Antithyroid treatment effectively restores euthyroidism in patients with Graves' hyperthyroidism. After a few months of treatment, patients are clinically euthyroid with normal levels of thyroid hormones, but in many patients TSH levels remain suppressed. We postulated that TSH receptor autoantibodies could directly suppress TSH secretion, independently from thyroid hormone levels, via binding to

Catheter-related deep venous thrombosis is a complication that can occur in patients receiving chemotherapy. Three such cases are described and a review of the literature is made, focusing on recent results regarding possible thrombogenic mechanisms and the high prevalence of non-symptomatic thrombosis as well as the high morbidity and mortality associated with upper extremity deep venous thrombos

A survey of transfusion-dependent thalassaemia was conducted to study epidemiology, treatment and follow-up routines as a basis for future discussions. Questionnaires were sent to 97 clinics in Sweden. Responses were submitted by 86 of the clinics, 21 of which cared for 32 patients (18 children, 14 adults; i.e.only one or a few patients per hospital). Ten of those 32 (33 procent) patients were bor

Violaxanthin deepoxidase (VDE) has been purified from spinach (Spinacia oleracea) leaves. The purification included differential sonication of thylakoid membranes, differential (NH4)2SO4 fractionation, gel filtration chromatography and finally either hydrophobic interaction chromatography or anion exchange chromatography. A total purification of more than 5000-fold compared to the original thylako

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. A

Proliferation, differentiation, and survival of hematopoietic cells are regulated by cytokines, acting through specific receptors. FLT3 ligand (FL) is one of the most important cytokines for regulation of the hematopoietic system, and its receptor FLT3 is expressed on both stem cells and progenitors. Regulation of Forkhead transcription factors has been described as an important mechanism to contr

We give approximation and online algorithms as well as data structures for some well studied problems in computational geometry. The thesis is divided into three parts. In part one, we study problems related to guarding, exploring and searching geometric environments. We show inapproximability results for guarding lines and 2-link polygons, question stated time bounds for computing shortest watch

Chemical control of desert locust (DL) is carried out over large areas of land, covering a range of different landscapes and ecosystems. There are no real restrictions for spraying in or close to environmentally sensitive areas and awareness of sensitivity is not always obvious to the people involved in control. However, concern about environmental issues in connection with DL control is growing a

The diffractive photoproduction of J/psi mesons is measured with the HI detector at the ep collider HERA using an integrated luminosity of 78 pb(-1). The differential cross section dsigma(gammap --> J/psiY)/dt is studied in the range 2 < < 30 GeV2, where t is the square of the four-momentum transferred at the proton vertex. The cross section is also presented as a function of the photon-proton cen

The calcination kinetics of limestone was investigated by TGA at 600-1000-degrees-C and from 1 mbar to 1 atm. The temperature, total pressure, CO2 partial pressure and particle size affect the calcination rate. Above 90% of calcination efficiency can be reached in less than 2.5 s at 1000-degrees-C and 1 mbar. Under the conditions of eliminating all diffusion resistances, the instantaneous rate of

In order to evaluate the potential of cardiovascular tissue characterisation using near-infrared (NIR) spectroscopy, spectra in a previously unexplored wavelength region 0.8-2.3 mu m were recorded from various pig heart tissue samples in vitro: normal myocardium (with and without endo/epicardium), aorta; fatty and fibrous heart tissue. The spectra were analysed with principal component analysis (P

2D and 3D models of a superconducting undulator suitable for the ESRF storage ring have been developed. The models are based on the performance of superconducting NbTi wire available from the cabling industry. Iron is used in the poles to enhance the peak field. The 2D model shows that it is possible to obtain a peak field of 1.18 T, corresponding to a K-value of 1.65, for a period length of 15 mm

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Dramatiska händelser har inträffat regelbundet under jordens historia. Primära, kortvariga katastrofer som t ex asteroidnedslag, omfattande vulkanism eller kraftiga jordskalv kan ge långvariga miljöeffekter, som t ex global uppvärmning eller nedkylning, förändringar i havsnivå och cirkulationsmönster, syrefria oceanbottnar mm. Alla deGeological and biological catastrophic events have occurred repeatedly in the Earth's history, leaving traces in the global stratigraphical record in the form of sedimentary features, geochemical anomalies and biotic turnovers. This thesis focuses on the sedimentological and geochemical signatures of several key events in the Phanerozoic stratigraphical record, and aims to interpret the different

This study aimed to investigate the presence of pain, pain duration, localization(s), intensity, type and pharmacological treatment among older adults living in sheltered accommodation or receiving rehabilitation, as well as the agreement between pain assessments performed by staff and the older adults. Twenty-nine randomly selected older adults (65+ years) and the staff who looked after them part