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Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+

The block of rabbit skeletal ryanodine receptors (RyR1) and dog heart RyR2 by cytosolic [Mg2+], and its reversal by agonists Ca2+, ATP and caffeine was studied in planar bilayers. Mg2+ effects were tested at submaximal activating [Ca2+] (5 microM). Approximately one third of the RyR1s had low open probability ("LA channels") in the absence of Mg2+. All other RyR1s displayed higher activity ("HA ch

The next generation of hemophilia treatment specialists

We currently are witnessing a serious attrition of physicians specializing in hemophilia treatment in Europe and the United States while most physicians who complete training in hematology-oncology choose oncology practice as their career. Nevertheless, recent therapeutic developments, including advances in prophylaxis and inhibitor management, have renewed the demand for experts in hemophilia and

The influence of external precipitating factors and peripheral neuropathy on the development and outcome of diabetic foot ulcers

The influence of external precipitating factors and the presence of peripheral neuropathy on the development and outcome of foot ulcers were evaluated in 314 consecutive diabetic patients. All patients were treated by the same foot care team. Each patient was represented by one ulcer, and primary healing was defined as intact skin for at least six months. External precipitating factors were identi

A puzzling periodicity in the pulsating DA white dwarf G 117-B15A

We present time-resolved optical spectrophotometry of the pulsatinghydrogen atmosphere (DA) white dwarf G 117-B15A. We find threeperiodicities in the pulsation spectrum (215 s, 272 s, and 304 s) all ofwhich have been found in earlier studies. By comparing the fractionalwavelength dependence of the pulsation amplitudes (chromatic amplitudes)with models, we confirm a previous report that the stronge

Med samarbete i sikte : Om samordnade insatser och samlokaliserade familjecentraler

Popular Abstract in Swedish Samarbete är ett värdeladdat ord i svenskt välfärdsarbete och inom socialt arbete förespråkas samarbete ofta som något värdefullt och nödvändigt. Idag finns det en stor, om än fragmenterad, vardagskunskap om samarbete och samverkan. Vetandet präglas dock av ett okritiskt accepterande av samarbetets fördelar, samtidigt som många verksamheter visar att resultaten av samarCo-operation is highly valued in Swedish welfare work and joint efforts within and between healthcare and welfare organizations is not new in Sweden. For decades the authorities have been trying to organize and coordinate various social and medical efforts in the public sector at a central level. This thesis is focusing on the meaning of co-operation between professionals belonging to different or

Uptake of Sr-87 from microcline and biotite by ectomycorrhizal fungi in a Norway spruce forest

Ectomycorrhizal (EM) fungi growing in symbiosis with tree seedlings have been found in laboratory experiments to stimulate weathering and the uptake of nutrients from silicate minerals. In the present study, we used the natural abundance of strontium isotopes to confirm that these fungi obtain strontium from biotite and microcline under field conditions. Minerals enriched in radiogenic Sr-87 were

Second-generation hepatitis C Elisa antibody tests confirmed by the four-antigen recombinant immunoblot assay correlate well with hepatitis C viremia and chronic liver disease in Swedish blood donors

Seventy-three Swedish blood donors (52 men, 21 women; median age 36 years) repeatedly reactive for hepatitis C antibodies (anti-HCV C-100-3) were tested with a second-generation (2nd-gen) anti-HCV Elisa and a 4-band recombinant immunoblot assay (RIBA 2). These results were correlated to serum alanine aminotransferase (S-ALAT), liver morphology and viremia as detected by 'nested' polymerase chain r

Complex analytical approach to characterization of the influence of carbon dioxide concentration on carbohydrate composition in Norway spruce needles

Water-soluble non-structural carbohydrates (NSC) in the needles of Norway spruce Picea abies [L.] Karst have been studied by using a combination of several separation techniques, having various detectors, with mass spectrometry. The intent was to find a suitable methodology that enables the characterization and determination of NSC, covering a wide range of molar masses, and being suitable to asse

Combustion Engine Models for Hybrid Vehicle System Development

This report is part of a project that is called Generic hybrid systems. Its objective is to simulate and investigate electric hybrid drive trains. The goal of this work has been to develop combustion engine models that are computer efficient, but still has the potential of giving both qualitative and quantitative results. For instance, if the model is run in a less ideal manner the model will show

Shell Age Economics : Marine Gathering in the Kingdom of Tonga, Polynesia

Popular Abstract in Swedish Denna studie är inriktad på förhållandet mellan människa och hav på Tongaöarna i Polynesien. Särskild tonvikt läggs på det samlande av alger och ryggradslösa djur som utförs av kvinnorna i lagunerna och på korallreven. Beskrivningar ges av hur dessa organismer anskaffas och hur de används för olika ändamål, den plats de haft i religiösa föreställningar samt hur folkökniThis monograph analyses marine gathering in the Polynesian Kingdom of Tonga from ecological, social and cognitive perspectives. The overarching issues explored are (1) the significance of marine gathering in the past and present, (2) how seaweeds and marine invertebrates have been perceived, classified, named and used, (3) how they have been implicated in social relations, and (4) how the integrat

Condition-Based Maintenance: Selection and Improvement of a Cost-Effective Vibration-Based Maintenance Policy for Rolling element Bearings

Popular Abstract in Swedish Moderna tillverkningsmaskiner är dyra och därför måste dess tillgänglighet och effektivitet ständigt hållas högt. Sådana resultat kan man inte åstadkomma utan tillämpning av en effektiv underhållsstrategi. Förutsättningar för att minska eller arrestera förslitnings hastighet på maskins delar och öka maskinlivslängden är stora vid användning av tillståndsövervakning, (TÖModern machinery is expensive and therefore must run at high availability and effectiveness which cannot be achieved without an effective maintenance policy. Condition monitoring, (CM), techniques can be utilised to reduce or arrest the rate of deterioration of a component so increasing operating life. The main result reported in this thesis is that the rolling element bearing’s mean effective li

Reactors - Circuit Theory and Silicon Integrated Applications

This dissertation deals with reactive components in electric circuits, both as targets for a theoretical circuit analysis, and as devices implemented in silicon processes like CMOS. The frequency behavior of a general electric network is determined by the reactances (i.e., inductances and capacitances) present in the network, either as intentional parts of the design, or as process and implementa