Synthesis of sialic acid 4-C derivatives through alkyne nucleophilic addition with the ambition to develop efficient inhibitors of bacterial transport proteins
Antimicrobial resistance is according to the World Health Organization (WHO) one of the most rapidly growing threats to world health. According to a recently published WHOreport, drug resistant microbials could be responsible for up to 10 million annual deaths by the year 2050 unless drastic measures are taken such as decreasing misuse and developing new antibiotics. This work explores the possibi