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Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

Background About 30% of cases of chronic lymphocytic leukaemia (CLL) carry quasi-identical B-cell receptor immunoglobulins and can be assigned to distinct stereotyped subsets. Although preliminary evidence suggests that B-cell receptor immunoglobulin stereotypy is relevant from a clinical viewpoint, this aspect has never been explored in a systematic manner or in a cohort of adequate size that wou

Wage penalty of abstinence and wage premium of drinking-A misclassification bias due to pooling of drinking groups?

Several studies have found protective effects of low/moderate (hereafter 'light') alcohol consumption compared with 'abstinence' on mortality, health and wage. Some of these studies have been criticised because former drinkers have been included among the abstainers, which may overstate the protective effect of light alcohol consumption. It has also been proposed, but not shown, that the commonly

Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases

Background: The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases. Methods: In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-b

Epigenetic and Phenotypic Profiling of Urothelial Carcinoma

Popular Abstract in Swedish Epigenetik handlar om hur avläsning av informationen i arvsmassan kan styras och nedärvas mellan cellgenerationer. Förmågan att kunna ändra genuttrycksmönster som svar på signaler från omgivningen och sedan bibehålla dessa genom efterföljande celldelningar ligger till grund för korrekt funktion av vävnaderna och organen som våra kroppar är uppbyggda av. Samtliga sjukdomPrecise spatial and temporal regulation of gene expression programs is a prerequisite for multicellular life. Since the discovery of DNA as the carrier of genetic information, a key question in biology has been how these hard coded instructions are read and regulated to maintain cellular and organismal homeostasis. Understanding the mechanisms and processes governing gene and genome regulation are

Tissue Ingrowth Into Foam but Not Into Gauze During Negative Pressure Wound Therapy

Background. Foam and gauze are two types of wound fillers used for negative pressure wound therapy (NPWT). Differences in the wound healing effects of foam and gauze have been observed clinically. The aim of the present study was to examine the effects of NPWT on the wound bed using foam and gauze. Methods. A porcine peripheral wound model was treated with NPWT at 0, -75 mmHg, or -125 mmHg for 72

fUML Activity Diagrams with RAG-controlled Rewriting: A RACR Solution of The TTC 2015 Model Execution Case

This paper summarises a RACR solution of The TTC 2015 Model Execution Case. RACR is a metacompiler library for Scheme. Its most distinguished feature is the seamless combination of reference attribute grammars and graph rewriting combined with incremental evaluation semantics. The presented solution sketches how these integrated analyses and rewriting facilities are used to transform fUML Activity

Late Holocene and modern glacier changes in the marginal zone of Solheimajokull, South Iceland

The forefield of the Solheimajokull outlet glacier, South Iceland, has a variety of glacial landforms and sediments that are products of late Holocene and modern glacier oscillations. Several sets of moraine ridges reflect past ice front positions and river-cut sedimentary sections provide information about past environments. Here, we describe sediments and landforms deposited during the late Holo

Nationell adoption - ett alternativ till långvariga familjehemsplaceringar?

Utgångspunkten för detta examensarbete har varit de utsatta och behövande barn vars föräldrar av någon anledning inte kan eller vill ta hand om dem. Den primära frågan har varit vilka möjligheter dessa barn har till ett tryggt och fungerade liv och om de alternativ som finns idag är tillräckliga. Nationell adoption infördes i Sverige i början på 1900-talet och användes relativt frekvent under de The primary basis of this dissertation is the vulnerable children of parents unable or unwilling to care for them. The crucial question has been what possibilities these children have to live safe and functioning lives and whether the options provided today are sufficient. National adoption was made possible in Sweden in the early 20th century and was frequently used during the first 40 years to

Exploring the Cultural Trauma Theory

This is a study of the murder of the Swedish Prime Minister Olof Palme, not as it actually occurred, but rather how it was mediated through representations in the media. The guiding research question is formulated as follows: Can the media representations of the murder of Olof Palme be understood as a case of an emergent trauma process? These representations covers only the first week after the mu

Evaluation of scoring index with different normalization and distance measure with correspondence analysis

The purpose of this thesis is to analyze data for a scoring system and evaluate different normalization procedures and distance measures for correspondence analysis. When bootstrapping 100 samples and evaluating coordinates for the row and column profiles the results show that the representation of the coordinates for the row and column profiles are similar when looking at the normalizations metho

Ett öppet fönster : en studie av lokalsamhällets betydelse för biblioteksverksamheten

The aim with this Master’s thesis is to analyze how small scale libraries works to relate to, and meditate with, the local community. By studying four different public libraries we have gained knowledge in which different ways todays public libraries communicate with their surrounded community. By the process of interviews with local politicians, librarians and heads of libraries we have managed t

Mobila applikationer som reklam

Abstract Title: Consumer perception of mobile marketing Institution: Department of Service Management, Campus Helsingborg, Lund University Level: Master’s degree Authors: David Zetterlund and Jonas Lörnell Supervisors: Jessica Enevold and Katja Lindqvist Issue: Mobile marketing is the fastest growing category of advertising right now. Mobile marketing allows direct-targeted advertising to users an

Ekonomisk tillväxt som väg till demokratisering? - En kvalitativ studie om sambandet mellan ekonomisk tillväxt och demokratisering i fyra afrikanska länder

Inom demokratiforskningen finns det en mängd teorier om vilka faktorer det är som inom ett land initierar en demokratiseringsprocess. En av dessa teorier är moderniseringsteorin som pekar på det positiva sambandet mellan ekonomisk tillväxt och demokratisering. Syftet med studien är att utreda huruvida detta positiva samband mellan ekonomisk tillväxt och demokratisering existerar, samt att utreda v