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Desiccation of the Sahara since the middle Holocene has eradicated all but a few natural archives recording its transition from a "green Sahara" to the present hyperarid desert. Our continuous 6000- year paleoenvironmental reconstruction from northern Chad shows progressive drying of the regional terrestrial ecosystem in response to weakening insolation forcing of the African monsoon and abrupt hy
Background: The yeast Saccharomyces cerevisiae provides unique opportunities to study roles and regulation of aqua/glyceroporins using frontline tools of genetics and genomics as well as molecular cell and systems biology. Scope of review: S. cerevisiae has two similar orthodox aquaporins. Based on phenotypes mediated by gene deletion or overexpression as well as on their expression pattern, the y
Recordings of the acoustic activity of free-swimming groups of echolocating dolphins increase the likelihood of collecting overlapping click trains, originating from multiple individuals, in the same set of data. In order to evaluate the click properties of each individual based on such recordings it is necessary to identify which clicks originate from which animal. This paper suggests a computati
In this paper, we review our efforts to use quantum mechanical (QM) methods to improve free-energy estimates of the binding of drug candidates to their receptor proteins. First, we have tested the influence of various implicit solvation models on predictions of the ligand-binding affinity. The accuracy of implicit solvation models strongly depend on the parameterisation, but also on the magnitude
The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of root s = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb(-1). The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b
Despite our fine-grain anatomical knowledge of the cerebellar cortex, electrophysiological studies of circuit information processing over the last fifty years have been hampered by the difficulty of reliably assigning signals to identified cell types. We approached this problem by assessing the spontaneous activity signatures of identified cerebellar cortical neurones. A range of statistics descri
We have developed a technique so that both transmission electron microscopy and microphotoluminescence can be performed on the same semiconductor nanowire over a large range of optical power, thus allowing us to directly correlate structural and optical properties of rotationally twinned zinc blende InP nanowires. We have constructed the energy band diagram of the resulting multiquantum well heter
This study was designed to investigate attitudes to and incentive for reporting adverse drug reactions (ADRs) in general and towards nurses as reporters of ADRs in particular in a sample of hospital physicians. A questionnaire was sent to 1,201 randomly selected hospital physicians. The main factors for the decision to report an ADR were the severity of the reaction, a reaction to a new drug, and
This study investigated mental workload in basic civil aviation training. Heart rate, eye movement, and subjective ratings from 11 students were collected during simulator and aircraft sessions. Results show high correspondence in psychophysiological reactions between the sessions. For some flight segments, heart rate was consistently lower in the simulator, suggesting higher mental workload in th
Abstract in Polish W artykule przedstawiam ogólne ujęcie relacji wartości. Jako punkt wyjścia przyjmuję szczególny typ relacji wartości, równorzędność, stanowiąca zdaniem Ruth Chang pewną postać porównywalności wartości, która różni się od trzech standardowych postaci porównywalności: lepszości, gorszości i równowartości. Joshua Gert zasugerował niedawno, iż pojęcie równorzędności można wyjaśnić, The paper provides a general account of value relations. It takes its departure in a special type of value relation, parity, which, according to Ruth Chang, is a form of evaluative comparability that differs from the three standard forms of comparability: betterness, worseness and equal goodness. Recently, Joshua Gert has suggested that the notion of parity can be accounted for, if value compariso
This paper brings to the fore the importance of a holistic approach to attaining a general pro-environmental behavioural change in order to reduce carbon emissions and the need to strive for a spillover of pro-environmental behaviour from one area to another. An adjusted version of the MaxSEM model is developed to capture differences in stages of behavioural change regarding environmental load on
Here, we present the activities within our research group over the last five yearswith cantilevers fabricated in the polymer SU-8. We believe that SU-8 is an interestingpolymer for fabrication of cantilevers for bio/chemical sensing due to its simple processingand low Young’s modulus. We show examples of different integrated read-out methodsand their characterisation. We also show that SU-8 cantil
The objective of this study was to evaluate the concentrations of nutrients in stumps and coarse roots in Norway spruce, Scots pine and silver birch in Sweden, Finland and Denmark, and to assess how nutrient concentrations vary with site characteristics, stand age and root size. Concentrations of nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg) and sodium (Na) in spruce, p
Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf
During the last decade women in Sweden have reduced men’s lead in participation in mathematics education and in professional careers as mathematicians. However, the development is uneven and slow overall. In some areas and at the highest levels women have increased their participation only marginally. Why, one may ask, is progress so slow after almost twenty years of active work from the Women and
