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Improving risk assessment in the European Food Safety Authority: lessons from the European Medicines Agency

The recent Regulation (EU) 2019/1381, published on the 6th September 2019, aims to improve the transparency and sustainability of the EU risk assessment in the food chain by amending the General Food Law Regulation (EC 178/2002) and a number of other regulations related to the food sector. This Regulation is introduced as a response to the Fitness Check of the General Food Law Regulation as well a

Quantification and detection of genetic risk factors in the familial aggregation of cancer : Habilitation thesis

SummaryCancer is a multifactorial inheritance disorder caused by a combination of small variations in genes, often acting together with environmental factors. GWASs provide a potential method to investigate the genetic basis of such complex diseases, but they are limited to two main classes of cancer susceptibility variants with different levels of risk and prevalence in the general population: ra

Incentives in Education and Moral Behavior in Groups

This thesis uses field experiments, lab experiments, and theory to study questions that are relevant to the fields of education and behavioral economics.The first paper, Threshold Incentives and Academic Performance, begins with the observation that students often face incentives to reach performance thresholds. To study how these incentives affect their performance, Erik Wengström and I conduct a

Optimal Trade-Off Between Economic Activity and Health During an Epidemic

Thispaperconsidersasimplemodelwhereasocialplannercaninfluencethespread-intensity of an infection wave, and, consequently, also the economic activity and population health, throughasingleparameter. Populationhealthisassumedtoonlybenegativelyaffectedwhen thenumberofsimultaneouslyinfectedexceedshealthcarecapacity. Themainfindingisthat if (i) the planner attaches a positive weight on economic activity a

Organizing Time Exchanges: Lessons from Matching Markets

This paper considers time exchanges via a common platform (e.g., markets for exchanging time units, positions at education institutions, and tuition waivers). There are several problems associated with such markets, e.g., imbalanced outcomes, coordination problems, and inefficiencies. We model time exchanges as matching markets and construct a non-manipulable mechanism that selects an individually

Cooking and electronic cigarettes leading to large differences between indoor and outdoor particle composition and concentration measured by aerosol mass spectrometry

We spend about two thirds of our time in private homes where airborne particles of indoor and outdoor origins are present. The negative health effects of exposure to outdoor particles are known. The characteristics of indoor airborne particles, though, are not well understood. This study assesses the differences in chemical composition of PM1 (

Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation

Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global act

Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization

Immunoglobulin A (IgA) is the dominant antibody isotype in the gut and has been shown to regulate microbiota. Mucosal IgA is also widely believed to prevent food allergens from penetrating the gut lining. Even though recent work has elucidated how bacteria-reactive IgA is induced, little is known about how IgA to food antigens is regulated. Although IgA is presumed to be induced in a healthy gut a

αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of

Odlade alger – ett framtidshopp?

Algodling är globalt en stor industri, men produktionen i Europa är liten. Algodling kan bidra till ekonomisk tillväxt genom produktion av biomassa och samtidigt tillhandahålla miljönyttor som exempelvis upptag av kväve och fosfor ur havet. Ett hinder för utvecklingen av algodling kan vara låg vinstpotential i industrin. Därför undersöker vi lönsamheten i algodling på den svenska västkusten. Vi fi

What is diatomite?

Different types of biogenic remains, ranging from siliceous algae to carbonate precipitates, accumulate in the sediments of lakes and other aquatic ecosystems. Unicellular algae called diatoms, which form a siliceous test or frustule, are an ecologically and biogeochemically important group of organisms in aquatic environments and are often preserved in lake or marine sediments. When diatoms accum

Hydrological changes in Yellowstone Lake (USA) during the Holocene based on the analysis of oxygen isotopes in diatoms

Northern Yellowstone Lake is on the southeast edge of the 631-ka Yellowstone caldera and is an area with high heat flow, high seismicity, and an abundance of active hydrothermal features and structures. Several large hydrothermal explosions since the last glacial recession formed craters of more than 100 m in diameter. These large craters raise the question on how climate and hydrological changes

Mitochondrial dysfunction and calcium dysregulation in leigh syndrome induced pluripotent stem cell derived neurons

Leigh syndrome (LS) is the most frequent infantile mitochondrial disorder (MD) and is characterized by neurodegeneration and astrogliosis in the basal ganglia or the brain stem. At present, there is no cure or treatment for this disease, partly due to scarcity of LS models. Current models generally fail to recapitulate important traits of the disease. Therefore, there is an urgent need to develop

Impact of Storage Time on Characteristics of Synthetic Greywater for Two Different Pollutant Strengths to Be Treated or Recycled

Storage of greywater is controversial for environmental and health reasons. Artificial greywater was assessed after 2 and 7 days of storage time. Two different greywater pollutant strengths were statistically compared at each storage time. A negative significant (p < 0.05) correlation was evident with increasing storage time for the 5-day biochemical oxygen demand for more than 2 days. However, th

Extracorporeal photopheresis for graft-vs-host disease : A literature review and treatment guidelines proposed by the Nordic ECP Quality Group

Extracorporeal photopheresis (ECP) is one of the most used and established therapies for steroid-refractory graft-vs-host disease (GvHD), with a good effect to side effect profile. In this review, we present a summary of present literature and provide evidence-based treatment guidelines for ECP in GvHD. The guidelines constitute a consensus statement formed by the Nordic ECP Quality Group represen

Happiness and Gold Prices

We use the Twitter-based Hedonometer happiness index to study the link between happiness and gold price changes. We find no significant correlation between the two when we look at correlations across the entire distributions. However, turning to an extreme value theory (EVT) modeling of the tails of the non-normally distributed happiness distribution we find that during particularly depressing day