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Uncertainty quantification, propagation and characterization by Bayesian analysis combined with global sensitivity analysis applied to dynamical intracellular pathway models

Motivation: Dynamical models describing intracellular phenomena are increasing in size and complexity as more information is obtained from experiments. These models are often over-parameterized with respect to the quantitative data used for parameter estimation, resulting in uncertainty in the individual parameter estimates as well as in the predictions made from the model. Here we combine Bayesia

Osteoporosis knowledge and awareness among university students in Saudi Arabia

Awareness and knowledge about any disease is the first step to prevent and treat it, so this study evaluates osteoporosis awareness and knowledge in university students. Our results showed a high awareness and good knowledge of osteoporosis. Females were better informed than males. Knowledge increased with increasing education level. PURPOSE: Osteoporosis is a worldwide health problem, including S

Using a Targeted Proteomics Chip to Explore Pathophysiological Pathways for Incident Diabetes- The Malmö Preventive Project

Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes

Familial risk for soft tissue tumors : A nation-wide epidemiological study from Sweden

Purpose: Reliable data on familial risks are important for clinical counseling and cancer genetics. However, population-based studies on familial soft tissue tumors are limited, which we will examine. Methods: Adjusted standardized incidence ratios (SIRs), calculated from the nation-wide Swedish Family Cancer Database, were used to measure the familial risk. Results: There were 17 offspring-parent

Coronary heart disease risks in first- and second-generation immigrants in Sweden : a follow-up study

OBJECTIVES: To analyse whether there is an association between country of birth in first-generation immigrants and first hospitalization for or death from coronary heart disease (CHD) and to analyse whether this association remains in second-generation immigrants.DESIGN: In this follow-up study, the MigMed database at the Karolinska Institute, Stockholm, was used to identify all hospital diagnoses

A comparative evaluation of flood mitigation alternatives using GIS-based river hydraulics modelling and multicriteria decision analysis

A multicriteria framework is developed for the selection of optimal flood mitigation and river training measures in a selected reach of Zaremroud River in Northern Iran. A river model, Hydrologic Engineering Center River Analysis System, combined with geographic information system analysis is used to simulate water levels for steady, gradually varied flow and mapping inundated flood extents. The m

Bone mineral mass in hip fracture patients

The aims of this study were to measure the bone mineral density (BMD) and some anthropometric variables in patients with hip fracture, to compare these data with those from controls, and to compare the fractured and unfractured hip. Bone mineral measurements with dual energy X-ray absorptiometry (DEXA) were undertaken in 93 consecutive hip fracture patients, 26 men and 67 women, with a mean age of

Bone mineral density in weight lifters

The effect of intense physical training on the bone mineral content (BMC) and soft tissue composition, and the development of these values after cessation of the active career, was studied in 40 nationally or internationally ranked male weight lifters. Nineteen were active and 21 had retired from competition sports. Fifty-two age- and sex-matched nonweight lifters served as controls. The bone mine

Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue

Alpha 1-Microglobulin (alpha 1-m), or protein HC, a low molecular weight plasma protein with immunoregulatory properties, was isolated from rat serum by affinity chromatography using Sepharose-coupled monoclonal anti-alpha 1-m antibodies. High molecular weight forms of alpha 1-m were then separated from the low molecular weight alpha 1-m by gel chromatography of the eluted proteins. The apparent M

Changes in the Prevalence of Embryologic Remnants in Umbilical Cord With Gestational Age

The aim of this study was to examine the prevalence of embryologic remnants in umbilical cords of different gestational ages. Sections from 392 umbilical cords were examined using light microscopy. Of these, 52% contained at least 1 remnant, most commonly of the allantoic duct type. Although there was a significant decrease in vitelline duct remnants over increasing gestational age, from 11% at we

Christmas, national holidays, sport events, and time factors as triggers of acute myocardial infarction : SWEDEHEART observational study 1998-2013

Objectives To study circadian rhythm aspects, national holidays, and major sports events as triggers of myocardial infarction. Design Retrospective observational study using the nationwide coronary care unit registry, SWEDEHEART. Setting Sweden. Participants 283 014 cases of myocardial infarction reported to SWEDEHEART between 1998 and 2013. Symptom onset date was documented for all cases, and tim

Daylight regulation compliance of existing multi-family apartment blocks in Sweden

This research investigates the daylight regulation compliance of existing multi-family housing developments located primarily in Stockholm (Lat.: 59,33 °N), Sweden. A representative sample of 54 buildings consisting of 10.888 individual rooms was modelled according to archived documentation drawings and evaluated by use of Radiance simulations, to test their compliance with the current Swedish day