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Cubosomes for in vivo fluorescence lifetime imaging

Herein we provided the first proof of principle for in vivo fluorescence optical imaging application using monoolein-based cubosomes in a healthy mouse animal model. This formulation, administered at a non-cytotoxic concentration, was capable of providing both exogenous contrast for NIR fluorescence imaging with very high efficiency and chemospecific information upon lifetime analysis. Time-resolv

Peak-to-valley ratios for three different HPGe detectors for the assessment of 137Cs deposition on the ground and the impact of the detector field-of-view

The peak-to-valley (PTV) method was investigated experimentally comparing PTV ratios for three HPGe detectors, with complementary Monte Carlo simulations of scatter in air for larger source-detector distances. The measured PTV ratios for 137Cs in air were similar for three different detectors for incident angles between 0 and 90°. The study indicated that the PTV method can differentiate between s

Regulatory Trust in EU Free Movement Law: Adopting the Level of Protection of the Other?

The principles of mutual trust and mutual recognition are well established features of EU law. On a technical level, it is clear that the principles may require adoption of foreign levels of protection in individual cases as well as in legislation. At a closer look, however, the principles through “the rule of reason” also may imply quite the opposite: the imposing of domestic requirements on fore

Multidimensional diffusion MRI

Principles from multidimensional NMR spectroscopy, and in particular solid-state NMR, have recently been transferred to the field of diffusion MRI, offering non-invasive characterization of heterogeneous anisotropic materials, such as the human brain, at an unprecedented level of detail. Here we revisit the basic physics of solid-state NMR and diffusion MRI to pinpoint the origin of the somewhat u

Evidence against observational spatial memory for cache locations of conspecifics in marsh tits Poecile palustris

Abstract: Many species in the family Paridae, such as marsh tits Poecile palustris, are large-scale scatter hoarders of food that make cryptic caches and disperse these in large year-round territories. The perhaps most well-known species in the family, the great tit Parus major, does not store food itself but is skilled in stealing caches from the other species. We have previously demonstrated tha

Response of moist paperboard during rapid compression and heating

The response of moist paperboard exposed to extensive compression and heating in short periods of time is investigated. A generic framework describing this response, in a thermodynamically consistent manner, has been derived previously. The present paper provides explicit formats of the necessary constitutive relations specific to moist paperboard exposed to extensive compression and heating in sh

Wåhlins värld : Ett porträtt i ord och bild av domkyrkoarkitekt Theodor Wåhlin

En fotobok om en av Lunds, Malmös och faktiskt hela Skånes mest betydelsefulla men numera bortglömda arkitekter; Theodor Wåhlin (1864–1948). Med 80 utvalda fotografier, tagna av Wåhlin själv mellan 1880- och 1930-talet, ger boken för första gången en både estetisk och biografisk helhetsbild av såväl hans yrkes som privatliv.

Design of a potentially prebiotic and responsive encapsulation material for probiotic bacteria based on chitosan and sulfated β-glucan

Hypothesis Chitosan and sulfated oat β-glucan are materials suitable to create a prebiotic coating for targeted delivery to gastrointestinal system, using the layer by layer technology. Experiment Quartz crystal microbalance with dissipation (QCM-D), spectroscopic ellipsometry (SE) and atomic force microscopy (AFM) were used to assess the multilayer formation capacity and characterize the resultin

Diverging temporal trends of human exposure to bisphenols and plastizisers, such as phthalates, caused by substitution of legacy EDCs?

Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased huma

Concrete alteration due to 55 years of exposure to river water : Chemical and mineralogical characterisation

This article presents a study on concrete alteration mechanisms due to 55 years of exposure to river water. Many hydro power structures in cold regions suffer from concrete deterioration at the waterline. Progressive disintegration of the concrete surface leads to exposure of the coarse aggregate and eventually the reinforcing steel. Concrete cylinders drilled out at four vertically different loca

Pediatric T-cell acute lymphoblastic leukemia

The most common pediatric malignancy is acute lymphoblastic leukemia (ALL), of which T-cell ALL (T-ALL) comprises 10–15% of cases. T-ALL arises in the thymus from an immature thymocyte as a consequence of a stepwise accumulation of genetic and epigenetic aberrations. Crucial biological processes, such as differentiation, self-renewal capacity, proliferation, and apoptosis, are targeted and derange

Causal analysis for alarm flood reduction

The introduction of distributed control systems and the high level of interconnectivity of modern process plants has caused alarm flooding to become one of the main problems in alarm management of process plants. A reduction of alarm flood periods contributes to a decrease in plant incidents. In this work, a combination of alarm log, process data and connectivity analysis is used to isolate conseq

Hysteretic Dynamics of Flashback in a Low-Swirl Stabilized Combustor

The hysteretic behavior of flashback (FB) and flash forward (FF) in methane and natural gas flames, stabilized by a low swirl fuel injector, is investigated using high speed OH* chemiluminescence and particle image velocimetry. Due to the lack of vortex breakdown, the two mechanisms discussed are boundary layer and turbulence induced FB. Two hysteresis cycles were identified, one when FB is induce

The contribution of successional grasslands to the conservation of semi-natural grasslands species – A landscape perspective

Many species that are typical of calcareous, semi-natural grasslands (“typical grassland species”) are declining in Europe as a result of habitat-loss and -fragmentation. Whereas populations of these species are expected to be largest in old semi-natural grasslands, these species may also occur in successional grasslands on previously arable fields. We used a space-for-time approach to analyse cha