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WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells

An important role for WNT-5A is implicated in a variety of tumors, including breast carcinoma. We previously showed that WNT-5A signaling inhibits migration and metastasis of breast cancer cells, and that patients with primary breast cancer in which WNT-5A was expressed have a better prognosis. Despite the fact that RhoGTPase Cdc42 is commonly associated with increased cell migration, we here show

The Democratic Legitimacy of Refugee Law

Having left their home country, 18 million refugees and other protection seekers cannot exert their rights to democratic participation. As a consequence, they are deprived of all influence on a legal instrument of existential importance for them, namely the grant of asylum. Can the exclusion of refugees from the framing of aliens legislation be justified?The analysis carried out in this text proce

Strict Ethics Regulation Without Appropriate Institutional Implementation Won’t Protect Decisionally Incapacitated Research Subjects: Lessons fom Sweden

The standard requirement of informed consent cannot be met when potential research subjects are decisionally incapacitated due to e.g. dementia, intellectual disabilities, or other mental health problems. Such research subjects are generally recognized as being in need of special protection, particularly when the relevant research cannot be expected to benefit the participating individuals themsel

Treatment outcome in male Gambling Disorder patients associated with alcohol use

Aims: The primary objective of this study was to analyze the association between alcohol consumption and short-term response to treatment (post intervention) in male patients with gambling disorder enrolled in a group cognitive behavioral therapy (CBT) program. Methods: The sample consisted of 111 male individuals with a diagnosis of Gambling Disorder, with a mean age of 45 years (SD = 12.2). All

Long-term unemployment and violent crime

This study reinvestigates the relationship between unemployment and crime, but is the first to focus explicitly on the effects of long-term unemployment on crime. A unique finding is that long-term unemployment shows a strong association with violent crime, an effect which is greater than that of total unemployment on property crime in this and most previous studies. Long-term unemployment thus id

Anti-vibration gloves - in theory and practice

Are anti-vibration gloves the solution to the problem of hand-arm vibration?Vibrations from hand-held machinery are a major problem in the Swedish labour force. In 2009, 14% of men and 3% of women of employed in Sweden reported exposure to hand-arm vibration at least a quarter of their working time according to the Swedish Work Environment Authority (Arbetsmiljöverket 2010). It is tempting to imag

The Status of Mythology in Sixteenth Century Lutheran Collections of Aesopic Fables

In the ancient corpus of Aesopic fables gods and semi-gods from Greek and Roman mythology often appear. Most commonly Zeus is called upon by fable characters such as the donkey, the snake, and the turtle, all of them pleading for a better destiny. Frequent main characters, rather often promoting their own interests in the fable fictions, are also Hera, Herakles, Apollo, and Hermes. The high esteem

Film International Issue 12

Contents: Planet Osaka: Independent Japanese Film (Johannes Schönherr), Interview with Walter Hill: Last Man Standing (Patrick McGilligan), False Criticism: Cinema and the Conservative Critique of Bourgeois Society (Christopher Sharrett), Hollywood/Taiwan: Connections, Countercurrents and Ang Lee's Hulk (Gina Marchetti), Louise Brooks: The Martyrdom of Lulu (Dan Callahan). Reviews: film festivals.

Public safety investigations-A new evolutionary step in safety enhancement?

A historical overview highlights the evolutionary nature of developments in accident investigations in the transport industry. Based on a series of major events outside transportation, the concept of accident investigations has broadened to other domains and to a widening of the scope of the investigation. Consequently, existing investigation boards are forced to adapt their mandates, missions and

The Non-admission and Return of Protection Seekers in Germany

Since the German reform of asylum law in 1993, statistics indicate a significant decrease of protection claims and an increasing number of deportations. This article presents relevant domestic legislation and international agreements contributing to this development It focuses on how domestic and international law interact to inhibit or end the presence of protection seekers on German territory. I

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On the way to parenthood - (re)productions of gender, ethnicity, race and class in midwife consultations.The premise of this article is that subject positions, which parents-to-be hold during pregnancy, influence their future parenthood. The article examines how such subject positions are produced in midwife consultations. It shows how the man in a heterosexual couple is positioned as peripheral w

The WAIS Divide deep ice core WD2014 chronology - Part 2 : Annual-layer counting (0-31 ka BP)

We present the WD2014 chronology for the upper part (0-2850 m; 31.2 ka BP) of the West Antarctic Ice Sheet (WAIS) Divide (WD) ice core. The chronology is based on counting of annual layers observed in the chemical, dust and electrical conductivity records. These layers are caused by seasonal changes in the source, transport, and deposition of aerosols. The measurements were interpreted manually an