752). Like all occupations,place branding is organised by discourses, or talk, that determine best practices andnorms about what constitutes expertise (Loacker and Sullivan, 2016). Expl

Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children within 12 months prior to the appearance of type 1 diabetes-linked islet autoantibodies

Climate warming increases carbon assimilation by plant growth and also accelerates permafrost CO2 emissions; however, the overall ecosystem CO2 balance in permafrost regions and its economic impacts remain largely unknown. Here we synthesize in situ measurements of net ecosystem CO2 exchange to assess current and future carbon budgets across the northern permafrost regions using the random forest

The UPCA for the first time establishes harmonized exceptions and limitations to the effects of granted patent rights. Previously these were the sole province of national law but a with a degree of similarity.This chapter briefly analyses the historical origin, legal nature and scope of Article 27 UPCA, the future harmonizing effect of UPCA patent limitations, followed by a discussion on each limi