Objective: To evaluate if remission induced by low-dose prednisolone during the first 2 years of rheumatoid arthritis (RA) in the BARFOT glucocorticoid (GC) study had a sustained effect on radiological damage for a total of 4 years. Methods: A total of 150 of 211 eligible patients with RA who had been randomised to the 7.5 mg prednisolone group ( P) or no prednisolone group (NoP) in addition to th

This study focuses on the statistical description and analysis of road surface irregularities that are essential for heavy-vehicle fatigue assessment. Three new road profile models are proposed: a homogenous Laplace moving average process, a non-homogenous Laplace process and a hybrid model that combines Gaussian and Laplace modelling. These are compared with the classical homogenous Gaussian proc

Introduction: This paper reports results from an ethnographic study of teacher trainees’ information activities in digital, group-based learning and their relation to the interplay between use and appropriation of digital tools and the learning environment. Method. The participants in the present study are 249 pre-school teacher trainees in Sweden. Three key informants and their teams were followe

An expectation in soil ecology is that a microbial communities' fungal:bacterial dominance indicates both its response to environmental change and its impact on ecosystem function. We review a selection of the increasing body of literature on this subject and assess the relevance of its expectations by examining the methods used to determine, the impact of environmental factors on, and the expecte

Two standard-cell based memories (SCMs) for op- eration in the subthreshold (sub-VT) region are presented. The SCMs accomplish the task of robust sub-VT storage and fill the gap of missing sub-VT memory compilers. The storage elements (latches) of these SCMs are custom-designed cells using a dual- VT approach to balance timing. Additionally, two read-logic styles are presented: 1) a segmented 3-st

Large-scale and population-wide monitoring of waders on their boreal and arctic breeding grounds has hitherto been lacking, mainly because logistics are truly challenging in regions with few ornithologists, vast areas and few roads. In Norway, Sweden and Finland (here 'Fennoscandia') there are now national monitoring schemes in place, aimed at tracking all bird species, which allows trends to be e

Background: Plasmodium falciparum transmission has decreased significantly in Zambia in the last decade. The malaria transmission is influenced by environmental variables. Incorporation of environmental variables in models of malaria transmission likely improves model fit and predicts probable trends in malaria disease. This work is based on the hypothesis that remotely-sensed environmental factor

The study investigates how the early nineteenth century invention of comparative-historical linguistics affected European ethnohistoric thought, and how this process altered ethnohistorical research on the early, pre-Christian history of the Nordic region. The case study of the Nordic region (Denmark, Iceland, Norway, Sweden, Finland and Estonia) includes the discipline histories of Finno-Ugric st

Understanding factors that limit gene flow through the landscape is crucial for conservation of organisms living in fragmented habitats. We analysed patterns of gene flow in Elater ferrugineus, an endangered click beetle living in old-growth, hollow trees in a network of rural avenues surrounded by inhospitable arable land. Using amplified fragment length polymorphism (AFLP) data, we aimed to eval

The influence of peptide hydrophobicity on the interaction between antimicrobial peptides and poly(acrylic, acid) microgels wits studied by end-tagging the kininogen-derived antimicrobial peptide GKHKNKGKKNGKHNGWK (GKH17) and its truncated variant KNKGKKNGKH (KNK10) with oligotryptophan groups of different lengths. Microgel deswelling and reswelling in response to peptide binding and release was s

A peripheral nerve injury may lead to serious disability and influence the individual´s quality of life. It is considered that children can regain better sensory and motor function after a peripheral nerve injury, but the exact mechanism behind such superior recovery is not known. The aim of the thesis was to study the long-term clinical outcome after a peripheral nerve injury in patients injured

Recurrence after radical prostatectomy occurs most frequently during the first 5 years after surgery. Later recurrences have, however, been described. This report describes a case with local recurrence 23 years after radical prostatectomy.

This review describes how computational methods have contributed to the held of cobalamin chemistry since the start of the new millennium. Cobalamins are cobalt-dependent cofactors that are used for alkyl transfer and radical initiation by several classes of enzymes. Since the entry of modern electronic-structure calculations, in particular density functional methods, the understanding of the mole

Chlorophyll biosynthesis is initiated by magnesium chelatase, an enzyme composed of three proteins, which catalyzes the insertion of Mg2+ into protoporphyrin IX to produce Mg-protoporphyrin IX. In barley (Hordeum vulgare L.) the three proteins are encoded by Xantha-f, Xantha-g and Xantha-h. Two of the gene products, XanH and XanG, belong to the structurally conserved family of AAA+ proteins (ATPas