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Background Therapeutic drug monitoring (TDM) of antibiotics in children is of fundamental importance for effective patient management. The use of dried blood spot (DBS) offers a number of advantages over conventional blood collection. The aim of this study is to develop and validate a method to measure piperacillin/tazobactam in DBS. Results The analysis was performed by using LC-MS/MS operating i
This paper deals with a continuous review inventory system with Poisson demand, in which lateral transshipments are allowed. In case of a shortage at a location, another location acts as a supplier, if it is possible. A common assumption in earlier papers is that transshipments are allowed between all locations. This network configuration may, however, not be the best choice for many reasons. one
Book review
Breast cancer survival is reportedly higher in the US than in Europe. The first worldwide study (CONCORD) found wide international differences in age-standardized survival. The aim of this study is to explain these survival differences. Population-based data on stage at diagnosis, diagnostic procedures, treatment and follow-up were collected for about 20,000 women diagnosed with breast cancer aged
Leadership development theory and practice is increasingly turning its gaze on identity as a primary focus for development efforts. Most of this literature focuses on how the identities of participants are strengthened, repaired and evolved. This article focuses on identity work practices that are underdeveloped in the literature: the deconstruction, unravelling and letting go that can be experien
By the beginning of 1990, three third-generation synchrotron light sources had been successfully commissioned in Grenoble, Berkeley and Trieste (ESRF, ALS and ELETTRA). Each of these new machines reached their target specifications without any significant problems. In parallel, already at that time discussions were underway regarding the next generation, the `diffraction-limited light source (DLSR
OBJECTIVE: To evaluate compliance with screening and prevalence of abdominal aortic aneurysm (AAA) in relation to background data regarding area-based socioeconomic status. METHODS: Our department annually invites 4300 65-year-old men from the city of Malmö and 15 neighboring municipalities to ultrasound AAA screening. In a cross-sectional cohort study, compliance and AAA prevalence among 8269 men
Hypertension clusters in families. However, no nationwide study has investigated the family history as a predictor of hospitalization for hypertension, which was the purpose of this study.
Large (> 1m) deformable mirrors with hundreds or thousands of actuators are attractive for extremely large telescopes. Use of force actuators coupled to the mirror via suction cups, and electret microphones for position sensing, has the potential of substantially reducing costs. However, a mirror controlled with force actuators will have many structural resonances within the desired system bandwid
Abstract in UndeterminedThe topology optimization problem is formulated in a phase-field approach. The solution procedure is based on the Allan–Cahn diffusion model where the conservation of volume is enforced by a global constraint. The functional defining the minimization problem is selected such that no penalization is imposed for full and void materials. Upper and lower bounds of the density f
The aim of this study was to investigate whether the previously reported differences in cognitive performance as assessed using a Stroop paradigm between individuals with and without tinnitus is present in normal-hearing individuals.
The Last Interglacial Period (LIP) is often regarded as a good analogue for potential climatic conditions under predicted global warming scenarios. Despite this, there is still debate over the nature, duration and frequency of climatic changes during this period. One particularly contentious issue has been the apparent evidence of climatic instability identified in many marine cores but seemingly
Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. In this study metabolomics was used to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before eight
Terrestrial ecosystem models are employed to calculate the sources and sinks of carbon dioxide between land and atmosphere. These models may be heavily parameterised. Where reliable estimates are unavailable for a parameter, it remains highly uncertain; uncertainty of parameters can substantially contribute to overall model output uncertainty. This paper builds on the work of the terrestrial Carbo
We explore the influence of ion pairing in room temperature ionic liquids confined by planar electrode surfaces. Using a coarse-grained model for the aromatic ionic liquid [C4MIM(+)][BF4 (-)], we account for an ion pairing component as an equilibrium associating species within a classical density functional theory. We investigated the resulting structure of the electrical double layer as well as t
Background: Increased expression of cyclooxygenase-2 (COX-2) is common in non-small cell lung cancer (NSCLC) and has been associated with poor prognosis. Experimental and clinical phase II trials have indicated that the addition of the COX-2 inhibitor celecoxib to palliative chemotherapy might increase survival time in patients with advanced NSCLC. Methods: We performed a double-blind, placebo-con
Transformation-based learning (TBL) is a machine learning method for, in particular, sequential classification, invented by Eric Brill [Brill 1993b, 1995a]. It is widely used within computational linguistics and natural language processing, but surprisingly little in other areas. TBL is a simple yet flexible paradigm, which achieves competitive or even state-of-the-art performance in several area
Narcolepsy is a lifelong sleep disorder related to hypocretin deficiency resulting from a specific loss of hypocretin-producing neurons in the lateral hypothalamic area. The disease is thought to be autoimmune due to a strong association with HLA-DQB1*06:02. In 2009 the World Health Organization (WHO) declared the H1N1 2009 flu pandemic (A/H1N1PDM09). In response to this, the Swedish vaccination c
