Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are ne

The processes responsible for the formation of Earth's most conspicuous diversity pattern, the latitudinal diversity gradient (LDG), remain unexplored for many clades in the Tree of Life. Here, we present a densely sampled and dated molecular phylogeny for the most speciose clade of damselflies worldwide (Odonata: Coenagrionoidea) and investigate the role of time, macroevolutionary processes, and

Preclinical transplantations using human neuroepithelial stem (NES) cells in spinal cord injury models have exhibited promising results and demonstrated cell integration and functional improvement in transplanted animals. Previous studies have relied on the generation of research grade cell lines in continuous culture. Using fresh cells presents logistic hurdles for clinical transition regarding t

Evaluating the (Formula presented.) scaling function of elastic proton–proton ((Formula presented.)) collisions from recent TOTEM data at (Formula presented.) TeV and comparing it with the same function of elastic proton–antiproton ((Formula presented.)) data of the D0 collaboration at (Formula presented.) TeV, we find, from this comparison alone, an at least 3.79 (Formula presented.) signal of od

This thesis explores the relationship between French restrictive policies on the hijab and burqa and their impact on the human rights and fundamental freedoms of Muslim women. It likely delves into the historical context of these policies, analyses the legality and implications of such restrictions, and considers the broader sociocultural and political factors at play. It further examines the inte

This article explores the links between intolerance of urban noise and emerging notions of privacy in mid-eighteenth-century Altona, a southern provincial town in the Danish monarchy. It focuses on Johann Peter Willebrand (1719–86), who dealt with urban noise both as Altona’s police director and as an intellectual and author of several influential books on the ideal organization of early modern ci

Background This study aimed to describe the initial treatment of clubfoot deformity in Sweden using a national cohort. Secondarily we aimed to analyse the results of the initial treatment in relation to foot severity and additional diseases. Methods A national register, the Swedish Pediatric Orthopedic Quality Register, was used to extract data on children born with clubfoot in 2016–2019. Children

The interplay between aging and immune system deterioration presents a formidable challenge to human health, especially in the context of a globally aging population. Aging is associated with a decline in the body’s ability to combat infections and an increased risk of various diseases, underlining the importance of rejuvenating the immune system as a strategy for promoting healthier aging. In iss

Recasting Hume and Early Modern Philosophy is a collection of essays that are all concerned with major figures and topics in the early modern philosophy. Most of the essays are concerned, more specifically, with the philosophy of David Hume (1711-1776). The sixteen essays included in this collection are divided into five parts. These parts are arranged under the headings of: (1) Metaphysics and Ep

Swedish translation of the poetry collection "The Curious Thing" (2021)

This chapter presents an interpretation of Bernard Williams’s significant and substantial contributions on the topic of free will and moral responsibility. Williams’s fundamental objective, it is argued, is to vindicate moral responsibility by way of freeing it from distortions and misrepresentations imposed on it by “the morality system.” Although his earlier work is primarily concerned with the

Safe and clean drinking water delivery is challenged by climate change, as elevated temperatures can promote the growth of pathogens and other detrimental microorganisms. The microbial processes underlying drinking water production in slow sand filters (SSFs) are largely uncharacterized, limiting the possibilities of improving this technology. Periodical clogging, potentially by microbes, disrupts

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi a

BakgrundLångvarig behandling med opioida läkemedel, här definierat som> 3 månader, på indikation långvarig icke-malign smärta är vanligt förekommande i smärtvården. Vid undersökningar i Lund och Linköping har noterats att ungefär en tredjedel av populationen vid smärtklinikerna exponeras för opioidbehandling, trots avsaknad av evidens och samtidigt väl kända risker med behandlingen. Nedtrappning a

A healthy working life is fundamental for individuals and society. To date, increasingly research connects the earlier, pre-working life to later working life experiences and beyond, recognizing that a worker’s health and exposure starts before the working life begins. The research, however, often lacks a fundamental understanding of (i) the underlying mechanisms and pathways accounting for differ