Myelin-sensitive quantitative (q) MRI techniques including MT (3D FLASH) and DTI (single-shot STEAM) are of growing importance to study white matter (WM) disorders in childhood. Cerebral folate transport deficiency is an inherited, treatable WM disorder with hypomyelination, developmental regression, movement disturbances, and epilepsy. One patient with this diagnosis and severe phenotype was trea

We have developed a combinatory antibody-antigen microarray for direct screening of multiple single-chain fragment variable (scFv) clones with no need for pre-purification or enrichment before screening. The straightforward workflow allows for early selection of binders to predefined peptide and glycopeptide targets. A capture antibody is contact printed on microarray slides, side by side with the

Understanding complex social-ecological systems, and anticipating how they may respond to rapid change, requires an approach that incorporates environmental, social, economic, and policy factors, usually in a context of fragmented data availability. We employed fuzzy cognitive mapping (FCM) to integrate these factors in the assessment of future wildfire risk in the Chiquitania region, Bolivia. In

This document demonstrates a conceptual study, design and development of unconventional electromagnetic actuators for applications where a high torque over a limited part of a rotational turn is required. The unconventionality of the actuators is that the electromagnetic actuation is applied directly on a high ratio transmission gear such as a cycloid disc in a cycloid drive or a flex-spline in a

In this paper, we describe a new system to extract, index, search, and visualize entities on Wikipedia. To carry out the extraction, we designed a high-performance entity linker and we used a document model to store the resulting linguistic annotations. The entity linker ,HERD, extracts the mentions from text using a string matching Engine and links the mto entities with a combination of rules, Pa

Background Dehydroepiandrosterone (DHEA) and its sulfated ester DHEA-sulfate (DHEA-S), (together DHEA[S]), are the most abundant adrenal steroids in humans and are found in blood and the brain, where they function as neurosteroids with direct receptor affinities. Preclinical studies suggest that DHEA(S) has antidepressant/neuroprotective properties, and exogenously administered DHEA has shown anti

Islet transplantation is a minimally invasive β-cell replacement strategy. Islet transplantation is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital (OUS) from January 2010 to June 2015. Patients were retrospectively divided into three groups. Thirteen patients received either one or two islet tran

Bacterial growth after freezing/thawing was studied in two soils with a history of annual freezing/thawing events. Soil samples were frozen for 1 week at −3 °C or −18 °C, thawed at +4 °C, and respiration and bacterial growth (estimated using leucine incorporation) were compared with reference soils kept at +4 °C. There were no major differences between soils. A respiration pulse, peaking within 9

Described is a method for preparing a purified liquid containing carbohydrates. The method comprises the steps of: hydrolysing starch to a dextrose equivalent (DE) of 10 or above, thus obtaining a liquid of carbohydrates; removing a heavy weight sludge fraction from the light weight liquid of carbohydrates using centrifugation; filtering the remaining liquid of carbohydrates, the filter being capa

An Eulerian Monte-Carlo approach, the so-called Eulerian stochastic fields (ESF) method is implemented and evaluated for simulation of non-premixed hydrogen/air combustion in supersonic flows. The ESF method is integrated into a compressible flow large eddy simulation (LES) solver, and validated on a supersonic combustor with a strut as flame-holder. Comparison with experimental data and with resu

Analysis of the pattern of proteins or messenger RNAs (mRNAs) in histological tissue sections is a cornerstone in biomedical research and diagnostics.This typically involves the visualization of a few proteins or expressed genes at a time. We have devised a strategy, which we call "spatial transcriptomics," that allows visualization and quantitative analysis of the transcriptome with spatial resol

The molecular epidemiology of HIV-1 in Iceland has not been described so far. Detailed analyses of the dynamics of HIV-1 can give insights for prevention of virus spread. The objective of the current study was to characterize the genetic diversity and transmission dynamics of HIV-1 in Iceland. Partial HIV-1 pol (1020bp) sequences were generated from 230 Icelandic samples, representing 77% of all H