BACKGROUND: Benchmark datasets are essential for both method development and performance assessment. These datasets have numerous requirements, representativeness being one. In the case of variant tolerance/pathogenicity prediction, representativeness means that the dataset covers the space of variations and their effects.RESULTS: We performed the first analysis of the representativeness of variat

This article uses the concept of cultural citizenship to understand engagement in political comedy. The concept stresses popular culture’s value for identity and community construction, as well as the importance of learning about and respecting others. Using empirical work on Swedish young adult political comedy audiences in the form of data from in-depth interviews and focus groups, the article a

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when w

This paper focuses on the use of the Compound Past (CP) found in a set of epistolary letters from the 18th and 19th centuries' Uruguay. It is claimed that the CP already at this time encodes situations that are conceptualized within a temporal frame of indeterminacy. All the cases of CP in 66 letters are analyzed according to its contexts – with or without temporal determinants; in colocational en

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with as

Background: The EsPhALL2004 randomised trial showed a 10% advantage in disease-free survival for short, discontinuous use of imatinib after induction compared with no use of imatinib in patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia receiving Berlin-Frankfurt-Münster chemotherapy and haemopoietic stem-cell transplantation (HSCT). Other contemporary studies showed an a

Vi som gick i grundskolan under 70- och 80-talet minns att lektionerna med jämna mellanrum bröts av att det plötsligt knackade på dörren varpå en vitklädd kvinna klev in bärandes en bricka med små muggar. Det var dags för fluorsköljning. En aktivitet som hade försvinnande lite att göra med matematik, svenska eller vad det nu var för ämne man för stunden var engagerad i. Jag skulle vilja kalla dett

Understanding nanoparticle catalysis requires novel approaches in which adjoining crystal orientations can be studied under the same reactive conditions. Here we use a curved palladium crystal and near-ambient pressure X-ray photoemission spectroscopy to characterize chemical species during the catalytic oxidation of CO in a whole set of surfaces vicinal to the (111) direction simultaneously. By s

Heritopia explores the multiple meanings of the past in the present, using the famous temples of Abu Simbel and other World Heritage sites as points of departure. It employs three perspectives in its attempt to understand and explain both past and present: the truth of knowledge, the beauties of narrative, and ethical demands. Crisis theories are rejected as nostalgic expressions of contemporary s

In Ag-Cu oxides possible to fabricate so far, superconductivity has not been detected, but high conductivity was. In the quest for superconductivity the demand is to create a high and peculiar copper-oxygen coordination. Such coordination makes it non-trivial to determine Cu oxidation states, which may be several and co-existing. Another reason for uncertainty is in oxygen deficiency typical for s

BACKGROUND: To investigate the outcome of an integrated individual and family therapy (Intensive Contextual Treatment: ICT) in terms of reducing suffering and increasing functional adjustment among self-harming and/or suicidal adolescents with high symptom loads and their families. METHODS: Forty-nine self-harming and/or suicidal adolescents, Mage = 14.6, of predominantly Swedish origin and female

Planar droplet sizing (PDS) is a technique relying on the assumption that laser-induced fluorescence (LIF) and Mie scattering optical signals from spherical droplets depend on their volume and surface area, respectively. In this article, we verify the validity of this assumption by experimentally analyzing the light intensity of the LIF and Mie optical signals from micrometric droplets as a functi

An N-heterocyclic carbene palladium(II) complex containing two anthracene side arms was immobilized on the surface of reduced graphene oxide (rGO) by π-stacking. The activity of the homogeneous analogue and the supported complex in undirected C–H acetoxylation reaction of arenes was studied. The results show that the catalytic efficiency in acetoxylation of benzene is improved in the immobilized m

Background: Multimorbidity has already become common in primary care and will be a challenge in the future. Primary care in Sweden participates to a great extent in the care of patients with two severe, chronic conditions: chronic obstructive pulmonary disease (COPD) and heart failure. Both conditions are characterized by high mortality and often coexist. Age, sex, heart failure and other comorbid

Många medarbetare och chefer i offentlig sektor vittnar om hur detaljstyrning, överdriven formbundenhet och felriktad mätning hindrar dem från att göra ett gott arbete. De upplever att verksamheten styrs och leds med fjärrkontroll och med bristande lyhördhet för behoven längst ut i styrkedjan. Forskningen pekar i samma riktning. Det här leder inte bara till minskad motivation och arbetsglädje, uta

BACKGROUND: Hip fractures are a common problem in the ageing population. Hip arthroplasty is the common treatment option for displaced intracapsular neck of femur fractures. Even though hip replacements are successful in restoring mobility, reducing pain and diminishing loss of health-related quality of life, the potential impact of a hip fracture on life expectancy as well as the postoperative mo