Chimney sweeps have higher incidence and mortality of cardiovascular disease (CVD), likely related to their exposure to polycyclic aromatic hydrocarbons (PAH). In order to identify underlying mechanisms of PAH-related CVD, we here investigated whether PAH exposure was associated with levels of putative CVD-related proteins in serum among currently working chimney sweeps. We enrolled 116 chimney sw

Background: Prenatal exposure to mixtures of endocrine disrupting chemicals (EDC) has the potential to disrupt human metabolism. Prenatal periods are especially sensitive as many developmental processes are regulated by hormones. Prenatal exposure to EDCs has inconsistently been associated with children's body mass index (BMI) and obesity. The objective of this study was to investigate if prenatal

Background: Pesticide use is increasing in low- and middle-income countries (LMICs) including Costa Rica. This increase poses health risks to farm owners, farm workers, and communities living near agricultural farms. Objective: We aimed to examine the health effects associated with occupational pesticide exposure in farm owners and workers from conventional and organic smallholder farms in Costa R

Urban environments are often seen as the opposite of natural environments, with the belief that the built cannot accommodate the natural. However, this is a false perception. Ecological systems within urban environments are of great importance and can provide microclimates and habitats that do not exist in surrounding areas. Yet, this quality is rarely utilized because of the perception that built

This book is the first to address the important interrelationship between second homes and climate change, which has become an increasingly relevant issue for many regions around the world. Second homes are often a key source of tourist visitation as well as economic benefit for their host communities. The chapters provide an array of international case studies and climate change impacts, includin

BACKGROUND: In cancer, genomic rearrangements can create fusion genes that either combine protein-coding sequences from two different partner genes or place one gene under the control of the promoter of another gene. These fusion genes can act as oncogenic drivers in tumor development and several fusions involving kinases have been successfully exploited as drug targets. Expressed fusions can be i

This thesis examines the strategies adopted and the challenges professionals face while providing cognitively disabled youths with sexual education. The study was conducted via qualitative interviews of professionals working with cognitively disabled youth, ranging between teachers, youth club workers, and sexual health educators. The thesis’ chief findings showed that professionals adopted the st

The human brain can be described as a complex network of functional connections between distinct regions, referred to as the brain functional network. Recent studies show that the functional network is a dynamic process and its community structure evolves with time during continuous task performance. Consequently, it is important for the understanding of the human brain to develop dynamic communit

Aims: Pleural mesothelioma (PM) is a highly aggressive thoracic tumour with poor prognosis. Although reduced tissue drug accumulation is one of the key features of platinum (Pt) resistance, little is known about Pt distribution in human PM. Methods: We assessed Pt levels of blood samples and surgically resected specimens from 25 PM patients who had received neoadjuvant Pt-based chemotherapy (CHT).

Många anläggningar projekteras idag under jord. Det gör att det tillkommer krav på vattentätning av berget. Ett sätt att vattentäta en konstruktion är att använda dukmembran eller tunnelduk. Dock råder det oklarheter hur provningsmetoderna för brandklassificering och standarder skiljer sig internationellt. I en alltmer globaliserad värld är det viktigt att provningsmetoderna jämförs med varandra,

Collagen is the main organic building block of musculoskeletal tissues. Despite collagen being their smallest load bearing unit, these tissues differ significantly in mechanical function and properties. A major factor behind these differences is their hierarchical organization, from the collagen molecule up to the organ scale. It is thus of high importance to understand the characteristics of each

Context:Bug reports created during software development and maintenance do not always describe deviations from a system’s valid behavior. Such invalid bug reports may consume significant resources and adversely affect the prioritization and resolution of valid bug reports. There is a need to identify preventive actions to reduce the inflow of invalid bug reports. Existing research has shown that m

För att minska utsläppen av växthusgaser har nationella och internationella mål satts upp som medfört att andelen energi från förnyelsebara intermittenta energikällor kommer att öka. Ett resultat av detta är en mer komplex energimarknad och ett ökat behov av energilagring för att överbrygga gapet mellan produktion och efterfråga i tid och rum. En teknisk lösning som föreslås i Europeiska och Svens

The report compares climate migration cases in Sweden and Austria, establishing a quantitative measure plus legal and policy analysis.

In Europe thyroid ultrasound has been used at outpatient endocrine clinics since many years, and in southern Sweden only during the last years. Ultrasound has a role in the investigation of Graves' disease, subacute thyroiditis, gestational thyrotoxicosis, postpartum thyroiditis, amiodarone thyrotoxicosis and goiter with or without adenoma, but adenomas are usually investigated by endocrine surgeo