The effects of hormone and growth factor signaling on gene expression contribute significantly to breast tumorigenesis and disease progression; however, the targets of signaling networks associated with deregulated growth are not well understood. We defined the dynamic transcriptional effects elicited in MCF7, T-47D, and MDA-MB-436 breast cancer cell lines by nine regulators of growth and differen

In this report we will discuss the possibilities of defining a "good solution" of a system of linear equations. Ax=b where A is not necessarily quadratic. Especially the least squares problem will be treated. The concepts of pseudo inverses are introduced and its application to the least squares problem is shown. Geometrical interpretation of the solution in different cases is given. Different al

Universitetsläraren är för det mesta en pedagogisk amatör. En amatör är en "icke yrkesmässig utövare av något" men samtidigt en "älskare av något" (Wessén 1982). Med en lätt tolkning kan man alltså säga att en amatör utövar en verksamhet med kärleken som drivkraft. Detta kan då sättas i motsats till den professionelle utövaren som inte primärt har kärlek som drivkraft. En utvecklingstendens som i

Objectives. To compare perinatal and infant mortality in breech and cephalic presentations and between planned vaginal and cesarean section (CS) breech deliveries in Sweden. Methods. The study comprised two parts. Study A is a national cohort study for the period 1991-2001, including 22 549 breech presentations and 875 249 cephalic presentations born at >= 38 completed weeks. Study B is a case-con

Photon energy dependent intensity variations are experimentally observed in the L2,3M2,3M2,3 Auger spectra of argon clusters. Two cluster sizes are examined in the present study. Extrinsic scattering effects, both elastic and inelastic, involving the photoelectron are discussed and suggested as the explanation of the variations in the Auger signal. The atoms in the first few coordination shells su

Amperometric screen-printed biosensor arrays for detection of pesticides (organophosphates and carbamates) and phenols have been developed. Cholinesterases (AChE and BChE), tyrosinase (TYR), peroxidases (SBP. soybean and HRP. horseradish) and cellobiose dehydrogenase (CDH) were combined on the same array consisting of one Ag/AgCl reference electrode surrounded by eight radially distributed working

OBJECTIVE: Neuropeptide Y is a co-transmitter with noradrenaline in sympathetic neurons supplying arteries and veins with potent contractile effects. To investigate the role of neuropeptide Y in hypertension, we measured the circulating levels of neuropeptide Y and noradrenaline in patients with severe hypertension. DESIGN: Samples were collected from patients with untreated, severe hypertension (

This article presents reasons for undertaking "The Comparative Study of the Prevention of Crime and Violence by Mentally Ill Persons" and reasons for decisions regarding the study design and choice of measures. A brief portrait of the forensic patients that have been recruited is also presented. Community treatment programs could offer long-term cost-effective care for offenders with major mental

The aims of this study were to investigate if low-frequency fatigue (LFF) dependent on the duration of repeated muscle contractions and to compare LFF in voluntary and electrically induced exercise. Male subjects performed three 9-min periods of repeated isometric knee extensions at 40% maximal voluntary contraction with contraction plus relaxation periods of 30 plus 60 s, 15 plus 30 s and 5 plus

Antimicrobial peptides (AMP) are effector molecules of the innate immune system. A cross-functionality exists between AMPs and heparin-binding peptides. Here, we show that the peptides QPTRRPRPGTGPGRRPRPRPR-P (QPT22), derived from proline arginine-rich end leucine-rich repeat protein (PRELP) and KRFKQDGGWSHWSPWSS (KRF17) from thrombospondin exert antimicrobial activities against the Gram-negative

Aims Many patients with sinus node disease or atrioventricular block have previously received pacemakers with only ventricular stimulation (VVI or VVIR). This study aimed to investigate whether quality of life and cardiac function were affected by an upgrade to dual chamber pacing (DDDR or DDIR) following long-term ventricular stimulation. Methods After implantation of an atrial lead and a DDDR pu

The automotive industry is using more and more of Advanced High Strength Steel in order to reduce the weight of the car. Since this will generate more springback, it is of vital importance to be able to predict the amount of springback in the parts. Otherwise, many late changes have to be made in order to fit the parts in their position. In order to increase the ability to understand and test the

Specific inactivation of TGFbeta signaling in neural crest stem cells (NCSCs) results in cardiovascular defects and thymic, parathyroid, and craniofacial anomalies. All these malformations characterize DiGeorge syndrome, the most common microdeletion syndrome in humans. Consistent with a role of TGFbeta in promoting non-neural lineages in NCSCs, mutant neural crest cells migrate into the pharyngea

A new control strategy using feedback control has been developed for the multi-cylinder paper dryer configuration to reduce moisture transients in the drying section. The air system in the blow boxes was used to control the fast moisture transients in the paper machine. The new control system was combined with a previously developed physical model and was then compared with a conventional moisture

This paper presents a unified approach to multiscale detection of transient evoked otoacoustic emissions (TEOAEs). Using statistical detection theory, it is shown that the optimal detector involves a time windowing operation where the window can be estimated from ensemble correlation information. The detector performs adaptive splitting of the signal into different frequency bands using either wav

A study of the Slavonic translations of a Byzantine Greek world chronicle of the 10th c. AD. My study defines the importance of the Slavonic text for a student of the Greek text.