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Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population

We examined the associations of intake of vegetables, legumes and fruit with all-cause and cause-specific mortality in a population with prevalent diabetes in Europe. A cohort of 10,449 participants with self-reported diabetes within the European Prospective Investigation into Cancer and Nutrition study was followed for a mean of 9 y. Intakes of vegetables, legumes, and fruit were assessed at base

The restricted active space followed by second-order perturbation theory method: Theory and application to the study of CuO(2) and Cu(2)O(2) systems.

A multireference second-order perturbation theory using a restricted active space self-consistent field wave function as reference (RASPT2/RASSCF) is described. This model is particularly effective for cases where a chemical system requires a balanced orbital active space that is too large to be addressed by the complete active space self-consistent field model with or without second-order perturb

Transient aggregation and stable dimerization induced by introducing an Alzheimer sequence into a water-soluble protein

Transient contacts between denatured polypeptide chains are likely to play an important part in the initial stages of protein aggregation and fibrillation. To analyze the nature of such contacts, we have carried out a protein engineering study of the 102-residue protein U1A, which aggregates transiently in the wild-type form during refolding from the guanidinium chloride-denatured state. We have p

The global burden of diabetic foot disease

Diabetic foot problems are common throughout the world, resulting in major economic consequences for the patients, their families, and society. Foot ulcers are more likely to be of neuropathic origin, and therefore eminently preventable, in developing countries, which will experience the greatest rise in the prevalence of type 2 diabetes in the next 20 years. People at greatest risk of ulceration

Root competition influences pollen competitive ability in Viola tricolor: effects of presence of a competitor beyond resource availability?

1. It has recently been suggested that not only nutrients but also presence of a competitor can influence competitive ability in plants, for example, by strategic changes in allocation to roots (a 'tragedy of the commons' effect). Such strategic changes might occur also in pollen, because this has potential to increase siring success during pollen competition in the pistil. 2. I tested the new hyp

Rapid one-step whole blood C-reactive protein magnetic permeability immunoassay with monoclonal antibody conjugated nanoparticles as superparamagnetic labels and enhanced sedimentation

A rapid (5.5 min) one-step whole blood C-reactive protein (CRP) magnetic permeability immunoassay utilizing monoclonal antibody conjugated dextran iron oxide nanoparticles (70 nm) as superparamagnetic labels and mixed fractions (1:1 ratio of 15-40 and 60 mu m) of polyclonal anti-CRP conjugated silica microparticles for enhanced sedimentation is described. In this one-step assay procedure, a whole

Bacterial growth on allochthonous carbon in humic and nutrient-enriched lakes: Results from whole-lake C-13 addition experiments

Organic carbon (C) in lakes originates from two distinct sources-primary production from within the lake itself (autochthonous supply) and importation of organic matter from the terrestrial watershed (allochthonous supply). By manipulating the C-13 of dissolved inorganic C, thereby labeling within-lake primary production, we examined the relative importance of autochthonous and allochthonous C in

Monitoring brown frogs Rana arvalis and Rana temporaria in 120 south Swedish ponds 1989-2005. Mixed trends in different habitats

The two brown frogs Rana arvalis and Rana temporaria were monitored at 57 localities (that contained a total of 120 ponds) for up to 17 years each during the years 1989-2005. The analysis summarized below only accounts for trends within sites actually usable for frogs during the analysis period, large scale habitat losses are thus not accounted for. R. arvalis populations tended to increase over t

Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus

This study was performed to investigate the relation between IgG autoantibodies against human C-reactive protein (antiCRP) and disease activity measures in serial serum samples from 10 patients with systemic lupus erythematosus (SLE), of whom four had active kidney involvement during the study period. The presence of anti-CRP was analysed by enzyme-linked immunosorbent assay. The cut-off for posit

Recombinant human factor VIIa and a factor VIIa-analogue reduces heparin and low molecular weight heparin (LMWH)-induced bleeding in rats

Background: Heparin and low molecular weight heparin (LMWH) are widely used for prevention and treatment of thromboemobolic events, but may occasionally cause uncontrollable bleeding. Heparin can readily be antagonized with protamine, but this is less effective against LMWH. Objectives: To test the effects of rFVIIa or an analogue of rFVIIa, NN1731, on heparin- and LMWH-induced bleeding in rats. M

A microcalorimetric study of water vapor sorption on morphine sulphate

Water vapor sorption on morphine sulphate was studied in a twin double sorption microcalorimeter at 25°C. The vapor sorption isotherm and the differential heats of sorption were determined simultaneously from dry condition to a water activity of 0.99. Two well resolved hydration steps were obtained on the sorption isotherm at water activities of 0.01 and 0.22 corresponding to the formation of dihy

Educational priorities and current involvement in genetic practice: a survey of midwives in the Netherlands, UK and Sweden

Objective: to investigate whether practising midwives are adequately prepared to integrate genetic information into their practice. Design: a cross-sectional, postal, structured questionnaire survey was sent to practising midwives. Setting: practising midwives from the Netherlands (NL), Sweden (SE) and the United Kingdom (UK). Participants: 1021 replies were received, achieving a response rate of

Terahertz conductivity and possible Bloch gain in semiconductor superlattices

We have investigated terahertz emission due to dynamical electron transport in wide-miniband GaAs/Al0.3Ga0.7As superlattices. By noting that the time-domain THz emission spectroscopy inherently measures the step-response of the electron system to the bias electric field, the obtained THz spectra were compared with the high-frequency conductivities predicted for miniband transport. Excellent agreem

Modelling of pulverised wood combustion using a functional group model

Modelling of pulverised wood flames in a laboratory vertical furnace was carried out. The aim was to gain deeper understanding of the combustion process and to validate a mathematical model to simulate the process. Pulverised wood combustion involves many different processes such as two-phase flow dynamics, drying and devolatilisation of the particles, oxidation of the volatile and formation and o

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences hepa

Methodology for identifying particle sources in indoor environments

Growing concern about airborne particles in indoor environments requires fast source identification in order to apply remedial actions. A methodology for identifying sources emitting particles larger than 0.5 mu m was designed and applied. It includes: (1) visual inspection of interior surfaces in order to identify deposited particles and inspection of potential sources (equipment, materials. acti

Country of birth, instrumental activities of daily living, self-rated health and mortality: a Swedish population-based survey of people aged 55-74.

There is scant knowledge of the effects of country of birth on the health of individuals in the years prior to and after retirement. The aim of this study was to consider country of birth in relation to health status, instrumental activities of daily living (IADL) and all-cause mortality when adjusted for socioeconomic status (SES). Cross-sectional data were collected between 1986 and 1991 on 8959

Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)

Previous studies suggested a link between the use of G-CSF and increased incidence of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) after immunosuppressive therapy (IST) for severe aplastic anemia (SAA). This European survey included 840 patients who received a first-line IST with (43%) or without (57%) G-CSF. The incidences of MDS/AML in patients who did or did not receive G-CSF