Background: Estimating excess mortality and years of life lost (YLL) attributed to coronavirus disease 19 (COVID-19) infection provides a comprehensive picture of the mortality burden on society. We aimed to estimate the impact of the COVID-19 pandemic on age- and sex-specific excess mortality and YLL in Sweden during the first 17 months of the pandemic. Methods: In this population-based observati

The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non-carriers under multiple physiological conditions with state-of-the-art stable isotope techniques. After an overnight fast, carriers had higher plasma β-hydroxyb

Responding to perceived threats is energetically expensive and can require animals to curtail somatic repair, immunity, and even reproduction to balance energy ledgers. In birds and mammals, energetic demands of thermoregulation are often immense, yet whether homeostatic body temperatures are also compromised to aid the stress response is not known. Using data sourced from over 60 years of literat

Advanced Parkinson's disease (PD) is characterized by motor fluctuations including unpredictable oscillations remarkably impairing quality of life. Effective management and development of novel therapies for these response fluctuations largely depend on clinical rating instruments such as the widely-used PD home diary, which are associated with biases and errors. Recent advancements in digital hea

While the role of grandparents has increasingly been explored, the position of being a grandchild is under-researched. Recognising the active role of children in intergenerational care relationships, we analyse narratives of being a grandchild in Sweden in the 1940s–1950s, the 1970s–1980s, and today. Interviews with 63 participants of both genders show how conditions for care-doings change in resp

In this article, Peter Bengtsen, who has written several books on street art, approaches the topic of Street Art, Science and Engagement as an academic. He discusses how he became interested in environmental street art, how his research developed and how and to what extent environmental street art can influence the viewer and bring about positive behavioural change. Unpacking selected internationa

The purpose of this study is to investigate the relationship between Value at Risk (VaR) and bank-specific characteristics within the Vietnamese financial market, a rapidly growing yet risk-exposed sector. The study uses VaR as a measure of market risk and other characteristics of bank as a proxy for banks’ market power, profitability, risk, solvency, efficiency, and ownership. The study utilizes

Based on the International Conference on Information Systems’ (ICIS) 2014 senior scholars’ forum, we share insights on the relationship between evolving university business models and the adoption of electronic pedagogy. In recent years, particularly with the initiation of MOOCs, the potential for delivering high-quality and widely distributed coursework has expanded. However, particular instances

The energy scaling of integrated circuits has reached its limit because the operating voltage of Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFET) based switches has reached its minimum value. MOSFETs are limited by thermionic emission and cannot achieve a subthreshold swing (SS) below 60 mV/decade at room temperature. Tunnel Field-Effect Transistors (TFET), which operate on field modula

The digital platform Airbnb has gained popularity in a number of countries particu- larly in the Maltese islands. Striking a balance in setting a price that is competitive and also renders a good profit can be a challenge. In this thesis a model is de- veloped to predict the price of a listing in the Maltese islands for September 2022 through a machine learning approach whereby five types of model

Abstract: Glomerular filtration rate (GFR) is considered the best overall index of kidney function in health and disease and its use is recommended to evaluate the risk of iodine contrast medium-induced acute kidney injury (CI-AKI) either as a single parameter or as a ratio between the total contrast medium dose (gram iodine) and GFR. GFR may be expressed in absolute terms (mL/min) or adjusted/ind

Over the last thirty years, suggestions for how to develop defence capability have developed rapidly. However, supporting theory and structured concept development lag behind. Despite this imbalance, countries need to continuously spend resources on defence development. This study identifies central challenges in relation to the scientific perspectives and approaches needed to support the developm

The syndicated loan market is a major source of corporate funding, raising $5 trillion in 2021. The secondary market where these loans are traded has seen a rapid growth in the last few decades. This growth was accompanied by the entrance of new types of participants, increasing the investor diversity. Similar to other markets, there is a price difference between the initial stage and the entrance

GERMAN SUMMARY: Gegenstand dieser Arbeit sind die verkürzten Formen (Kontraktionen) der englischen Modalausdrücke (‘semi-modals’) 'BE going to', 'HAVE got to' und 'want to'. Die Kontraktionen sind in der gesprochenen Sprache häufig und zeigen sich in den Schreibweisen 'gonna', 'gotta' und 'wanna'. Sie werden im Nordamerikanischen Englisch untersucht. Den Hintergrund der Arbeit bildet die GrammThe current restructuring of the English modal system has long been noted as an ongoing language change process. Semi-modal constructions such as 'BE going to' and 'HAVE got to' are textbook cases of grammaticalization. As grammaticalization comes with a rise in frequency, these semi-modals are also typical examples of the ‘reducing effect’ of frequency, which leads to the contracted forms 'gonna'

The effect of exposure to toluene on plasma concentrations of testosterone, prolactin, luteinising (LH) and follicle stimulating (FSH) hormones was investigated in 47 rotogravure printers (time weighted average air toluene below 80 ppm; blood toluene concentration post-shift 0.19-7.99 mumol/l) and compared with a reference group. Increasing exposure concentrations of toluene (concentrations less t

Stroke results in local neural disconnection and brain-wide neuronal network dysfunction leading to neurological deficits. Beyond the hyper-acute phase of ischemic stroke, there is no clinically-approved pharmacological treatment that alleviates sensorimotor impairments. Functional recovery after stroke involves the formation of new or alternative neuronal circuits including existing neural connec

People consistently act in ways that harm the environment, even when believing their actions are environmentally friendly. A case in point is a biased judgment termed the negative footprint illusion, which arises when people believe that the addition of “eco-friendly” items (e.g., environmentally certified houses) to conventional items (e.g., standard houses), reduces the total carbon footprint of

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platele