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Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders b

Triglycerides in the beta-cell may be important for stimulus-secretion coupling, through provision of a lipid-derived signal, and for pathogenetic events in NIDDM, where lipids may adversely affect beta-cell function. In adipose tissues, hormone-sensitive lipase (HSL) is rate-limiting in triglyceride hydrolysis. Here, we investigated whether this enzyme is also expressed and active in beta-cells.

Recension av Ulf Drugge & Mats Johansson (red.); Historisk sociologi.

Higher bone mineral density (BMD) has been reported in weight-loaded skeletal regions and lower BMD in unloaded regions in active athletes compared with controls. These discrepancies remain the first decades after cessation of active careers in former athletes with no remaining discrepancies found after age 65 years compared with age- and gender-matched controls. Physical activity is reduced after

The aim of this work is to generate detailed and simplified kinetic models for the oxidation of the Primary Reference Fuels (PRF) n-heptane, iso-octane and their mixtures, with low numbers of species and reactions. These mechanisms are consistent in terms of the choice of kinetic parameters for the different reaction classes. The further aim is to validate the kinetic models for a wide range of di

It has been demonstrated that prostate-specific antigen (PSA), in spite of its name, can be detected in body fluids and tumors from a variety of organs. Investigations have shown that human glandular kallikrein 2 (hK2), a related prostate-secreted protease, can activate the zymogen form of PSA, suggesting that the two enzymes might work as a functional unit, with hK2 as the activator molecule and

The fundamental problems related to uncertainty in quantitative risk analyses, used in decision making in safety-related issues (for instance, in land use planning and licensing procedures for hazardous establishments and activities) are presented and discussed, together with the different types of uncertainty that are introduced in the various stages of an analysis. A survey of methods for the pr

The advent of Java and similar languages on the real-time system scene necessitates the development of efficient strategies for scheduling the work of a garbage collector in a non-intrusive way. We propose a scheduling strategy, time-triggered garbage collection, based on assigning the collector a deadline for when it must complete its current cycle. We show that a time-triggered CC with fixed dea

Emendation av ett korrupt ställe i ett Birgittaofficium

The paper addresses the issue of so-called functional foods, i.e. a specific type of health foods. The basic idea is that the claims made in the framing of these products have the character of modem myths. The myth structure discursively obscures the ideologically loaded scientific/medical premises on which the claims are resting. Rather than being healthy in an absolute sense, these products are

Concrete deteriorates due to many different mechanisms. Among the most important mechanisms is the reinforcement corrosion induced by deleterious substances reaching the embedded reinforcement bars. The external sources of deleterious materials may, for example, be deicing salts, sea water, and carbon dioxide. Research has sought to determine threshold values, in terms of concentration of deleteri

Multistep methods are classically constructed by specially designed difference operators on an equidistant time grid. To make them practically useful, they have to be implemented by varying the step-size according to some error-control algorithm. It is well known how to extend Adams and BDF formulas to a variable step-size formulation. In this paper we present a collocation approach to construct v

Interactions between amphiphilic alpha-helical human apolipoprotein CI (APO CI) adsorbed on hydrophilic and on hydrophobic surfaces were studied using an interferometric surface force apparatus in an effort to understand the surface conformation and the binding activity of this protein. We used mica as the hydrophilic substrate and polymerized octadecyltriethoxysilane (OTE)-covered mica as the hyd

This paper reports on the optimization of steam pretreatment of barley husk for high pentose and hexose recovery in the subsequent enzymatic hydrolysis step, as well as high ethanol yield, following simultaneous saccharification and fermentation. The parameters optimized in the steam pretreatment step were residence time (5-15 min), temperature (190-215 degreesC), and concentration of the acid cat

Subjects with impaired glucose tolerance (IGT) are usually overweight and exhibit insulin resistance with a defective compensation of insulin secretion. In this study, we sought to establish the interrelation between insulin secretion and insulin sensitivity after oral glucose in non-obese subjects with IGT and we also examined this interrelation in relation to the 2 main incretins, glucagon-like